Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei

The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei

(2017) Ebony Weems et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase

(2017) Christoph Wenger et al.   PLoS Pathogens

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

(2016) Anke Harsman et al.   Nature Communications

Fe/S protein biogenesis in trypanosomes — A review

(2015) Julius Lukeš et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1

(2015) Michael P. Spiller et al.   BIOSCIENCE REPORTS

Functional Complementation Analyses Reveal that the Single PRAT Family Protein of Trypanosoma brucei Is a Divergent Homolog of Tim17 in Saccharomyces cerevisiae

(2015) Ebony Weems et al.   EUKARYOTIC CELL

Tim62, a Novel Mitochondrial Protein inTrypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex

(2015) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances

(2015) Jan Mani et al.   Nature Communications

Mitochondrial calcium transport in trypanosomes

(2014) Roberto Docampo et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Biogenesis of mitochondrial carrier proteins: Molecular mechanisms of import into mitochondria

(2012) Alessandra Ferramosca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries

(2012) Elisabeth Eckers et al.   BIOLOGICAL CHEMISTRY

Protein Translocase of Mitochondrial Inner Membrane inTrypanosoma brucei

(2012) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase

(2012) Anke Harsman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polypeptide Translocation Through the Mitochondrial TOM Channel: Temperature-Dependent Rates at the Single-Molecule Level

(2012) Kozhinjampara R. Mahendran et al.   Journal of Physical Chemistry Letters

Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)

(2012) Peter GE Kennedy   LANCET NEUROLOGY

Architecture of the trypanosome RNA editing accessory complex, MRB1

(2012) Michelle L. Ammerman et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin

(2011) Mascha Pusnik et al.   CURRENT BIOLOGY

Trypanosoma bruceiMitochondrial Respiratome: Composition and Organization in Procyclic Form

(2011) Nathalie Acestor et al.   MOLECULAR & CELLULAR PROTEOMICS

Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective

(2010) Nicolas Guex et al.   ELECTROPHORESIS

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A spectrum of disease in Human African trypanosomiasis: the host and parasite genetics of virulence

(2010) JEREMY M. STERNBERG et al.   PARASITOLOGY

Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

(2010) S. A. Hasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Downregulation of Mitochondrial Porin Inhibits Cell Growth and Alters Respiratory Phenotype inTrypanosoma brucei

(2009) Ujjal K. Singha et al.   EUKARYOTIC CELL

Distinct Forms of Mitochondrial TOM-TIM Supercomplexes Define Signal-Dependent States of Preprotein Sorting

(2009) A. Chacinska et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein composition of Trypanosoma brucei mitochondrial membranes

(2009) Nathalie Acestor et al.   PROTEOMICS

Multiple pathways for sorting mitochondrial precursor proteins

(2008) Natalia Bolender et al.   EMBO REPORTS

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase

(2008) Natalia Gebert et al.   EMBO REPORTS

Host genetics in African trypanosomiasis

(2008) David Courtin et al.   INFECTION GENETICS AND EVOLUTION

The Essential Function of Tim12in VivoIs Ensured by the Assembly Interactions of Its C-terminal Domain

(2008) Eirini Lionaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric and Electrostatic Protein–Protein Interactions Regulate the Assembly of the Heterohexameric Tim9–Tim10 Complex

(2008) Ekaterina Ivanova et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei

(2008) Ujjal K. Singha et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Single Mitochondrial Porin of Trypanosoma brucei is the Main Metabolite Transporter in the Outer Mitochondrial Membrane

(2008) M. Pusnik et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structural and Functional Requirements for Activity of the Tim9–Tim10 Complex in Mitochondrial Protein Import

(2008) Michael J. Baker et al.   MOLECULAR BIOLOGY OF THE CELL

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH