The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

Spreading depolarizations in patients with spontaneous intracerebral hemorrhage: Association with perihematomal edema progression

(2016) Raimund Helbok et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

(2016) Jens P Dreier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Excitotoxicity and Metabolic Crisis Are Associated with Spreading Depolarizations in Severe Traumatic Brain Injury Patients

(2016) Jason M. Hinzman et al.   JOURNAL OF NEUROTRAUMA

Professor Leão’s original note

(2015) Péricles Maranhão Filho   ARQUIVOS DE NEURO-PSIQUIATRIA

Dynamics of Ionic Shifts in Cortical Spreading Depression

(2015) Rune Enger et al.   CEREBRAL CORTEX

Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions

(2015) Jason M. Hinzman et al.   EXPERIMENTAL NEUROLOGY

Imaging of acute stroke: CT and/or MRI

(2015) Karl-Olof Lövblad et al.   JOURNAL OF NEURORADIOLOGY

Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading

(2015) A. B. Steffensen et al.   JOURNAL OF NEUROSCIENCE

Supply-Demand Mismatch Transients in Susceptible Peri-infarct Hot Zones Explain the Origins of Spreading Injury Depolarizations

(2015) Daniel von Bornstädt et al.   NEURON

The Stroke-Migraine Depolarization Continuum

(2015) Jens P. Dreier et al.   NEURON

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

(2015) Cenk Ayata et al.   PHYSIOLOGICAL REVIEWS

Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma

(2014) Jason M. Hinzman et al.   BRAIN

Spreading Depolarization May Link Migraine and Stroke

(2014) Katharina Eikermann-Haerter   HEADACHE

Imaging Reveals the Focal Area of Spreading Depolarizations and a Variety of Hemodynamic Responses in a Rat Microembolic Stroke Model

(2014) Zsófia Bere et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Detecting Tissue Deterioration after Brain Injury: Regional Blood Flow Level versus Capacity to Raise Blood Flow

(2014) Delphine Feuerstein et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Minimum conditions for the induction of cortical spreading depression in brain slices

(2014) Yujie T. Tang et al.   JOURNAL OF NEUROPHYSIOLOGY

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

Dynamic perfusion and diffusion MRI of cortical spreading depolarization in photothrombotic ischemia

(2014) Yu-Chieh Jill Kao et al.   NEUROBIOLOGY OF DISEASE

Clusters of Cortical Spreading Depolarizations in a Patient with Intracerebral Hemorrhage: A Multimodal Neuromonitoring Study

(2014) A. J. Schiefecker et al.   Neurocritical Care

Real-Time Optical Diagnosis of the Rat Brain Exposed to a Laser-Induced Shock Wave: Observation of Spreading Depolarization, Vasoconstriction and Hypoxemia-Oligemia

(2014) Shunichi Sato et al.   PLoS One

Brainstem Neurons Survive the Identical Ischemic Stress That Kills Higher Neurons: Insight to the Persistent Vegetative State

(2014) C. Devin Brisson et al.   PLoS One

Evolution of neuronal and astroglial disruption in the peri-contusional cortex of mice revealed by in vivo two-photon imaging

(2013) Jeremy Sword et al.   BRAIN

Regenerative Glutamate Release by Presynaptic NMDA Receptors Contributes to Spreading Depression

(2013) Ning Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Surgical management of traumatic brain injury: a comparative-effectiveness study of 2 centers

(2013) Jed A. Hartings et al.   JOURNAL OF NEUROSURGERY

Propagation of cortical spreading depolarization in the human cortex after malignant stroke

(2013) J. Woitzik et al.   NEUROLOGY

Ischemia-induced depolarizations and associated hemodynamic responses in incomplete global forebrain ischemia in rats

(2013) Z. Bere et al.   NEUROSCIENCE

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Spreading depression and the clinical correlates of migraine

(2013) Katharina Eikermann-Haerter et al.   REVIEWS IN THE NEUROSCIENCES

Spreading Depression and Neurovascular Coupling

(2013) C. Ayata   STROKE

Electrochemical Failure of the Brain Cortex Is More Deleterious When it Is Accompanied by Low Perfusion

(2013) Jens P. Dreier et al.   STROKE

Persistent astroglial swelling accompanies rapid reversible dendritic injury during stroke-induced spreading depolarizations

(2012) W. Christopher Risher et al.   GLIA

Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model

(2012) Shoji Yokobori et al.   JOURNAL OF NEUROSURGERY

Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons

(2012) Isamu Aiba et al.   JOURNAL OF PHYSIOLOGY-LONDON

Is Spreading Depolarization Characterized by an Abrupt, Massive Release of Gibbs Free Energy from the Human Brain Cortex?

(2012) Jens P. Dreier et al.   NEUROSCIENTIST

Clusters of Spreading Depolarizations Are Associated With Disturbed Cerebral Metabolism in Patients With Aneurysmal Subarachnoid Hemorrhage

(2012) Oliver W. Sakowitz et al.   STROKE

Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex

(2011) J. P. Dreier et al.   BRAIN

Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma

(2011) Jed A. Hartings et al.   BRAIN

Metabolic and Perfusion Responses to Recurrent Peri-Infarct Depolarization during Focal Ischemia in the Spontaneously Hypertensive Rat: Dominant Contribution of Sporadic CBF Decrements to Infarct Expansion

(2011) Yoshimasa Takeda et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

(2011) Jed A Hartings et al.   LANCET NEUROLOGY

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression

(2010) Joshua C. Chang et al.   BRAIN

Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions

(2010) Hajime Nakamura et al.   BRAIN

Calcium, ischemia and excitotoxicity

(2010) Kinga Szydlowska et al.   CELL CALCIUM

An update on the blood vessel in migraine

(2010) KC Brennan et al.   CURRENT OPINION IN NEUROLOGY

Distinct Spatiotemporal Patterns of Spreading Depolarizations during Early Infarct Evolution: Evidence from Real-Time Imaging

(2010) Tetsuya Kumagai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dynamic Metabolic Response to Multiple Spreading Depolarizations in Patients with Acute Brain Injury: An Online Microdialysis Study

(2010) Delphine Feuerstein et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

(2010) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Changes in Membrane Potential and the Intracellular Calcium Concentration During CSD and OGD in Layer V and Layer II/III Mouse Cortical Neurons

(2010) Helen M. Gniel et al.   JOURNAL OF NEUROPHYSIOLOGY

Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

(2010) W. C. Risher et al.   JOURNAL OF NEUROSCIENCE

Acute Ischemic Injury on Diffusion-Weighted Magnetic Resonance Imaging after Poor Grade Subarachnoid Hemorrhage

(2010) Katja E. Wartenberg et al.   Neurocritical Care

Multi-modal imaging of anoxic depolarization and hemodynamic changes induced by cardiac arrest in the rat cerebral cortex

(2010) Eszter Farkas et al.   NEUROIMAGE

Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke

(2010) M. D. Budde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microemboli may link spreading depression, migraine aura, and patent foramen ovale

(2009) Ala Nozari et al.   ANNALS OF NEUROLOGY

Recurrent spreading depolarizations after subarachnoid hemorrhage decreases oxygen availability in human cerebral cortex

(2009) Bert Bosche et al.   ANNALS OF NEUROLOGY

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

(2009) J. P. Dreier et al.   BRAIN

Preconditioning paradigms and pathways in the brain.

(2009) K. B Shpargel et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Persistent Increase in Oxygen Consumption and Impaired Neurovascular Coupling after Spreading Depression in Rat Neocortex

(2009) Henning Piilgaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Contributions of Ca2+and Zn2+to spreading depression-like events and neuronal injury

(2009) Robert M. Dietz et al.   JOURNAL OF NEUROCHEMISTRY

Spreading Depolarizations and Late Secondary Insults after Traumatic Brain Injury

(2009) Jed A. Hartings et al.   JOURNAL OF NEUROTRAUMA

Spreading depolarizations occur in human ischemic stroke with high incidence

(2008) Christian Dohmen et al.   ANNALS OF NEUROLOGY

Metabolic Challenge to Glia Activates an Adenosine-Mediated Safety Mechanism that Promotes Neuronal Survival by Delaying the Onset of Spreading Depression Waves

(2008) Santiago Canals et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of Cortical Spreading Depressions for Secondary Brain Damage after Traumatic Brain Injury in Mice

(2008) Louisa von Baumgarten et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Persisting Depletion of Brain Glucose following Cortical Spreading Depression, despite Apparent Hyperaemia: Evidence for Risk of an Adverse Effect of Leão's Spreading Depression

(2008) Parastoo Hashemi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Two-Photon Imaging of Stroke Onset In Vivo Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines

(2008) T. H. Murphy et al.   JOURNAL OF NEUROSCIENCE

Zn2+ Influx Is Critical for Some Forms of Spreading Depression in Brain Slices

(2008) R. M. Dietz et al.   JOURNAL OF NEUROSCIENCE

Characterization of periinfarct flow transients with laser speckle and Doppler after middle cerebral artery occlusion in the rat

(2008) Janos Luckl et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Repetitive cortical spreading depolarizations in a case of severe brain trauma

(2008) Jed A. Hartings et al.   NEUROLOGICAL RESEARCH

Induction of Neurogenesis in the Adult Dentate Gyrus by Cortical Spreading Depression

(2008) Anja Urbach et al.   STROKE