Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

(2021) Iain W. McNae et al.   Nature Communications

Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei

(2021) Maria Lucia Sampaio Guther et al.   PLoS Neglected Tropical Diseases

A Leap Into the Unknown – Early Events in African Trypanosome Transmission

(2020) Balázs Szöőr et al.   TRENDS IN PARASITOLOGY

Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi

(2020) Wilfredo Quiñones et al.   Frontiers in Cellular and Infection Microbiology

The Influence of Environmental Cues on the Development of Trypanosoma cruzi in Triatominae Vector

(2020) Raíssa de Fátima Pimentel Melo et al.   Frontiers in Cellular and Infection Microbiology

Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity

(2020) Ariely Barbosa Leite et al.   BIOCHEMICAL JOURNAL

ATP regulates the activity of an alternative oxidase in Trypanosoma brucei

(2020) Luis Alberto Luévano‐Martínez et al.   FEBS LETTERS

Landscapes of Protein Posttranslational Modifications of African Trypanosoma Parasites

(2020) Naiwen Zhang et al.   iScience

Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi

(2020) Isabel S. Shiratsubaki et al.   PLoS Neglected Tropical Diseases

Evolving Differentiation in African Trypanosomes

(2020) Juan F. Quintana et al.   TRENDS IN PARASITOLOGY

Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes

(2019) Héctor Acosta et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Positional Dynamics and Glycosomal Recruitment of Developmental Regulators during Trypanosome Differentiation

(2019) Balázs Szöőr et al.   mBio

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

(2019) M. Fleur Sernee et al.   Cell Host & Microbe

Quorum sensing in African trypanosomes

(2019) Federico Rojas et al.   CURRENT OPINION IN MICROBIOLOGY

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis

(2019) Peter M. Fernandes et al.   FEBS Journal

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

(2018) Bianca Zingales   ACTA TROPICA

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

(2018) Meng Yuan et al.   BIOCHEMICAL JOURNAL

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models

(2018) Eleanor C. Saunders et al.   MOLECULAR MICROBIOLOGY

Inorganic Polyphosphate Interacts with Nucleolar and Glycosomal Proteins in Trypanosomatids

(2018) Raquel S. Negreiros et al.   MOLECULAR MICROBIOLOGY

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

(2018) Peter M. Fernandes et al.   BIOCHEMICAL JOURNAL

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

(2018) Julie Kovářová et al.   PLoS Pathogens

Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: Analysis of metabolic adaptations on glycerol-rich conditions

(2018) Erika Pineda et al.   PLoS Pathogens

Gluconeogenesis is essential for trypanosome development in the tsetse fly vector

(2018) Marion Wargnies et al.   PLoS Pathogens

Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes

(2018) Yijian Qiu et al.   mSphere

Glycosomes: A comprehensive view of their metabolic roles in T. brucei

(2017) Stefan Allmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch inTrypanosoma cruziepimastigotes

(2017) María Julia Barisón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition

(2017) Meng Yuan et al.   JOURNAL OF MOLECULAR BIOLOGY

Comparative Proteomic Analysis of Lysine Acetylation in Trypanosomes

(2017) Nilmar Silvio Moretti et al.   JOURNAL OF PROTEOME RESEARCH

NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms

(2017) Sachin V. Surve et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

(2017) Laura Jeacock et al.   PLoS Pathogens

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

(2017) Alena Zíková et al.   PLoS Pathogens

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector

(2017) Brian S. Mantilla et al.   PLoS Pathogens

Transcriptomic analysis reveals metabolic switches and surface remodeling as key processes for stage transition in Trypanosoma cruzi

(2017) Luisa Berná et al.   PeerJ

Targeting pathogen metabolism without collateral damage to the host

(2017) Jurgen R. Haanstra et al.   Scientific Reports

Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites

(2016) Jurgen R. Haanstra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

African trypanosomes and brain infection - the unsolved question

(2016) Stefan Mogk et al.   BIOLOGICAL REVIEWS

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

(2016) Sandra Trindade et al.   Cell Host & Microbe

Targeting glycolysis in the malaria parasitePlasmodium falciparum

(2016) David D. van Niekerk et al.   FEBS Journal

The origin and evolution of the acidocalcisome and its interactions with other organelles

(2016) Roberto Docampo   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Peroxisomes in parasitic protists

(2016) Toni Gabaldón et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Trypanosoma cruzi contains two galactokinases; molecular and biochemical characterization

(2016) Ángel E. Lobo-Rojas et al.   PARASITOLOGY INTERNATIONAL

The Pentose Phosphate Pathway in Parasitic Trypanosomatids

(2016) Julie Kovářová et al.   TRENDS IN PARASITOLOGY

The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei

(2016) Manuel Saldivia et al.   Cell Reports

The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

(2016) Paul Capewell et al.   eLife

Glycosomal bromodomain factor 1 from Trypanosoma cruzi enhances trypomastigote cell infection and intracellular amastigote growth

(2015) C. Ritagliati et al.   BIOCHEMICAL JOURNAL

Leishmania major phosphoglycerate kinase transcript and protein stability contributes to differences in isoform expression levels

(2015) Aline Azevedo et al.   EXPERIMENTAL PARASITOLOGY

Molecular control of irreversible bistability during trypanosome developmental commitment

(2015) Maria Rosa Domingo-Sananes et al.   JOURNAL OF CELL BIOLOGY

Combining reverse genetics and nuclear magnetic resonance-based metabolomics unravels trypanosome-specific metabolic pathways

(2015) Frédéric Bringaud et al.   MOLECULAR MICROBIOLOGY

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose

(2015) Darren J. Creek et al.   PLoS Pathogens

Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling

(2015) Joachim Kloehn et al.   PLoS Pathogens

Glucose metabolism inTrypanosoma cruzi

(2015) Dante A. Maugeri et al.   Essays in Biochemistry

Glycosomal Targets for Anti-Trypanosomatid Drug Discovery

(2014) X. Barros-Alvarez et al.   CURRENT MEDICINAL CHEMISTRY

Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids

(2014) Balázs Szöör et al.   CURRENT OPINION IN MICROBIOLOGY

The phosphoglycerate kinase isoenzymes have distinct roles in the regulation of carbohydrate metabolism in Trypanosoma cruzi

(2014) Ximena Barros-Álvarez et al.   EXPERIMENTAL PARASITOLOGY

Contribution of Pyruvate Phosphate Dikinase in the Maintenance of the Glycosomal ATP/ADP Balance in theTrypanosoma bruceiProcyclic Form

(2014) Kamel Deramchia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Confidence Glycosome Proteome for Procyclic Form Trypanosoma brucei by Epitope-Tag Organelle Enrichment and SILAC Proteomics

(2014) Maria Lucia S. Güther et al.   JOURNAL OF PROTEOME RESEARCH

In or out? On the tightness of glycosomal compartmentalization of metabolites and enzymes in Trypanosoma brucei

(2014) Jurgen R. Haanstra et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase

(2014) Emmanuel Oluwadare Balogun et al.   MOLECULAR MICROBIOLOGY

Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

(2014) Eleanor C. Saunders et al.   PLoS Pathogens

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

(2014) H. P. Morgan et al.   Royal Society Open Science

`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator ofTrypanosoma bruceipyruvate kinase

(2013) Wenhe Zhong et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cytosolic NADPH Homeostasis in Glucose-starved ProcyclicTrypanosoma bruceiRelies on Malic Enzyme and the Pentose Phosphate Pathway Fed by Gluconeogenic Flux

(2013) Stefan Allmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Quantitative SILAC Phosphoproteomics Reveals Differential Phosphorylation Is Widespread between the Procyclic and Bloodstream Form Lifecycle Stages of Trypanosoma brucei

(2013) Michael D. Urbaniak et al.   JOURNAL OF PROTEOME RESEARCH

The Phosphoarginine Energy-Buffering System of Trypanosoma brucei Involves Multiple Arginine Kinase Isoforms with Different Subcellular Locations

(2013) Frank Voncken et al.   PLoS One

Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei

(2013) Eduard J. Kerkhoven et al.   PLoS Computational Biology

Revisiting the Central Metabolism of the Bloodstream Forms of Trypanosoma brucei: Production of Acetate in the Mitochondrion Is Essential for Parasite Viability

(2013) Muriel Mazet et al.   PLoS Neglected Tropical Diseases

Independent Pathways Can Transduce the Life-Cycle Differentiation Signal in Trypanosoma brucei

(2013) Balazs Szöőr et al.   PLoS Pathogens

Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

(2012) Arvind K Chavali et al.   BMC Systems Biology

Extra-glycosomal localisation of Trypanosoma brucei hexokinase 2

(2012) April C. Joice et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes

(2012) Jurgen R. Haanstra et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

