Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role

Respiratory supercomplexes act as a platform for complex III ‐mediated maturation of human mitochondrial complexes I and IV

(2020) Margherita Protasoni et al.   EMBO JOURNAL

Cardiac Function is not Susceptible to Moderate Disassembly of Mitochondrial Respiratory Supercomplexes

(2020) Xavier R. Chapa-Dubocq et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rcf1 Modulates Cytochrome c Oxidase Activity Especially Under Energy-Demanding Conditions

(2020) Hannah Dawitz et al.   Frontiers in Physiology

Stable mitochondrial CICIII2 supercomplex interactions in reptiles compared to homeothermic vertebrates

(2020) Amanda Bundgaard et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

HIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV

(2020) Daniella H Hock et al.   MOLECULAR & CELLULAR PROTEOMICS

Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis

(2020) Alba Timón-Gómez et al.   Cell Reports

Mitochondria in Health and Diseases

(2020) Sabzali Javadov et al.   Cells

Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes

(2020) Teresa Lobo‐Jarne et al.   EMBO JOURNAL

Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Qpool

(2020) Enrique Calvo et al.   Science Advances

The yeast mitochondrial proteins Rcf1 and Rcf2 support the enzymology of the cytochrome c oxidase complex and generation of the proton motive force

(2019) Vera Strogolova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FMRpolyG alters mitochondrial transcripts level and respiratory chain complex assembly in Fragile X associated tremor/ataxia syndrome [FXTAS]

(2019) Dhruv Gohel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats

(2019) Rafael A. Casuso et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease

(2019) Karima Ait-Aissa et al.   Scientific Reports

Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational Crosstalk

(2019) James A. Letts et al.   MOLECULAR CELL

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure

(2019) Satoshi Maekawa et al.   Cell Communication and Signaling

Mitochondrial fragmentation, elevated mitochondrial superoxide and respiratory supercomplexes disassembly is connected with the tamoxifen-resistant phenotype of breast cancer cells

(2019) Veronika Tomková et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance

(2019) Kazuhiro Ikeda et al.   Nature Communications

The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells

(2019) Rebecca M. Parodi-Rullán et al.   Cells

OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling

(2019) Sehwan Jang et al.   MITOCHONDRION

NGL viewer: web-based molecular graphics for large complexes

(2018) Alexander S Rose et al.   BIOINFORMATICS

Mitochondrial Supercomplexes Do Not Enhance Catalysis by Quinone Channeling

(2018) Justin G. Fedor et al.   Cell Metabolism

The Organization of Mitochondrial Supercomplexes is Modulated by Oxidative Stress In Vivo in Mouse Models of Mitochondrial Encephalopathy

(2018) Mir Anwar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Different approaches to modeling analysis of mitochondrial swelling

(2018) Sabzali Javadov et al.   MITOCHONDRION

Respiratory chain supercomplexes: Structures, function and biogenesis

(2018) Teresa Lobo-Jarne et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Current Challenges in Elucidating Respiratory Supercomplexes in Mitochondria: Methodological Obstacles

(2018) Sehwan Jang et al.   Frontiers in Physiology

Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue

(2018) Juan D. Chavez et al.   Cell Systems

p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells

(2018) Hidekazu Nagano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Open questions: respiratory chain supercomplexes—why are they there and what do they do?

(2018) Judy Hirst   BMC BIOLOGY

Cardioprotective strategies preserve the stability of respiratory chain supercomplexes and reduce oxidative stress in reperfused ischemic hearts

(2018) I. Ramírez-Camacho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria

(2018) Sehwan Jang et al.   Scientific Reports

Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics

(2018) Teresa Lobo-Jarne et al.   Cell Reports

Deficiency of PHB complex impairs respiratory supercomplex formation and activates mitochondrial flashes

(2017) Chongshu Jian et al.   JOURNAL OF CELL SCIENCE

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes

(2017) Fan Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

(2017) James A Letts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants

(2017) Irene Lopez-Fabuel et al.   NEUROCHEMISTRY INTERNATIONAL

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

(2017) James A Letts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of Mammalian Respiratory Supercomplex I 1 III 2 IV 1

(2016) Meng Wu et al.   CELL

Mitochondrial Metabolism in Aging Heart

(2016) Edward J. Lesnefsky et al.   CIRCULATION RESEARCH

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i ‐AAA protease YME1L

(2016) Timothy Wai et al.   EMBO REPORTS

The architecture of respiratory supercomplexes

(2016) James A. Letts et al.   NATURE

The architecture of the mammalian respirasome

(2016) Jinke Gu et al.   NATURE

Mechanism of super-assembly of respiratory complexes III and IV

(2016) Sara Cogliati et al.   NATURE

Accessory subunits are integral for assembly and function of human mitochondrial complex I

(2016) David A. Stroud et al.   NATURE

Loss of protein association causes cardiolipin degradation in Barth syndrome

(2016) Yang Xu et al.   Nature Chemical Biology

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

(2016) Irene Lopez-Fabuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems proteomics of liver mitochondria function

(2016) E. G. Williams et al.   SCIENCE

COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy

(2016) Kezhong Zhang et al.   Scientific Reports

COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation

(2016) Rafael Pérez-Pérez et al.   Cell Reports

Functional asymmetry and electron flow in the bovine respirasome

(2016) Joana S Sousa et al.   eLife

Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians

(2016) Gianluca Sgarbi et al.   Aging-US

Isoflurane Protects the Myocardium Against Ischemic Injury via the Preservation of Mitochondrial Respiration and Its Supramolecular Organization

(2015) Christopher Lotz et al.   ANESTHESIA AND ANALGESIA

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

(2015) Ghadi Antoun et al.   DIABETOLOGIA

Stomatin-Like Protein 2 Is Required forIn VivoMitochondrial Respiratory Chain Supercomplex Formation and Optimal Cell Function

