Clearance of activity‐evoked K + transients and associated glia cell swelling occur independently of AQP4 : A study with an isoform‐selective AQP4 inhibitor

Inhibitors of Mammalian Aquaporin Water Channels

(2019) Mohammed Abir-Awan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression

(2019) Brana Rosic et al.   GLIA

A single K+-binding site in the crystal structure of the gastric proton pump

(2019) Kenta Yamamoto et al.   eLife

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

(2018) Benjamin A. Plog et al.   Annual Review of Pathology-Mechanisms of Disease

Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital’s anti-seizure efficacy

(2018) Claudia Brandt et al.   NEUROPHARMACOLOGY

Developmental maturation of activity-induced K+ and pH transients and the associated extracellular space dynamics in the rat hippocampus

(2018) Brian Roland Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

The aquaporin-4 water channel as a potential drug target in neurological disorders

(2017) Alan S. Verkman et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model

(2017) Cordula Rakers et al.   GLIA

The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation

(2017) Anca Stoica et al.   GLIA

Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms

(2017) Brian Roland Larsen et al.   GLIA

Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways

(2017) Ionica Pirici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor

(2017) Trine L. Toft-Bertelsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glutamate transporter activity promotes enhanced Na+/K+-ATPase-mediated extracellular K+management during neuronal activity

(2016) Brian Roland Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

High effective cytosolic H+buffering in mouse cortical astrocytes attributable to fast bicarbonate transport

(2015) Shefeeq M. Theparambil et al.   GLIA

Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes

(2015) Shefeeq M. Theparambil et al.   JOURNAL OF PHYSIOLOGY-LONDON

Principles and standards for reporting animal experiments inThe Journal of PhysiologyandExperimental Physiology

(2015) David Grundy   JOURNAL OF PHYSIOLOGY-LONDON

Deletion of aquaporin-4 increases extracellular K+ concentration during synaptic stimulation in mouse hippocampus

(2014) Nadia Nabil Haj-Yasein et al.   Brain Structure & Function

Kir4.1-mediated spatial buffering of K+: Experimental challenges in determination of its temporal and quantitative contribution to K+clearance in the brain

(2014) Brian Roland Larsen et al.   Channels

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

The Electrogenic Sodium Bicarbonate Cotransporter NBCe1 Is a High-Affinity Bicarbonate Carrier in Cortical Astrocytes

(2014) S. M. Theparambil et al.   JOURNAL OF NEUROSCIENCE

Astrocyte glycogen as an emergency fuel under conditions of glucose deprivation or intense neural activity

(2014) Angus M. Brown et al.   METABOLIC BRAIN DISEASE

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: A gene deletion study in mouse hippocampus

(2012) Nadia Nabil Haj-Yasein et al.   GLIA

Aquaporin-4–dependent K+and water transport modeled in brain extracellular space following neuroexcitation

(2012) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Aquaporins in drug discovery and pharmacotherapy

(2012) Vincent J. Huber et al.   MOLECULAR ASPECTS OF MEDICINE

Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase

(2012) Hyun B. Choi et al.   NEURON

Dynamic Volume Changes in Astrocytes Are an Intrinsic Phenomenon Mediated by Bicarbonate Ion Flux

(2012) Clare M. Florence et al.   PLoS One

Development of a Novel Ligand, [11C]TGN-020, for Aquaporin 4 Positron Emission Tomography Imaging

(2011) Yukihiro Nakamura et al.   ACS Chemical Neuroscience

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human kir4.1 gene (KCNJ10)

(2011) Nadia Nabil Haj-Yasein et al.   GLIA

Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampus

(2011) Susan Strohschein et al.   GLIA

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implication of Kir4.1 Channel in Excess Potassium Clearance: An In Vivo Study on Anesthetized Glial-Conditional Kir4.1 Knock-Out Mice

(2010) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

(2010) Hironaka Igarashi et al.   NEUROLOGICAL SCIENCES

Differential water permeability and regulation of three aquaporin 4 isoforms

(2009) Robert A. Fenton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanism of Aquaporin-4's Fast and Highly Selective Water Conduction and Proton Exclusion

(2009) Kazutoshi Tani et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of Aquaporin-1 and Aquaporin-4 Water Permeability by a Derivative of the Loop Diuretic Bumetanide Acting at an Internal Pore-Occluding Binding Site

(2009) E. Migliati et al.   MOLECULAR PHARMACOLOGY

Water transport between CNS compartments: contributions of aquaporins and cotransporters

(2009) N. MacAulay et al.   NEUROSCIENCE

Inhibition of Aquaporin 4 by antiepileptic drugs

(2008) Vincent J. Huber et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of Aquaporin 4 inhibitors using in vitro and in silico methods

(2008) Vincent J. Huber et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity

(2008) Anne B. Walls et al.   JOURNAL OF NEUROCHEMISTRY

Aquaporin-4-Deficient Mice Have Increased Extracellular Space without Tortuosity Change

(2008) X. Yao et al.   JOURNAL OF NEUROSCIENCE

Acetazolamide reversibly inhibits water conduction by aquaporin-4

(2008) Yukihiro Tanimura et al.   JOURNAL OF STRUCTURAL BIOLOGY