Mitochondrial protein import in trypanosomes: Expect the unexpected

A Eukaryote without a Mitochondrial Organelle

(2016) Anna Karnkowska et al.   CURRENT BIOLOGY

TbLOK1/ATOM19 is a novel subunit of the noncanonical mitochondrial outer membrane protein translocase ofTrypanosoma brucei

(2016) Silvia Desy et al.   MOLECULAR MICROBIOLOGY

Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria

(2016) Sandro Käser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

(2016) Anke Harsman et al.   Nature Communications

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

(2016) Yilin Kang et al.   eLife

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

Functional Complementation Analyses Reveal that the Single PRAT Family Protein of Trypanosoma brucei Is a Divergent Homolog of Tim17 in Saccharomyces cerevisiae

(2015) Ebony Weems et al.   EUKARYOTIC CELL

Biogenesis of beta-barrel proteins in evolutionary context

(2015) Thomas Ulrich et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Tim62, a Novel Mitochondrial Protein inTrypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex

(2015) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sam37 is crucial for formation of the mitochondrial TOM–SAM supercomplex, thereby promoting β-barrel biogenesis

(2015) Lena-Sophie Wenz et al.   JOURNAL OF CELL BIOLOGY

Peeping at TOMs—Diverse Entry Gates to Mitochondria Provide Insights into the Evolution of Eukaryotes

(2015) Jan Mani et al.   MOLECULAR BIOLOGY AND EVOLUTION

Unlocking the presequence import pathway

(2015) Christian Schulz et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Heat Shock Protein Machinery Hsp70/Hsp40 Is Indispensable for Proper Mitochondrial DNA Maintenance and Replication

(2015) Jiří Týč et al.   mBio

Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances

(2015) Jan Mani et al.   Nature Communications

Trypanosome RNA editing: the complexity of getting U in and taking U out

(2015) Laurie K. Read et al.   Wiley Interdisciplinary Reviews-RNA

Beyond replication: Division and segregation of mitochondrial DNA in kinetoplastids

(2014) Megan L. Povelones   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Unraveling the Intricate Organization of Mammalian Mitochondrial Presequence Translocases: Existence of Multiple Translocases for Maintenance of Mitochondrial Function

(2014) D. Sinha et al.   MOLECULAR AND CELLULAR BIOLOGY

Mgr2 Functions as Lateral Gatekeeper for Preprotein Sorting in the Mitochondrial Inner Membrane

(2014) Raffaele Ieva et al.   MOLECULAR CELL

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MPIC: A Mitochondrial Protein Import Components Database for Plant and Non-Plant Species

(2014) Monika W. Murcha et al.   PLANT AND CELL PHYSIOLOGY

Evolutionary cell biology: Two origins, one objective: Fig. 1.

(2014) Michael Lynch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trypanosomal TAC40 constitutes a novel subclass of mitochondrial  -barrel proteins specialized in mitochondrial genome inheritance

(2014) F. Schnarwiler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell cycle-dependent regulation of mitochondrial preprotein translocase

(2014) A. B. Harbauer et al.   SCIENCE

The Eukaryotic Tree of Life from a Global Phylogenomic Perspective

(2014) F. Burki   Cold Spring Harbor Perspectives in Biology

Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation

(2014) Christian Schulz et al.   Nature Communications

Symbiogenesis: Mechanisms, Evolutionary Consequences, and Systematic Implications

(2013) Thomas Cavalier-Smith   Annual Review of Ecology Evolution and Systematics

Bioinformatics perspective on rhomboid intramembrane protease evolution and function

(2013) Lisa N. Kinch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa

(2013) Takashi Makiuchi et al.   BIOCHIMIE

Signal recognition initiates reorganization of the presequence translocase during protein import

(2013) Oleksandr Lytovchenko et al.   EMBO JOURNAL

The Ancient and Widespread Nature of the ER–Mitochondria Encounter Structure

(2013) Jeremy G. Wideman et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mitochondrial shape and function in trypanosomes requires the outer membrane protein, TbLOK1

(2013) Megan L. Povelones et al.   MOLECULAR MICROBIOLOGY

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

(2013) Martin Mehnert et al.   NATURE CELL BIOLOGY

Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes

(2013) Samuel Dean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network News: The Replication of Kinetoplast DNA

(2012) Robert E. Jensen et al.   Annual Review of Microbiology

Mitochondrial protein import: Common principles and physiological networks

(2012) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries

(2012) Elisabeth Eckers et al.   BIOLOGICAL CHEMISTRY

Tom40 is likely common to all mitochondria

(2012) Vojtech Zarsky et al.   CURRENT BIOLOGY

Divergence of Erv1-Associated Mitochondrial Import and Export Pathways in Trypanosomes and Anaerobic Protists

(2012) Somsuvro Basu et al.   EUKARYOTIC CELL

Divergent Molecular Evolution of the Mitochondrial Sulfhydryl:CytochromecOxidoreductase Erv in Opisthokonts and Parasitic Protists

(2012) Elisabeth Eckers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Translocase of Mitochondrial Inner Membrane inTrypanosoma brucei

(2012) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim50 inTrypanosoma bruceiPossesses a Dual Specificity Phosphatase Activity and Is Critical for Mitochondrial Protein Import

(2012) Melanie R. Duncan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase

(2012) Anke Harsman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes

(2012) Michael Gebert et al.   JOURNAL OF CELL BIOLOGY

A crucial role for Mim2 in the biogenesis of mitochondrial outer membrane proteins

(2012) K. S. Dimmer et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Outer Membrane Proteome ofTrypanosoma bruceiReveals Novel Factors Required to Maintain Mitochondrial Morphology

(2012) Moritz Niemann et al.   MOLECULAR & CELLULAR PROTEOMICS

An essential novel component of the noncanonical mitochondrial outer membrane protein import system of trypanosomatids

(2012) Mascha Pusnik et al.   MOLECULAR BIOLOGY OF THE CELL

Evolutionary cell biology: Lessons from diversity

(2012) Frances M. Brodsky et al.   NATURE CELL BIOLOGY

Mitochondrial tRNA Import and Its Consequences for Mitochondrial Translation

(2011) André Schneider   Annual Review of Biochemistry

Regulation of Mitochondrial Protein Import by Cytosolic Kinases

(2011) Oliver Schmidt et al.   CELL

Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin

(2011) Mascha Pusnik et al.   CURRENT BIOLOGY

In vivo study in Trypanosoma brucei links mitochondrial transfer RNA import to mitochondrial protein import

(2011) Florence Tschopp et al.   EMBO REPORTS

Mitochondrial Disulfide Relay: Redox-regulated Protein Import into the Intermembrane Space

(2011) Johannes M. Herrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reevaluation of the role of the Pam18:Pam16 interaction in translocation of proteins by the mitochondrial Hsp70-based import motor

(2011) June E. Pais et al.   MOLECULAR BIOLOGY OF THE CELL

Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane

(2011) Natalia Gebert et al.   MOLECULAR CELL

The Neurospora crassa TOB Complex: Analysis of the Topology and Function of Tob38 and Tob37

(2011) Sebastian W. K. Lackey et al.   PLoS One

In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work

(2011) T. Shiota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An in silico analysis of the mitochondrial protein import apparatus of plants

(2010) Chris Carrie et al.   BMC PLANT BIOLOGY

Biogenesis of Mitochondria: Dual Role of Tom7 in Modulating Assembly of the Preprotein Translocase of the Outer Membrane

(2010) Thomas Becker et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei

(2010) Shvetank Sharma et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A Functional Tom70 in the Human Parasite Blastocystis sp.: Implications for the Evolution of the Mitochondrial Import Apparatus

(2010) A. D. Tsaousis et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

(2010) Koyeli Mapa et al.   MOLECULAR CELL

The energetics of genome complexity

(2010) Nick Lane et al.   NATURE

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes

(2010) T. Lithgow et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

The enigmatic role of Mim1 in mitochondrial biogenesis

(2009) Kai Stefan Dimmer et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Genetic and Functional Interactions between the Mitochondrial Outer Membrane Proteins Tom6 and Sam37

(2009) J. Dukanovic et al.   MOLECULAR AND CELLULAR BIOLOGY

ERAD-Derived Preprotein Transport across the Second Outermost Plastid Membrane of Diatoms

(2009) F. Hempel et al.   MOLECULAR BIOLOGY AND EVOLUTION

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

(2009) Dejana Mokranjac et al.   MOLECULAR BIOLOGY OF THE CELL

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Dissecting Membrane Insertion of Mitochondrial β-Barrel Proteins

(2008) Stephan Kutik et al.   CELL

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase

(2008) Natalia Gebert et al.   EMBO REPORTS

Distinctive biochemistry in the trypanosome mitochondrial intermembrane space suggests a model for stepwise evolution of the MIA pathway for import of cysteine-rich proteins

(2008) James W.A. Allen et al.   FEBS LETTERS

Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei

(2008) Ujjal K. Singha et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Assembly Pathway of the Mitochondrial Carrier Translocase Involves Four Preprotein Translocases

(2008) K. Wagner et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Protein Import Motor: Differential Role of Tim44 in the Recruitment of Pam17 and J-Complex to the Presequence Translocase

(2008) Dana P. Hutu et al.   MOLECULAR BIOLOGY OF THE CELL

Structure, topology and function of the translocase of the outer membrane of mitochondria

(2008) Andrew J. Perry et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

The direct route: a simplified pathway for protein import into the mitochondrion of trypanosomes

(2008) André Schneider et al.   TRENDS IN CELL BIOLOGY

Mim1 Functions in an Oligomeric Form to Facilitate the Integration of Tom20 into the Mitochondrial Outer Membrane

(2007) Jelena Popov-Čeleketić et al.   JOURNAL OF MOLECULAR BIOLOGY

The Peripheral Membrane Subunits of the SAM Complex Function Codependently in Mitochondrial Outer Membrane Biogenesis

(2007) Nickie C. Chan et al.   MOLECULAR BIOLOGY OF THE CELL