Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

Redox Signaling, Neuroinflammation, and Neurodegeneration

(2018) Gabriela Aguilera et al.   ANTIOXIDANTS & REDOX SIGNALING

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes

(2017) V. Ilievski et al.   JOURNAL OF PERIODONTAL RESEARCH

Sex Differences in Risk for Alzheimer’s Disease Related to Neurotrophin Gene Polymorphisms: The Cache County Memory Study

(2017) Joshua Matyi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sex differences in Alzheimer risk

(2017) Lisa Mosconi et al.   NEUROLOGY

Brain region- and sex-specific alterations in mitochondrial function and NF-κB signaling in the TgCRND8 mouse model of Alzheimer’s disease

(2017) Jelena Djordjevic et al.   NEUROSCIENCE

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

(2017) David C. Emery et al.   Frontiers in Aging Neuroscience

Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE–/– mice brains

(2017) Sim K. Singhrao et al.   Journal of Oral Microbiology

Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

(2017) Yicong Liu et al.   Scientific Reports

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Periodontitis prevalence in adults ≥ 65 years of age, in the USA

(2016) Paul I. Eke et al.   PERIODONTOLOGY 2000

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

(2016) Neil M O’Brien-Simpson et al.   npj Vaccines

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

Gamma Secretase-Activating Protein Is a Substrate for Caspase-3: Implications for Alzheimer’s Disease

(2015) Jin Chu et al.   BIOLOGICAL PSYCHIATRY

Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012

(2015) Paul I. Eke et al.   JOURNAL OF PERIODONTOLOGY

TLR4 Expression by Liver Resident Cells Mediates the Development of Glucose Intolerance and Insulin Resistance in Experimental Periodontitis

(2015) Vladimir Ilievski et al.   PLoS One

Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors

(2015) Katie J. Herbst-Robinson et al.   Scientific Reports

Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

(2015) Sasanka Chakrabarti et al.   Aging and Disease

Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

(2015) Guilian Xu et al.   Acta Neuropathologica Communications

Periodontal Health Condition in Patients With Alzheimer’s Disease

(2014) Santosh S. Martande et al.   American Journal of Alzheimers Disease and Other Dementias

Active Invasion of Oral and Aortic Tissues by Porphyromonas gingivalis in Mice Causally Links Periodontitis and Atherosclerosis

(2014) Irina M. Velsko et al.   PLoS One

Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota

(2014) Kei Arimatsu et al.   Scientific Reports

Detection of bacterial antigens and Alzheimer’s disease-like pathology in the central nervous system of BALB/c mice following intranasal infection with a laboratory isolate of Chlamydia pneumoniae

(2014) Christopher S. Little et al.   Frontiers in Aging Neuroscience

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Modeling Alzheimer’s Disease in Mouse without Mutant Protein Overexpression: Cooperative and Independent Effects of Aβ and Tau

(2013) Qinxi Guo et al.   PLoS One

Porphyromonas gingivalis influences actin degradation within epithelial cells during invasion and apoptosis

(2012) James A. Kinane et al.   CELLULAR MICROBIOLOGY

The role of astrocytes in amyloid β-protein toxicity and clearance

(2012) Dietmar Rudolf Thal   EXPERIMENTAL NEUROLOGY

Tooth Loss and Periodontitis in Older Individuals: Results From the Swedish National Study on Aging and Care

(2012) Stefan Renvert et al.   JOURNAL OF PERIODONTOLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

(2011) Judith Miklossy   Journal of Neuroinflammation

Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon’s knife to a meat chopper-like brutal degradation of proteins

(2010) Yonghua Guo et al.   PERIODONTOLOGY 2000

Periodontal innate immune mechanisms relevant to atherosclerosis and obesity

(2010) Sami A. Zelkha et al.   PERIODONTOLOGY 2000

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

(2009) Rong Yuan et al.   AGING CELL

Mouse model of experimental periodontitis induced byPorphyromonas gingivalis/Fusobacterium nucleatuminfection: bone loss and host response

(2009) David Polak et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III

(2009) J M Noble et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Periodontal bacteremia and various vascular diseases

(2009) T. Iwai   JOURNAL OF PERIODONTAL RESEARCH

Bacteremia Associated With Toothbrushing and Dental Extraction

(2008) Peter B. Lockhart et al.   CIRCULATION

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Interactions between APP secretases and inflammatory mediators

(2008) Magdalena Sastre et al.   Journal of Neuroinflammation

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Association Between Cognitive Function and Periodontal Disease in Older Adults

(2008) Yau-Hua Yu et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY