Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer’s Disease Mouse Model

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Lactoferrin, a Pleiotropic Protein in Health and Disease

(2016) Sylvain Mayeur et al.   ANTIOXIDANTS & REDOX SIGNALING

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

(2016) Chuang Guo et al.   EXPERIMENTAL NEUROLOGY

RACK1 promotes maintenance of morphine-associated memory via activation of an ERK-CREB dependent pathway in hippocampus

(2016) Litao Liu et al.   Scientific Reports

Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes

(2015) Keiko Ikoma-Seki et al.   PLoS One

The protective effect of lactoferrin on ventral mesencephalon neurons against MPP+ is not connected with its iron binding ability

(2015) Jun Wang et al.   Scientific Reports

Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17

(2014) Mayuri Shukla et al.   JOURNAL OF PINEAL RESEARCH

Lactoferrin during lactation protects the immature hypoxic-ischemic rat brain

(2014) Yohan van de Looij et al.   Annals of Clinical and Translational Neurology

Protective Effects of Human Lactoferrin during Aggregatibacter actinomycetemcomitans-Induced Bacteremia in Lactoferrin-Deficient Mice

(2013) S. K. Velusamy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes

(2013) Dongyao Yan et al.   GENE

Enhanced Brain Delivery of Deferasirox–Lactoferrin Conjugates for Iron Chelation Therapy in Neurodegenerative Disorders: In Vitro and in Vivo Studies

(2013) Golnaz Kamalinia et al.   MOLECULAR PHARMACEUTICS

CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat

(2013) Irina N. Krasnova et al.   NEUROBIOLOGY OF DISEASE

Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha

(2012) Elena T. Zakharova et al.   BIOMETALS

CREB-Dependent Transcriptional Control and Quantal Changes in Persistent Long-Term Potentiation in Hippocampal Interneurons

(2012) I. Ran et al.   JOURNAL OF NEUROSCIENCE

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

(2012) X.-Z. Wan et al.   JOURNAL OF NEUROSCIENCE

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex

(2012) Guofen Cao et al.   NEUROPHARMACOLOGY

Lactoferrin a multiple bioactive protein: An overview

(2011) Isui Abril García-Montoya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide

(2011) I. B. Barsoum et al.   CANCER RESEARCH

Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in caco-2 cells

(2011) Rulan Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Iron metabolism and the innate immune response to infection

(2011) Erin E. Johnson et al.   MICROBES AND INFECTION

The Role of Iron and Chelators on Infections in Iron Overload and Non Iron Loaded Conditions: Prospects for the Design of New Antimicrobial Therapies

(2010) George J. Kontoghiorghes et al.   HEMOGLOBIN

Activity-dependent α-Cleavage of Nectin-1 Is Mediated by A Disintegrin and Metalloprotease 10 (ADAM10)

(2010) Jinsook Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural products as a source of Alzheimer's drug leads

(2010) Philip Williams et al.   NATURAL PRODUCT REPORTS

Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease

(2010) Ligang Wang et al.   NEUROSCIENCE LETTERS

Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model

(2009) Marian L. Kruzel et al.   Innate Immunity

Activated astroglia during chronic inflammation in Alzheimer's disease—Do they neglect their neurosupportive roles?

(2009) Stacey Fuller et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation

(2008) Yoshifumi Iwamaru et al.   JOURNAL OF NEUROCHEMISTRY

Neuroscience: The plaque plan

(2008) Alison Abbott   NATURE