Pathogenesis of Brain Edema and Investigation into Anti-Edema Drugs

The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies

(2014) Elke Kooijman et al.   Journal of Neuroinflammation

Brain edema in acute liver failure: mechanisms and concepts

(2014) Kakulavarapu V. Rama Rao et al.   METABOLIC BRAIN DISEASE

The brain in acute on chronic liver failure

(2014) Gavin Wright et al.   METABOLIC BRAIN DISEASE

Glibenclamide reduces secondary brain damage after experimental traumatic brain injury

(2014) K. Zweckberger et al.   NEUROSCIENCE

Vascular Endothelial Growth Factors Enhance the Permeability of the Mouse Blood-brain Barrier

(2014) Shize Jiang et al.   PLoS One

Amelioration of Cold Injury-Induced Cortical Brain Edema Formation by Selective Endothelin ETB Receptor Antagonists in Mice

(2014) Shotaro Michinaga et al.   PLoS One

Drowning stars: reassessing the role of astrocytes in brain edema

(2014) Alexander S. Thrane et al.   TRENDS IN NEUROSCIENCES

Sulfonylurea Receptor 1 Contributes to the Astrocyte Swelling and Brain Edema in Acute Liver Failure

(2014) A. R. Jayakumar et al.   Translational Stroke Research

Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study

(2013) Ryu Matsuo et al.   BMC Neurology

Advances in the management of intracerebral hemorrhage

(2013) J. B. Kuramatsu et al.   JOURNAL OF NEURAL TRANSMISSION

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

Magnetic resonance of the brain in chronic and acute liver failure

(2013) Laia Chavarria et al.   METABOLIC BRAIN DISEASE

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure

(2013) Kakulavarapu V. Rama Rao et al.   NEUROBIOLOGY OF DISEASE

Brain edema in acute liver failure and chronic liver disease: Similarities and differences

(2013) Cristina R. Bosoi et al.   NEUROCHEMISTRY INTERNATIONAL

Glibenclamide in Cerebral Ischemia and Stroke

(2013) J. Marc Simard et al.   Neurocritical Care

Glyburide is Associated with Attenuated Vasogenic Edema in Stroke Patients

(2013) W. Taylor Kimberly et al.   Neurocritical Care

Delayed Progression of Edema Formation Around a Hematoma Expressing High Levels of VEGF and MMP-9 in a Patient With Traumatic Brain Injury: Case Report

(2013) Tomoya HIROSE et al.   NEUROLOGIA MEDICO-CHIRURGICA

Status Epilepticus Induces Vasogenic Edema via Tumor Necrosis Factor-α/ Endothelin-1-Mediated Two Different Pathways

(2013) Ji-Eun Kim et al.   PLoS One

Aquaporin-4 Inhibition Mediates Piroxicam-Induced Neuroprotection against Focal Cerebral Ischemia/Reperfusion Injury in Rodents

(2013) Pallab Bhattacharya et al.   PLoS One

Pathophysiology of cerebral oedema in acute liver failure

(2013) Teresa R Scott   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular mechanisms of cognitive dysfunction following traumatic brain injury

(2013) Kendall R. Walker et al.   Frontiers in Aging Neuroscience

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies

(2012) Gang Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neurovascular Matrix Metalloproteinases and the Blood-Brain Barrier

(2012) Ji Hae Seo et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting endothelin receptors for pharmacotherapy of ischemic stroke: current scenario and future perspectives

(2012) Ravinder K. Kaundal et al.   DRUG DISCOVERY TODAY

Endothelins reciprocally regulate VEGF-A and angiopoietin-1 production in cultured rat astrocytes: Implications on astrocytic proliferation

(2012) Yutaka Koyama et al.   GLIA

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Aquaporin 4: a player in cerebral edema and neuroinflammation

(2012) Andrew M Fukuda et al.   Journal of Neuroinflammation

Blood–brain barrier permeability is positively correlated with cerebral microvascular perfusion in the early fluid percussion-injured brain of the rat

(2012) Yong Lin et al.   LABORATORY INVESTIGATION

Glutamine in the pathogenesis of acute hepatic encephalopathy

(2012) Kakulavarapu V. Rama Rao et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotection afforded by antagonists of endothelin-1 receptors in experimental stroke

(2012) Octavio Moldes et al.   NEUROPHARMACOLOGY

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

(2012) Donald E. Kimbler et al.   PLoS One

Glibenclamide—10-h Treatment Window in a Clinically Relevant Model of Stroke

(2012) J. Marc Simard et al.   Translational Stroke Research

The Molecular Mechanisms that Promote Edema After Intracerebral Hemorrhage

(2012) Daniel Bodmer et al.   Translational Stroke Research

Brain Water Content: a Misunderstood Measurement?

(2012) Richard F. Keep et al.   Translational Stroke Research

Dexamethasone inhibits ICAM-1 and MMP-9 expression and reduces brain edema in intracerebral hemorrhagic rats

(2011) Jen-Tsung Yang et al.   ACTA NEUROCHIRURGICA

Experimental Intracerebral Hemorrhage: Avoiding Pitfalls in Translational Research

(2011) Matthew A Kirkman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neurological complications of acute liver failure: Pathophysiological basis of current management and emerging therapies

(2011) Liliane Mpabanzi et al.   NEUROCHEMISTRY INTERNATIONAL

I.c.v administration of an endothelin ETB receptor agonist stimulates vascular endothelial growth factor-A production and activates vascular endothelial growth factor receptors in rat brain

(2011) Y. Koyama et al.   NEUROSCIENCE

Novel Treatment Targets for Cerebral Edema

(2011) Brian P. Walcott et al.   Neurotherapeutics

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

(2011) Janet Alder et al.   Jove-Journal of Visualized Experiments

Brain Edema in Acute Liver Failure

(2010) Kakulavarapu V. Rama Rao et al.   AMERICAN JOURNAL OF PATHOLOGY

Vascular endothelial growth factors and vascular permeability

(2010) D. O. Bates   CARDIOVASCULAR RESEARCH

Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments

(2010) James J Donkin et al.   CURRENT OPINION IN NEUROLOGY

Treatment of Brain Edema in Acute Liver Failure

(2010) Alejandro A. Rabinstein   Current Treatment Options in Neurology

Effects of Aquaporin-4 on edema formation following intracerebral hemorrhage

(2010) Yuping Tang et al.   EXPERIMENTAL NEUROLOGY

Chemical preconditioning-induced reactive astrocytosis contributes to the reduction of post-ischemic edema through aquaporin-4 downregulation

(2010) Akihiko Hoshi et al.   EXPERIMENTAL NEUROLOGY

Brain Region-Selective Mechanisms Contribute to the Progression of Cerebral Alterations in Acute Liver Failure in Rats

(2010) Omar Cauli et al.   GASTROENTEROLOGY

Inhibition of Bradykinin Receptor B1 Protects Mice from Focal Brain Injury by Reducing Blood–Brain Barrier Leakage and Inflammation

(2010) Furat Raslan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Na–K–Cl cotransporter in the brain edema of acute liver failure

(2010) Arumugam R. Jayakumar et al.   JOURNAL OF HEPATOLOGY

Brain Aquaporin-4 in Experimental Acute Liver Failure

(2010) Kakulavarapu V. Rama Rao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Matrix Metalloproteinase-9 Expression and Protein Levels after Fluid Percussion Injury in Rats: The Effect of Injury Severity and Brain Temperature

(2010) Feng Jia et al.   JOURNAL OF NEUROTRAUMA

Intracerebroventricular Administration of an Endothelin ETB–Receptor Agonist Increases Expression of Matrix Metalloproteinase-2 and -9 in Rat Brain

(2010) Yutaka Koyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Exploring Neuroprotective Drug Therapies for Intracerebral Hemorrhage

(2010) Hiroshi Katsuki   JOURNAL OF PHARMACOLOGICAL SCIENCES

Prevention and management of brain edema in patients with acute liver failure

(2010) Fin Stolze Larsen et al.   LIVER TRANSPLANTATION

The Na–K–Cl Co-transporter in astrocyte swelling

(2010) Arumugam R. Jayakumar et al.   METABOLIC BRAIN DISEASE

NF-κB in the mechanism of brain edema in acute liver failure: Studies in transgenic mice

(2010) A.R. Jayakumar et al.   NEUROBIOLOGY OF DISEASE

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

(2010) Hironaka Igarashi et al.   NEUROLOGICAL SCIENCES

Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury

(2010) S. Nag et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pathology and new players in the pathogenesis of brain edema

(2009) Sukriti Nag et al.   ACTA NEUROPATHOLOGICA

NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascade

(2009) Kwok-Tung Lu et al.   CRITICAL CARE MEDICINE

Targeted Overexpression of Endothelin-1 in Astrocytes Leads to More Severe Cytotoxic Brain Edema and Higher Mortality

(2009) Patrick Ka Kit Yeung et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury

(2009) Paula Pifarré et al.   JOURNAL OF NEUROCHEMISTRY

Molecular mechanisms of microvascular failure in central nervous system injury—synergistic roles of NKCC1 and SUR1/TRPM4

(2009) J. Marc Simard et al.   JOURNAL OF NEUROSURGERY

Key Role of Sulfonylurea Receptor 1 in Progressive Secondary Hemorrhage after Brain Contusion

(2009) J. Marc Simard et al.   JOURNAL OF NEUROTRAUMA

Injury-Related Production of Cysteinyl Leukotrienes Contributes to Brain Damage following Experimental Traumatic Brain Injury

(2009) Santiago Farias et al.   JOURNAL OF NEUROTRAUMA

Alterations in Blood-Brain Barrier Permeability to Large and Small Molecules and Leukocyte Accumulation after Traumatic Brain Injury: Effects of Post-Traumatic Hypothermia

(2009) George Lotocki et al.   JOURNAL OF NEUROTRAUMA

Vascular Endothelial Growth Factor Is Involved in Mediating Increased De Novo Hippocampal Neurogenesis in Response to Traumatic Brain Injury

(2009) Cheol Lee et al.   JOURNAL OF NEUROTRAUMA

Intracerebral haemorrhage

(2009) Adnan I Qureshi et al.   LANCET

ELEVATION OF MATRIX METALLOPROTEINASES 3 AND 9 IN CEREBROSPINAL FLUID AND BLOOD IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY

(2009) Mark Grossetete et al.   NEUROSURGERY

Molecular Mechanisms of Ischemic Cerebral Edema: Role of Electroneutral Ion Transport

(2009) Kristopher T. Kahle et al.   PHYSIOLOGY

Endothelin-1 as a neuropeptide: neurotransmitter or neurovascular effects?

(2009) Michael R. Dashwood et al.   Journal of Cell Communication and Signaling

Dexamethasone coordinately regulates angiopoietin-1 and VEGF: A mechanism of glucocorticoid-induced stabilization of blood–brain barrier

(2008) Hyongbum Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Brain endothelial cells and the glio-vascular complex

(2008) Hartwig Wolburg et al.   CELL AND TISSUE RESEARCH

Glial Cell Aquaporin-4 Overexpression in Transgenic Mice Accelerates Cytotoxic Brain Swelling

(2008) Baoxue Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Na-K-Cl Cotransporter-1 in the Mechanism of Ammonia-induced Astrocyte Swelling

(2008) Arumugam R. Jayakumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Analysis of Regional Microvascular Loss and Recovery following Two Grades of Fluid Percussion Trauma: A Role for Hypoxia-Inducible Factors in Traumatic Brain Injury

(2008) Eugene Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain edema after intracerebral hemorrhage in rats: the role of iron overload and aquaporin 4

(2008) Wang Gai Qing et al.   JOURNAL OF NEUROSURGERY

Encephalopathy and Cerebral Edema in the Setting of Acute Liver Failure: Pathogenesis and Management

(2008) Julia Wendon et al.   Neurocritical Care