Distinct Lipid A Moieties Contribute to Pathogen-Induced Site-Specific Vascular Inflammation

TLR/MyD88 and Liver X Receptor   Signaling Pathways Reciprocally Control Chlamydia pneumoniae-Induced Acceleration of Atherosclerosis

(2014) Y. Naiki et al.   JOURNAL OF IMMUNOLOGY

Bacterial Fimbriae Stimulate Proinflammatory Activation in the Endothelium through Distinct TLRs

(2014) M. Davey et al.   JOURNAL OF IMMUNOLOGY

Porphyromonas gingivalis Lipid A Phosphatase Activity Is Critical for Colonization and Increasing the Commensal Load in the Rabbit Ligature Model

(2013) Camille Zenobia et al.   INFECTION AND IMMUNITY

A Novel Class of Lipoprotein Lipase-Sensitive Molecules Mediates Toll-Like Receptor 2 Activation by Porphyromonas gingivalis

(2013) Sumita Jain et al.   INFECTION AND IMMUNITY

Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis

(2013) Brittany D. Needham et al.   NATURE REVIEWS MICROBIOLOGY

Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts

(2013) Thanuja D. K. Herath et al.   PLoS One

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms

(2013) Petr Broz et al.   PLoS Pathogens

Recognition of lipid A variants by the TLR4-MD-2 receptor complex

(2013) Nina Maeshima et al.   Frontiers in Cellular and Infection Microbiology

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

(2012) Dominique S Michaud et al.   GUT

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Porphyromonas gingivalisMediates Inflammasome Repression in Polymicrobial Cultures through a Novel Mechanism Involving Reduced Endocytosis

(2012) Debra J. Taxman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Role for TLR4 Signaling in Atherosclerosis Progression as Revealed by Infection with a Common Oral Pathogen

(2012) C. Hayashi et al.   JOURNAL OF IMMUNOLOGY

Macrophage-Specific TLR2 Signaling Mediates Pathogen-Induced TNF-Dependent Inflammatory Oral Bone Loss

(2012) G. Papadopoulos et al.   JOURNAL OF IMMUNOLOGY

Microbial Carriage State of Peripheral Blood Dendritic Cells (DCs) in Chronic Periodontitis Influences DC Differentiation, Atherogenic Potential

(2012) J. Carrion et al.   JOURNAL OF IMMUNOLOGY

LPS remodeling is an evolved survival strategy for bacteria

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen-Mediated Proteolysis of the Cell Death Regulator RIPK1 and the Host Defense Modulator RIPK2 in Human Aortic Endothelial Cells

(2012) Andrés G. Madrigal et al.   PLoS Pathogens

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

(2011) George Hajishengallis et al.   Cell Host & Microbe

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Free Lipid A Isolated from Porphyromonas gingivalis Lipopolysaccharide Is Contaminated with Phosphorylated Dihydroceramide Lipids: Recovery in Diseased Dental Samples

(2011) Frank C. Nichols et al.   INFECTION AND IMMUNITY

Temperature-Dependent Modulation ofPorphyromonas gingivalisLipid A Structure and Interaction with the Innate Host Defenses

(2011) Michael A. Curtis et al.   INFECTION AND IMMUNITY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Pathogens and atherosclerosis: Update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis

(2011) Lee Ann Campbell et al.   THROMBOSIS AND HAEMOSTASIS

Helicobacter pylori versus the Host: Remodeling of the Bacterial Outer Membrane Is Required for Survival in the Gastric Mucosa

(2011) Thomas W. Cullen et al.   PLoS Pathogens

Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice

(2010) Chie Hayashi et al.   ATHEROSCLEROSIS

Inflammasome Inhibition as a Pathogenic Stealth Mechanism

(2010) Debra J. Taxman et al.   Cell Host & Microbe

The Lipid A Phosphate Position Determines Differential Host Toll-Like Receptor 4 Responses to Phylogenetically Related Symbiotic and Pathogenic Bacteria

(2010) Stephen R. Coats et al.   INFECTION AND IMMUNITY

High Antibody Levels to P. gingivalis in Cardiovascular Disease

(2010) S. Bohnstedt et al.   JOURNAL OF DENTAL RESEARCH

Pathogen-Mediated Inflammatory Atherosclerosis Is Mediated in Part via Toll-Like Receptor 2-Induced Inflammatory Responses

(2010) Chie Hayashi et al.   Journal of Innate Immunity

REVIEW: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways

(2010) C. Hayashi et al.   Molecular Oral Microbiology

Porphyromonas gingivalis Resistance to Polymyxin B Is Determined by the Lipid A 4′‐Phosphatase, PGN_0524

(2010) Stephen R Coats et al.   International Journal of Oral Science

Human Toll-like receptor 4 responses toP. gingivalisare regulated by lipid A 1- and 4′-phosphatase activities

(2009) Stephen R. Coats et al.   CELLULAR MICROBIOLOGY

Periodontitis and risk for atherosclerosis: an update on intervention trials

(2009) Maurizio S. Tonetti   JOURNAL OF CLINICAL PERIODONTOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Pseudomonas aeruginosa Exploits Lipid A and Muropeptides Modification as a Strategy to Lower Innate Immunity during Cystic Fibrosis Lung Infection

(2009) Cristina Cigana et al.   PLoS One

Identification of a Second Lipopolysaccharide in Porphyromonas gingivalis W50

(2008) M. Rangarajan et al.   JOURNAL OF BACTERIOLOGY

Discovery and Development of Toll-Like Receptor 4 (TLR4) Antagonists: A New Paradigm for Treating Sepsis and Other Diseases

(2008) Carlos G. Leon et al.   PHARMACEUTICAL RESEARCH