Human HAD phosphatases: structure, mechanism, and roles in health and disease

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Selective Inactivation of a Human Neuronal Silencing Phosphatase by a Small Molecule Inhibitor

(2011) Mengmeng Zhang et al.   ACS Chemical Biology

Homo sapiensDullard Protein Phosphatase Shows a Preference for the Insulin-Dependent Phosphorylation Site of Lipin1

(2011) Rui Wu et al.   BIOCHEMISTRY

Soluble Epoxide Hydrolase Inhibitors and their Potential for Treatment of Multiple Pathologic Conditions

(2011) R. H. Ingraham et al.   CURRENT MEDICINAL CHEMISTRY

Premature aging and cancer in nucleotide excision repair-disorders

(2011) K. Diderich et al.   DNA REPAIR

To live or to die: a matter of processing damaged DNA termini in neurons

(2011) Sherif F. El-Khamisy   EMBO Molecular Medicine

A new face and new challenges for Online Mendelian Inheritance in Man (OMIM®)

(2011) Joanna Amberger et al.   HUMAN MUTATION

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

The case for locus-specific databases

(2011) Mark E. Samuels et al.   NATURE REVIEWS GENETICS

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

(2011) Michael Weinfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lipins: Multifunctional Lipid Metabolism Proteins

(2010) Lauren S. Csaki et al.   Annual Review of Nutrition

HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5′-phosphatase

(2010) Alice Preumont et al.   BIOCHEMICAL JOURNAL

Divergence of Biochemical Function in the HAD Superfamily:d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB)

(2010) Liangbing Wang et al.   BIOCHEMISTRY

Evolutionary History and Functional Diversification of Phosphomannomutase Genes

(2010) Rita Quental et al.   JOURNAL OF MOLECULAR EVOLUTION

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

(2010) Chiara Rampazzo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

(2010) Jun Shen et al.   NATURE GENETICS

The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration and invasion of tumor cells

(2010) R N Pandey et al.   ONCOGENE

The clinical spectrum of phosphomannomutase 2 deficiency (CDG-Ia)

(2009) Stephanie Grünewald   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification of a Small Molecule Inhibitor of the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase

(2009) G. K. Freschauf et al.   CANCER RESEARCH

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

The lipin family: mutations and metabolism

(2009) Karen Reue   CURRENT OPINION IN LIPIDOLOGY

Markers of fitness in a successful enzyme superfamily

(2009) Karen N Allen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

(2009) Suk-Kyeong Jung et al.   FASEB JOURNAL

Dephosphorylation of the C-terminal Tyrosyl Residue of the DNA Damage-related Histone H2A.X Is Mediated by the Protein Phosphatase Eyes Absent

(2009) Navasona Krishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

(2009) Erica L. McCoy et al.   JOURNAL OF CLINICAL INVESTIGATION

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling

(2009) Douglas S. Micalizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

l-Serine synthesis in the central nervous system: A review on serine deficiency disorders

(2009) L. Tabatabaie et al.   MOLECULAR GENETICS AND METABOLISM

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

(2009) John D. Imig et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis

(2009) S J Miller et al.   ONCOGENE

Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood

(2008) Avraham Zeharia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of a Polymorphism in the Lipin 1 Gene With Systolic Blood Pressure in Men

(2008) K. L. Ong et al.   AMERICAN JOURNAL OF HYPERTENSION

Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble Epoxide Hydrolase

(2008) Ahmed E. EnayetAllah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Analysis of 2-Keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate Phosphatase Defines Specificity Elements in Type C0 Haloalkanoate Dehalogenase Family Members

(2008) Zhibing Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Phosphomannomutase PMM1 Is the Brain IMP-sensitive Glucose-1,6-bisphosphatase

(2008) Maria Veiga-da-Cunha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation

(2008) Yadi Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Phosphatases and a Phospho-Degron Are Critical for Regulation of SRC-3/AIB1 Coactivator Function and Turnover

(2008) Chao Li et al.   MOLECULAR CELL

The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

(2008) Agnidipta Ghosh et al.   MOLECULAR CELL

LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients

(2008) Eun Seok Kang et al.   MOLECULAR GENETICS AND METABOLISM

Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression

(2008) C D Neff et al.   MOLECULAR PSYCHIATRY

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease

(2008) Jan Monti et al.   NATURE GENETICS

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY