Low levels of salivary lactoferrin may affect oral dysbiosis and contribute to Alzheimer’s disease: A hypothesis

Is Alzheimer’s disease a polymicrobial host microbiome dysbiosis?

(2020) Sim K. Singhrao et al.   Expert Review of Anti-Infective Therapy

Dietary Lactoferrin Supplementation Prevents Memory Impairment and Reduces Amyloid-β Generation in J20 Mice

(2020) Mona Abdelhamid et al.   JOURNAL OF ALZHEIMERS DISEASE

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria

(2020) Douglas B. Kell et al.   Frontiers in Immunology

Salivary lactoferrin as biomarker for Alzheimer's disease: Brain‐immunity interactions

(2020) Félix Bermejo‐Pareja et al.   Alzheimers & Dementia

Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics

(2020) J. Massimo Nunes et al.   Frontiers in Immunology

Decreased salivary lactoferrin levels are specific to Alzheimer's disease

(2020) Marta González-Sánchez et al.   EBioMedicine

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer’s disease

(2019) Sim K. Singhrao et al.   Journal of Oral Microbiology

The role of natural salivary defences in maintaining a healthy oral microbiota

(2019) Anne Marie Lynge Pedersen et al.   JOURNAL OF DENTISTRY

A pilot study on the effect of lactoferrin on Alzheimer’s disease pathological sequelae: Impact of the p-Akt/PTEN pathway

(2019) Waleed A. Mohamed et al.   BIOMEDICINE & PHARMACOTHERAPY

Lactoferrin in Aseptic and Septic Inflammation

(2019) Maria Stefania Lepanto et al.   MOLECULES

Effect of tablets containing lactoferrin and lactoperoxidase on gingival health in adults: A randomized, double‐blind, placebo‐controlled clinical trial

(2019) Manabu Nakano et al.   JOURNAL OF PERIODONTAL RESEARCH

Salivary biomarkers for the diagnosis and monitoring of neurological diseases

(2018) Raymond Farah et al.   Biomedical Journal

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

(2018) Vladimir Ilievski et al.   PLoS One

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

(2018) Jun-Lin Liu et al.   Frontiers in Neuroscience

Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer’s Type Dementia

(2018) Lesha Pretorius et al.   Frontiers in Neuroscience

Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

(2017) Chang-Kai Chen et al.   Alzheimers Research & Therapy

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease

(2016) Etheresia Pretorius et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

(2016) Nian-Sheng Tzeng et al.   NEUROEPIDEMIOLOGY

Levels of the antimicrobial proteins lactoferrin and chromogranin in the saliva of individuals with oral dryness

(2015) Fumi Mizuhashi et al.   JOURNAL OF PROSTHETIC DENTISTRY

Polymicrobial synergy and dysbiosis in inflammatory disease

(2015) Richard J. Lamont et al.   TRENDS IN MOLECULAR MEDICINE

Can oral infection be a risk factor for Alzheimer's disease?

(2015) Ingar Olsen et al.   Journal of Oral Microbiology

The Role of Iron-Induced Fibrin in the Pathogenesis of Alzheimer’s Disease and the Protective Role of Magnesium

(2013) Boguslaw Lipinski et al.   Frontiers in Human Neuroscience

Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease

(2012) Pamela Sparks Stein et al.   Alzheimers & Dementia

Lactoferrin Inhibits Porphyromonas gingivalis Proteinases and Has Sustained Biofilm Inhibitory Activity

(2012) Stuart G. Dashper et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Porphyromonas gingivalis as a Potential Community Activist for Disease

(2012) R.P. Darveau et al.   JOURNAL OF DENTAL RESEARCH

Elevated levels of salivary lactoferrin, a marker for chronic periodontitis?

(2012) P. Glimvall et al.   JOURNAL OF PERIODONTAL RESEARCH

The keystone-pathogen hypothesis

(2012) George Hajishengallis et al.   NATURE REVIEWS MICROBIOLOGY

Periodontal health status and bacteraemia from daily oral activities: systematic review/meta-analysis

(2011) Inmaculada Tomás et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Periodontitis, periodontopathic bacteria and lactoferrin

(2010) Hiroyuki Wakabayashi et al.   BIOMETALS

Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease

(2010) Ligang Wang et al.   NEUROSCIENCE LETTERS

Inhibitory Effects of Lactoferrin on Growth and Biofilm Formation of Porphyromonas gingivalis and Prevotella intermedia

(2009) H. Wakabayashi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diverse and Novel Oral Bacterial Species in Blood following Dental Procedures

(2008) F. K. Bahrani-Mougeot et al.   JOURNAL OF CLINICAL MICROBIOLOGY