ATP Synthesis-coupled and -uncoupled Acetate Production from Acetyl-CoA by Mitochondrial Acetate:Succinate CoA-transferase and Acetyl-CoA Thioesterase inTrypanosoma

(2012) Yoann Millerioux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

(2012) Giulia Bandini et al.   MOLECULAR MICROBIOLOGY

Alternative NADH dehydrogenase (NDH2): intermembrane-space-facing counterpart of mitochondrial complex I in the procyclic Trypanosoma brucei

(2012) ZDENĚK VERNER et al.   PARASITOLOGY

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei

(2012) Melisa Gualdron-López et al.   PLoS One

Comparative SILAC Proteomic Analysis of Trypanosoma brucei Bloodstream and Procyclic Lifecycle Stages

(2012) Michael D. Urbaniak et al.   PLoS One

Dynamic Modelling under Uncertainty: The Case of Trypanosoma brucei Energy Metabolism

(2012) Fiona Achcar et al.   PLoS Computational Biology

Arginine kinase in Phytomonas, a trypanosomatid parasite of plants

(2011) Gaspar E. Canepa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Multiple roles of proline transport and metabolism in trypanosomatids

(2011) Frederic Bringaud   Frontiers in Bioscience-Landmark

The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications

(2011) Bianca Zingales et al.   INFECTION GENETICS AND EVOLUTION

When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle

(2011) Melisa Gualdrón-López et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Glycerol 3-Phosphate AltersTrypanosoma bruceiHexokinase Activity in Response to Environmental Change

(2011) Heidi C. Dodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomic analysis of trypanosomatid protozoa

(2011) Darren J. Creek et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Methylglyoxal metabolism in trypanosomes and leishmania

(2011) Susan Wyllie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway

(2010) B. Szoor et al.   GENES & DEVELOPMENT

Complex I (NADH:ubiquinone oxidoreductase) is active in but non-essential for procyclic Trypanosoma brucei

(2010) Zdeněk Verner et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A domino effect in drug action: from metabolic assault towards parasite differentiation

(2010) Jurgen R. Haanstra et al.   MOLECULAR MICROBIOLOGY

The silicon trypanosome

(2010) BARBARA M. BAKKER et al.   PARASITOLOGY

Central carbon metabolism of Leishmania parasites

(2010) ELEANOR C. SAUNDERS et al.   PARASITOLOGY

Evidence That Intracellular Stages of Leishmania major Utilize Amino Sugars as a Major Carbon Source

(2010) Thomas Naderer et al.   PLoS Pathogens

Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites

(2009) Artur T. Cordeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi

(2009) Seth B Roberts et al.   BMC Systems Biology

Identification and Specific Localization of Tyrosine-Phosphorylated Proteins inTrypanosoma brucei

(2009) Isabelle R. E. Nett et al.   EUKARYOTIC CELL

Trypanosoma brucei AMP-activated kinase subunit homologs influence surface molecule expression

(2009) Clarice S. Clemmens et al.   EXPERIMENTAL PARASITOLOGY

The Phosphoproteome of Bloodstream FormTrypanosoma brucei, Causative Agent of African Sleeping Sickness

(2009) Isabelle R. E. Nett et al.   MOLECULAR & CELLULAR PROTEOMICS

Glucose uptake in the mammalian stages of Trypanosoma cruzi

(2009) Ariel M. Silber et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei

(2009) Ana Judith Cáceres et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The F0F1-ATP Synthase Complex Contains Novel Subunits and Is Essential for Procyclic Trypanosoma brucei

(2009) Alena Zíková et al.   PLoS Pathogens

Assembly of Heterohexameric Trypanosome Hexokinases Reveals That Hexokinase 2 Is a Regulable Enzyme

(2008) Jeremy W. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose-induced Remodeling of Intermediary and Energy Metabolism in ProcyclicTrypanosoma brucei

(2008) Virginie Coustou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major

(2008) Arvind K Chavali et al.   Molecular Systems Biology

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

(2008) J. R. Haanstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational modification of cellular proteins duringLeishmania donovani differentiation

(2008) Doron Rosenzweig et al.   PROTEOMICS

Retooling Leishmania metabolism: from sand fly gut to human macrophage

(2007) Doron Rosenzweig et al.   FASEB JOURNAL

Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei

(2007) Didier Vertommen et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY