Building Better Barrels – β-barrel Biogenesis and Insertion in Bacteria and Mitochondria

Mitochondrial sorting and assembly machinery operates by β-barrel switching

(2021) Hironori Takeda et al.   NATURE

Toc75‐V/OEP80 is processed during translocation into chloroplasts, and the membrane‐embedded form exposes its POTRA domain to the intermembrane space

(2020) Lucia E. Gross et al.   FEBS Open Bio

Structure of a nascent membrane protein as it folds on the BAM complex

(2020) David Tomasek et al.   NATURE

Structural insight into mitochondrial β-barrel outer membrane protein biogenesis

(2020) Kathryn A. Diederichs et al.   Nature Communications

Single-particle cryo-EM at atomic resolution

(2020) Takanori Nakane et al.   NATURE

Atomic-resolution protein structure determination by cryo-EM

(2020) Ka Man Yip et al.   NATURE

Cryo-electron microscopy reaches atomic resolution

(2020) Mark A. Herzik Jr   NATURE

Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology

(2020) Sahar Elouej et al.   Nature Communications

Atomic structure of human TOM core complex

(2020) Wenhe Wang et al.   Cell Discovery

Structures of the β‐barrel assembly machine recognizing outer membrane protein substrates

(2020) Le Xiao et al.   FASEB JOURNAL

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The PSIPRED Protein Analysis Workbench: 20 years on

(2019) Daniel W A Buchan et al.   NUCLEIC ACIDS RESEARCH

Bacterial outer membrane proteins assemble via asymmetric interactions with the BamA β-barrel

(2019) Matthew T. Doyle et al.   Nature Communications

The big BAM theory: An open and closed case?

(2019) Runrun Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Coupling of import and assembly pathways in mitochondrial protein biogenesis

(2019) Alexander Grevel et al.   BIOLOGICAL CHEMISTRY

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

(2019) Anatol Luther et al.   NATURE

A new antibiotic selectively kills Gram-negative pathogens

(2019) Yu Imai et al.   NATURE

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

(2019) Elizabeth M. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep learning extends de novo protein modelling coverage of genomes using iteratively predicted structural constraints

(2019) Joe G. Greener et al.   Nature Communications

Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

(2019) James Lee et al.   eLife

Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population

(2018) Goh Eun Chung et al.   Gut and Liver

Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion

(2018) James Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane protein insertion through a mitochondrial β-barrel gate

(2018) Alexandra I. C. Höhr et al.   SCIENCE

The WD40 Protein BamB Mediates Coupling of BAM Complexes into Assembly Precincts in the Bacterial Outer Membrane

(2018) Sachith D. Gunasinghe et al.   Cell Reports

Sequence-Specific Solution NMR Assignments of the β-Barrel Insertase BamA to Monitor Its Conformational Ensemble at the Atomic Level

(2018) Jean-Baptiste Hartmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C-terminal kink formation is required for lateral gating in BamA

(2018) Karl Lundquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 9 secretion system structures reveal a new protein transport mechanism

(2018) Frédéric Lauber et al.   NATURE

Structural and functional insights into the role of BamD and BamE within the β-barrel assembly machinery inNeisseria gonorrhoeae

(2017) Aleksandra E. Sikora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

The β-barrel assembly machinery in motion

(2017) Nicholas Noinaj et al.   NATURE REVIEWS MICROBIOLOGY

The POTRA domains of Toc75 exhibit chaperone-like function to facilitate import into chloroplasts

(2017) Patrick K. O’Neil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flexibility in the Periplasmic Domain of BamA Is Important for Function

(2017) Lisa R. Warner et al.   STRUCTURE

Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale

(2017) Marcel Morgenstern et al.   Cell Reports

Novel Kinetic Intermediates Populated along the Folding Pathway of the Transmembrane β-Barrel OmpA

(2016) Emily J. Danoff et al.   BIOCHEMISTRY

Structural basis of outer membrane protein insertion by the BAM complex

(2016) Yinghong Gu et al.   NATURE

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins

(2016) Long Han et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of a stalled complex on the β-barrel assembly machine

(2016) James Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the  -barrel assembly machinery complex

(2016) J. Bakelar et al.   SCIENCE

The Structure of a BamA-BamD Fusion Illuminates the Architecture of the β-Barrel Assembly Machine Core

(2016) Hans Thor Bergal et al.   STRUCTURE

From Chaperones to the Membrane with a BAM!

(2016) Ashlee M. Plummer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10

(2016) Lars Ellenrieder et al.   Nature Communications

Characterization of the targeting signal in mitochondrial β-barrel proteins

(2016) Tobias Jores et al.   Nature Communications

Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM

(2016) Matthew G. Iadanza et al.   Nature Communications

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins

(2016) Long Han et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TheKlebsiella pneumoniaeYfgL (BamB) lipoprotein contributes to outer membrane protein biogenesis, type-1 fimbriae expression, anti-phagocytosis, andin vivovirulence

(2016) Pei-Fang Hsieh et al.   Virulence

Structural basis for the interaction of BamB with the POTRA3–4 domains of BamA

(2016) Zhen Chen et al.   Acta Crystallographica Section D-Structural Biology

Mitochondrial-bacterial hybrids of BamA/Tob55 suggest variable requirements for the membrane integration of β-barrel proteins

(2016) Anna-Katharina Pfitzner et al.   Scientific Reports

Fitting the Pieces of the β-Barrel Assembly Machinery Complex

(2015) Patrick K. O’Neil et al.   BIOCHEMISTRY

The styrene–maleic acid copolymer: a versatile tool in membrane research

(2015) Jonas M. Dörr et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Genetic Variants in the SAMM50 Gene Create Susceptibility to Nonalcoholic Fatty Liver Disease in a Chinese Han Population

(2015) Lizhen Chen et al.   Hepatitis Monthly

Biogenesis of beta-barrel proteins in evolutionary context

(2015) Thomas Ulrich et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Sam37 is crucial for formation of the mitochondrial TOM–SAM supercomplex, thereby promoting β-barrel biogenesis

(2015) Lena-Sophie Wenz et al.   JOURNAL OF CELL BIOLOGY

Molecular architecture of the active mitochondrial protein gate

(2015) T. Shiota et al.   SCIENCE

Membrane Defects Accelerate Outer Membrane β-Barrel Protein Folding

(2014) Emily J. Danoff et al.   BIOCHEMISTRY

Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli

(2014) Dongchun Ni et al.   FASEB JOURNAL

Crystal Structure of BamB Bound to a Periplasmic Domain Fragment of BamA, the Central Component of the β-Barrel Assembly Machine

(2014) Katarina Bartoš Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary Conservation in Biogenesis of β-Barrel Proteins Allows Mitochondria to Assemble a Functional Bacterial Trimeric Autotransporter Protein

(2014) Thomas Ulrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Outer membrane  -barrel protein folding is physically controlled by periplasmic lipid head groups and BamA

(2014) D. Gessmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lateral Opening and Exit Pore Formation Are Required for BamA Function

(2014) Nicholas Noinaj et al.   STRUCTURE

Protein Targeting and Transport as a Necessary Consequence of Increased Cellular Complexity

(2014) M. S. Sommer et al.   Cold Spring Harbor Perspectives in Biology

Bioenergetic Constraints on the Evolution of Complex Life

(2014) N. Lane   Cold Spring Harbor Perspectives in Biology

The Dispersed Archaeal Eukaryome and the Complex Archaeal Ancestor of Eukaryotes

(2014) E. V. Koonin et al.   Cold Spring Harbor Perspectives in Biology

Translocation path of a substrate protein through its Omp85 transporter

(2014) Catherine Baud et al.   Nature Communications

A comprehensive analysis of the Omp85/TpsB protein superfamily structural diversity, taxonomic occurrence, and evolution

(2014) Eva Heinz et al.   Frontiers in Microbiology

Structure of BamA, an essential factor in outer membrane protein biogenesis

(2014) Reinhard Albrecht et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation

(2013) Jian Qiu et al.   CELL

Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan

(2013) Takuya Kitamoto et al.   HUMAN GENETICS

Structural insight into the biogenesis of β-barrel membrane proteins

(2013) Nicholas Noinaj et al.   NATURE

An archaeal origin of eukaryotes supports only two primary domains of life

(2013) Tom A. Williams et al.   NATURE

Structure ofEscherichia coliBamD and its functional implications in outer membrane protein assembly

(2012) Cheng Dong et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure ofEscherichia coliBamB and its interaction with POTRA domains of BamA

(2012) Cheng Dong et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

BB0324 and BB0028 are constituents of the Borrelia burgdorferi β-barrel assembly machine (BAM) complex

(2012) Tiffany R Lenhart et al.   BMC MICROBIOLOGY

Mitochondrial Sorting and Assembly Machinery Subunit Sam37 in Candida albicans: Insight into the Roles of Mitochondria in Fitness, Cell Wall Integrity, and Virulence

(2012) Yue Qu et al.   EUKARYOTIC CELL

Conserved Residues of the Putative L6 Loop of Escherichia coli BamA Play a Critical Role in the Assembly of  -Barrel Outer Membrane Proteins, Including That of BamA Itself

(2012) M. Leonard-Rivera et al.   JOURNAL OF BACTERIOLOGY

Chloroplast β-Barrel Proteins Are Assembled into the Mitochondrial Outer Membrane in a Process That Depends on the TOM and TOB Complexes

(2012) Thomas Ulrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane

(2012) Astrid Klein et al.   JOURNAL OF CELL BIOLOGY

Dynamic Association of BAM Complex Modules Includes Surface Exposure of the Lipoprotein BamC

(2012) Chaille T. Webb et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of BamB from Pseudomonas aeruginosa and Functional Evaluation of Its Conserved Structural Features

(2012) Katarina Bartoš Jansen et al.   PLoS One

Evolution of the β-barrel assembly machinery

(2012) Chaille T. Webb et al.   TRENDS IN MICROBIOLOGY

Crystallographic analysis of the C-terminal domain of theEscherichia colilipoprotein BamC

(2011) Kelly H. Kim et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

High-resolution structure of a new crystal form of BamA POTRA4–5 fromEscherichia coli

(2011) Heng Zhang et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Structural Characterization ofEscherichia coliBamE, a Lipoprotein Component of the β-Barrel Assembly Machinery Complex

(2011) Kelly H. Kim et al.   BIOCHEMISTRY

Eukaryote-wide sequence analysis of mitochondrial β-barrel outer membrane proteins

(2011) Kenichiro Imai et al.   BMC GENOMICS

The structural biology of β-barrel membrane proteins: a summary of recent reports

(2011) James W Fairman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure and function of BamE within the outer membrane and the β-barrel assembly machine

(2011) Timothy J Knowles et al.   EMBO REPORTS

Structural Basis of Outer Membrane Protein Biogenesis in Bacteria

(2011) Reinhard Albrecht et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of β-Barrel Assembly Machinery BamCD Protein Complex

(2011) Kelly H. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of BamD: An Essential Component of the β-Barrel Assembly Machinery of Gram-Negative Bacteria

(2011) Cristina M. Sandoval et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the BamC Two-Domain Protein Obtained by Rosetta with a Limited NMR Data Set

(2011) Lisa R. Warner et al.   JOURNAL OF MOLECULAR BIOLOGY

The Crystal Structure of BamB Suggests Interactions with BamA and Its Role within the BAM Complex

(2011) Nicholas Noinaj et al.   JOURNAL OF MOLECULAR BIOLOGY

Augmenting β-Augmentation: Structural Basis of How BamB Binds BamA and May Support Folding of Outer Membrane Proteins

(2011) Alexander Heuck et al.   JOURNAL OF MOLECULAR BIOLOGY

Biogenesis of mitochondrial β-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex

(2011) David A. Stroud et al.   MOLECULAR BIOLOGY OF THE CELL

The Neurospora crassa TOB Complex: Analysis of the Topology and Function of Tob38 and Tob37

(2011) Sebastian W. K. Lackey et al.   PLoS One

In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work

(2011) T. Shiota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and evolution of mitochondrial outer membrane proteins of β-barrel topology

(2010) Kornelius Zeth   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40

(2010) Koji Yamano et al.   EMBO REPORTS

Omp85 from the Thermophilic Cyanobacterium Thermosynechococcus elongatus Differs from Proteobacterial Omp85 in Structure and Domain Composition

(2010) Thomas Arnold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Escherichia coli BamB, a Lipoprotein Component of the β-Barrel Assembly Machinery Complex

(2010) Kelly H. Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Recognition of Mitochondrial Targeting Sequences by the Import Receptors Tom20 and Tom22

(2010) Kieran A. Rimmer et al.   JOURNAL OF MOLECULAR BIOLOGY

Assembly of the Mitochondrial Protein Import Channel

(2010) Thomas Becker et al.   MOLECULAR BIOLOGY OF THE CELL

Common ground for protein translocation: access control for mitochondria and chloroplasts

(2010) Enrico Schleiff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reconstitution of Outer Membrane Protein Assembly from Purified Components

(2010) C. L. Hagan et al.   SCIENCE

Structure and Flexibility of the Complete Periplasmic Domain of BamA: The Protein Insertion Machine of the Outer Membrane

(2010) Petia Zvezdanova Gatzeva-Topalova et al.   STRUCTURE

Biogenesis of β-barrel membrane proteins in bacteria and eukaryotes: evolutionary conservation and divergence

(2009) Dirk M. Walther et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The  -Barrel Outer Membrane Protein Assembly Complex of Neisseria meningitidis

(2009) E. B. Volokhina et al.   JOURNAL OF BACTERIOLOGY

Two Modular Forms of the Mitochondrial Sorting and Assembly Machinery Are Involved in Biogenesis of α-Helical Outer Membrane Proteins

(2009) Nicolas Thornton et al.   JOURNAL OF MOLECULAR BIOLOGY

The Mitochondrial Porin, VDAC, Has Retained the Ability to Be Assembled in the Bacterial Outer Membrane

(2009) D. M. Walther et al.   MOLECULAR BIOLOGY AND EVOLUTION

Chloroplast Proteomics and the Compartmentation of Plastidial Isoprenoid Biosynthetic Pathways

(2009) Jacques Joyard et al.   Molecular Plant

Signals in bacterial β-barrel proteins are functional in eukaryotic cells for targeting to and assembly in mitochondria

(2009) Dirk M. Walther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Sorting and assembly of mitochondrial outer membrane proteins

(2008) Thomas Becker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Biogenesis of mitochondrial outer membrane proteins

(2008) Dirk M. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Mitochondrial Proteome: From Inventory to Function

(2008) Chris Meisinger et al.   CELL

Dissecting Membrane Insertion of Mitochondrial β-Barrel Proteins

(2008) Stephan Kutik et al.   CELL

β-Barrel Proteins That Reside in theEscherichia coliOuter Membranein VivoDemonstrate Varied Folding Behaviorin Vitro

(2008) Nancy K. Burgess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tim8–Tim13 Complex Has Multiple Substrate Binding Sites and Binds Cooperatively to Tim23

(2008) Kristen N. Beverly et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Functional Requirements for Activity of the Tim9–Tim10 Complex in Mitochondrial Protein Import

(2008) Michael J. Baker et al.   MOLECULAR BIOLOGY OF THE CELL

Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes

(2008) Timothy J. Knowles et al.   MOLECULAR MICROBIOLOGY

Experimental Analysis of the Rice Mitochondrial Proteome, Its Biogenesis, and Heterogeneity

(2008) S. Huang et al.   PLANT PHYSIOLOGY

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

(2008) R. Ujwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of YaeT: Conformational Flexibility and Substrate Recognition

(2008) Petia Z. Gatzeva-Topalova et al.   STRUCTURE

The Peripheral Membrane Subunits of the SAM Complex Function Codependently in Mitochondrial Outer Membrane Biogenesis

(2007) Nickie C. Chan et al.   MOLECULAR BIOLOGY OF THE CELL