Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases: Possible Impact of Environmental Exposures

Copper in Alzheimer's Disease: A Meta-Analysis of Serum, Plasma, and Cerebrospinal Fluid Studies

(2018) Serena Bucossi et al.   JOURNAL OF ALZHEIMERS DISEASE

High Blood Caffeine Levels in MCI Linked to Lack of Progression to Dementia

(2018) Chuanhai Cao et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Exposure and the Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studiess

(2017) João Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

(2012) Lana Kupershmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Luteolin Reduces Zinc-Induced Tau Phosphorylation at Ser262/356 in an ROS-Dependent Manner in SH-SY5Y Cells

(2012) Futao Zhou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention

(2012) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

(2012) Henryk Kozlowski et al.   COORDINATION CHEMISTRY REVIEWS

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Pharmacoeconomic considerations of treating patients with advanced Parkinson's disease

(2012) Jens P Reese et al.   EXPERT OPINION ON PHARMACOTHERAPY

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Design and Synthesis of Fluorinated Iron Chelators for Metabolic Study and Brain Uptake

(2012) Yongmin Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats

(2012) Yan Zhou et al.   JOURNAL OF NEUROCHEMISTRY

The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked by Prominent RNA Oxidation in Vulnerable Neurons

(2012) Akihiko Nunomura et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Sting of Alzheimer's failures offset by upcoming prevention trials

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

(2012) Desiree Antequera et al.   NEUROBIOLOGY OF DISEASE

IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP+-Induced Neurodegeneration

(2012) Björn Spittau et al.   NEUROMOLECULAR MEDICINE

Brief mitochondrial inhibition causes lasting changes in motor behavior and corticostriatal synaptic physiology in the Fischer 344 rat

(2012) G. Akopian et al.   NEUROSCIENCE

The similar neurotoxic effects of nanoparticulate and ionic silver in vivo and in vitro

(2012) Niels Hadrup et al.   NEUROTOXICOLOGY

Preventing Alzheimer's Disease

(2012) D. J. Selkoe   SCIENCE

Hepcidin and the Iron-Infection Axis

(2012) H. Drakesmith et al.   SCIENCE

A Proteomic Analysis of MCLR-induced Neurotoxicity: Implications for Alzheimer's Disease

(2012) Guangyu Li et al.   TOXICOLOGICAL SCIENCES

The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats

(2012) Ye Liu et al.   TOXICOLOGY LETTERS

High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats

(2012) Chao Sun et al.   TOXICOLOGY LETTERS

Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro

(2012) Yang Xue et al.   TOXICOLOGY LETTERS

Wine, Beer, Alcohol and Polyphenols on Cardiovascular Disease and Cancer

(2012) Sara Arranz et al.   Nutrients

Hepcidin Treatment Modulates the Expression of Divalent Metal Transporter-1, Ceruloplasmin, and Ferroportin-1 in the Rat Cerebral Cortex and Hippocampus

(2011) Lin Li et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits

(2011) Andrew Sauerbeck et al.   EXPERIMENTAL NEUROLOGY

The promise of anti-inflammatory therapies for CNS injuries and diseases

(2011) Serge Rivest   Expert Review of Neurotherapeutics

Air pollution is associated with brainstem auditory nuclei pathology and delayed brainstem auditory evoked potentials

(2011) Lilian Calderón-Garcidueñas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Patterns of levels of biological metals in CSF differ among neurodegenerative diseases

(2011) Isao Hozumi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

CSF α-synuclein, tau, and amyloid β in Parkinson's disease

(2011) Min Shi et al.   LANCET NEUROLOGY

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

The potential application of iron chelators for the treatment of neurodegenerative diseases

(2011) Robert C. Hider et al.   Metallomics

Interferon-γ plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways

(2011) Emily N. Mangano et al.   NEUROBIOLOGY OF AGING

Carotenoids and Alzheimer’s Disease: An insight into therapeutic role of retinoids in animal models

(2011) M. Obulesu et al.   NEUROCHEMISTRY INTERNATIONAL

Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging

(2011) George Bartzokis et al.   NEUROPSYCHOPHARMACOLOGY

Neurological impacts from inhalation of pollutants and the nose–brain connection

(2011) R.G. Lucchini et al.   NEUROTOXICOLOGY

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Microcystin Congener– and Concentration-Dependent Induction of Murine Neuron Apoptosis and Neurite Degeneration

(2011) Daniel Feurstein et al.   TOXICOLOGICAL SCIENCES

Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells

(2011) Nana Asare et al.   TOXICOLOGY

The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells

(2011) Anna Lankoff et al.   TOXICOLOGY LETTERS

Reactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain

(2010) Joshua W. Little et al.   AMINO ACIDS

Antimicrobial Peptides in the Brain

(2010) Yanhua Su et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

(2010) Heidi A. Jurgens et al.   EXPERIMENTAL NEUROLOGY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Zinc prevents the copper-induced damage of cultured astrocytes

(2010) Ivo F. Scheiber et al.   NEUROCHEMISTRY INTERNATIONAL

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

Environmental toxins and Parkinson’s disease: Putative roles of impaired electron transport chain and oxidative stress

(2010) Ibrahim Abdulwahid Arif et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease

(2009) J. Pablo et al.   ACTA NEUROLOGICA SCANDINAVICA

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

(2009) Akihiko Nunomura et al.   ACTA NEUROPATHOLOGICA

Parkinson's Disease and Residential Exposure to Maneb and Paraquat From Agricultural Applications in the Central Valley of California

(2009) S. Costello et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Role of Neuroimmunomodulation in Alzheimer's Disease

(2009) Ricardo B. Maccioni et al.   Annals of the New York Academy of Sciences

Role of hepcidin in murine brain iron metabolism

(2009) S.-M. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Urban air pollution: Influences on olfactory function and pathology in exposed children and young adults

(2009) Lilian Calderón-Garcidueñas et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice

(2009) Mark A. Lovell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

IL-13-Induced Oxidative Stress via Microglial NADPH Oxidase Contributes to Death of Hippocampal Neurons In Vivo

(2009) K. W. Park et al.   JOURNAL OF IMMUNOLOGY

Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice

(2009) Randy L. Hunter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Getting the iron out: Phlebotomy for Alzheimer’s disease?

(2009) Barney E. Dwyer et al.   MEDICAL HYPOTHESES

Synergistic microglial reactive oxygen species generation induced by pesticides lindane and dieldrin

(2009) Haoyu Mao et al.   NEUROREPORT

Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation

(2009) Minho Moon et al.   NEUROTOXICITY RESEARCH

Parkinson-Linked Genes and Toxins That Affect Neuronal Cell Death Through the Bcl-2 Family

(2008) Douglas W. Ethell et al.   ANTIOXIDANTS & REDOX SIGNALING

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Lipopolysaccharide Induces a Significant Increase in Expression of Iron Regulatory Hormone Hepcidin in the Cortex and Substantia Nigra in Rat Brain

(2008) Qin Wang et al.   ENDOCRINOLOGY

Non-motor symptoms in Parkinson’s disease

(2008) W. Poewe   EUROPEAN JOURNAL OF NEUROLOGY

Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy

(2008) Tim Hofer et al.   EXPERIMENTAL GERONTOLOGY

Age-related differences in NFκB translocation and Bcl-2/Bax ratio caused by TNFα and Abeta42 promote survival in middle-age neurons and death in old neurons

(2008) Jigisha R. Patel et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells

(2008) Francisco Molina-Holgado et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species

(2008) Dror Noy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Free Copper, Ferroxidase and SOD1 Activities, Lipid Peroxidation and NO x Content in the CSF. A Different Marker Profile in Four Neurodegenerative Diseases

(2008) Marie-Catherine Boll et al.   NEUROCHEMICAL RESEARCH

Iron Accumulation with Age, Oxidative Stress and Functional Decline

(2008) Jinze Xu et al.   PLoS One

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

(2008) S. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

(2008) W. S. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pesticide/Environmental Exposures and Parkinson's Disease in East Texas

(2008) Amanpreet S. Dhillon et al.   Journal of Agromedicine

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY

Alzheimer’s disease as copper deficiency

(2007) Leslie M. Klevay   MEDICAL HYPOTHESES

Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease

(2007) Li-Xing Liu et al.   NEUROSCIENCE RESEARCH