(2015) Panagiotis Mitsopoulos et al.   MOLECULAR AND CELLULAR BIOLOGY

C11orf83, a Mitochondrial Cardiolipin-Binding Protein Involved inbc1Complex Assembly and Supercomplex Stabilization

(2015) Marjorie Desmurs et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats

(2015) Sabzali Javadov et al.   Oncotarget

Cardiac Metabolic Pathways Affected in the Mouse Model of Barth Syndrome

(2015) Yan Huang et al.   PLoS One

The Respiratory Chain Supercomplex Organization Is Independent of COX7a2l Isoforms

(2014) Arnaud Mourier et al.   Cell Metabolism

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

(2014) D. A. Patten et al.   EMBO JOURNAL

Uniform nomenclature for the mitochondrial contact site and cristae organizing system

(2014) Nikolaus Pfanner et al.   JOURNAL OF CELL BIOLOGY

Lipid14: The Amber Lipid Force Field

(2014) Callum J. Dickson et al.   Journal of Chemical Theory and Computation

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

9-Methyl-β-carboline has restorative effects in an animal model of Parkinson’s disease

(2014) Catrin Wernicke et al.   Pharmacological Reports

Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes

(2014) J. N. Blaza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I

(2013) Evelina Maranzana et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

MCJ/DnaJC15, an Endogenous Mitochondrial Repressor of the Respiratory Chain That Controls Metabolic Alterations

(2013) K. M. Hatle et al.   MOLECULAR AND CELLULAR BIOLOGY

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle

(2013) Kazuhiro Ikeda et al.   Nature Communications

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain

(2012) Eduardo Balsa et al.   Cell Metabolism

Identification of a Protein Mediating Respiratory Supercomplex Stability

(2012) Yu-Chan Chen et al.   Cell Metabolism

Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex

(2012) Milena Vukotic et al.   Cell Metabolism

Cardiolipin-dependent Reconstitution of Respiratory Supercomplexes from PurifiedSaccharomyces cerevisiaeComplexes III and IV

(2012) Soledad Bazán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restricted diffusion of OXPHOS complexes in dynamic mitochondria delays their exchange between cristae and engenders a transitory mosaic distribution

(2012) Verena Wilkens et al.   JOURNAL OF CELL SCIENCE

Phosphatidylethanolamine and Cardiolipin Differentially Affect the Stability of Mitochondrial Respiratory Chain Supercomplexes

(2012) Lena Böttinger et al.   JOURNAL OF MOLECULAR BIOLOGY

Rcf1 and Rcf2, Members of the Hypoxia-Induced Gene 1 Protein Family, Are Critical Components of the Mitochondrial Cytochrome bc1-Cytochrome c Oxidase Supercomplex

(2012) V. Strogolova et al.   MOLECULAR AND CELLULAR BIOLOGY

Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine

(2011) Ashish K. Gadicherla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1

(2011) Thorsten Althoff et al.   EMBO JOURNAL

The redox stress hypothesis of aging

(2011) Rajindar S. Sohal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial complex III stabilizes complex I in the absence of NDUFS4 to provide partial activity

(2011) M. A. Calvaruso et al.   HUMAN MOLECULAR GENETICS

Biphasic response of skeletal muscle mitochondria to chronic cardiac pressure overload — Role of respiratory chain complex activity

(2011) Andrea Schrepper et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cells Lacking Rieske Iron-Sulfur Protein Have a Reactive Oxygen Species-Associated Decrease in Respiratory Complexes I and IV

(2011) F. Diaz et al.   MOLECULAR AND CELLULAR BIOLOGY

Stomatin-Like Protein 2 Binds Cardiolipin and Regulates Mitochondrial Biogenesis and Function

(2011) D. A. Christie et al.   MOLECULAR AND CELLULAR BIOLOGY

Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography

(2011) N. V. Dudkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macromolecular organization of ATP synthase and complex I in whole mitochondria

(2011) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased cytochromecmediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria

(2010) John F. O'Toole et al.   BIOCHEMICAL JOURNAL

Ageing alters the supramolecular architecture of OxPhos complexes in rat brain cortex

(2010) Monika Frenzel et al.   EXPERIMENTAL GERONTOLOGY

Characterization of a Transgenic Short Hairpin RNA-Induced Murine Model of Tafazzin Deficiency

(2010) Meghan S. Soustek et al.   HUMAN GENE THERAPY

Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

(2010) Devrim Acehan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection leads to novel changes in the mitochondrial proteome

(2009) Renee Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart

(2009) Luis A. Gómez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial Cardiolipin Involved in Outer-Membrane Protein Biogenesis: Implications for Barth Syndrome

(2009) Natalia Gebert et al.   CURRENT BIOLOGY

Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria

(2009) Michael Lazarou et al.   FEBS Journal

Prohibitins and the functional compartmentalization of mitochondrial membranes

(2009) C. Osman et al.   JOURNAL OF CELL SCIENCE

Defining the transcriptomic and proteomic profiles of rat ageing skeletal muscle by the use of a cDNA array, 2D- and Blue native-PAGE approach

(2009) A. Lombardi et al.   Journal of Proteomics

The structure of eukaryotic and prokaryotic complex I

(2009) T. Clason et al.   JOURNAL OF STRUCTURAL BIOLOGY

Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance

(2009) Charles R Arthur et al.   Molecular Neurodegeneration

Pathophysiology of mitochondrial volume homeostasis: Potassium transport and permeability transition

(2008) Karin Nowikovsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

(2008) Mariana G. Rosca et al.   CARDIOVASCULAR RESEARCH

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL