The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease

Na+/K+ ATPase Inhibitors in Cancer

(2018) Konstantinos Alevizopoulos   CURRENT DRUG TARGETS

Time- and dose dependent actions of cardiotonic steroids on transcriptome and intracellular content of Na+ and K+: a comparative analysis

(2017) Elizaveta A. Klimanova et al.   Scientific Reports

Na+-K+-ATPase, a new class of plasma membrane receptors

(2016) Anita Aperia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A case of rapid-onset dystonia-parkinsonism accompanied by pyramidal tract impairment

(2016) Yanqiu Liu et al.   BMC Neurology

De novo p.Arg756Cys mutation of ATP1A3 causes an atypical form of alternating hemiplegia of childhood with prolonged paralysis and choreoathetosis

(2016) Hikaru Kanemasa et al.   BMC Neurology

Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation

(2016) N Pelzer et al.   CEPHALALGIA

Defective glutamate and K+clearance by cortical astrocytes in familial hemiplegic migraine type 2

(2016) Clizia Capuani et al.   EMBO Molecular Medicine

Selective Assembly of Na,K-ATPase α2β2Heterodimers in the Heart

(2016) Michael Habeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct α2 Na,K-ATPase membrane pools are differently involved in early skeletal muscle remodeling during disuse

(2016) Violetta V. Kravtsova et al.   JOURNAL OF GENERAL PHYSIOLOGY

ATP1A3 Mutation in Adult Rapid-Onset Ataxia

(2016) Kathleen J. Sweadner et al.   PLoS One

Digoxin: The good and the bad

(2016) Oliver J. Ziff et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Tuning of the Na,K-ATPase by the beta subunit

(2016) Florian Hilbers et al.   Scientific Reports

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model

(2016) Pernille Bøttger et al.   Scientific Reports

Beneficial Renal and Pancreatic Phenotypes in a Mouse Deficient in FXYD2 Regulatory Subunit of Na,K-ATPase

(2016) Elena Arystarkhova   Frontiers in Physiology

Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases

(2016) Marc Baker Bechmann et al.   Frontiers in Physiology

Sodium pump organization in dendritic spines

(2016) Hans Blom et al.   Neurophotonics

Aberrant association of misfolded SOD1 with Na+/K+ATPase-α3 impairs its activity and contributes to motor neuron vulnerability in ALS

(2015) Céline Ruegsegger et al.   ACTA NEUROPATHOLOGICA

Membrane accessibility of glutathione

(2015) Alvaro Garcia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Importance of the Voltage Dependence of Cardiac Na/K ATPase Isozymes

(2015) Christopher M. Stanley et al.   BIOPHYSICAL JOURNAL

Targeting Na+/K+-translocating adenosine triphosphatase in cancer treatment

(2015) Cameron T. Durlacher et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype

(2015) Ute I. Scholl et al.   CLINICAL ENDOCRINOLOGY

 -synuclein assemblies sequester neuronal  3-Na+/K+-ATPase and impair Na+ gradient

(2015) A. N. Shrivastava et al.   EMBO JOURNAL

Pathogenesis of Adrenal Aldosterone-Producing Adenomas Carrying Mutations of the Na+/K+-ATPase

(2015) J. Stindl et al.   ENDOCRINOLOGY

Novel mutations inATP1A3associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly

(2015) Alex R. Paciorkowski et al.   EPILEPSIA

The α4 isoform of the Na+,K+-ATPase is tuned for changing extracellular environments

(2015) Michael Voldsgaard Clausen et al.   FEBS Journal

Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase

(2015) Neeraj Kumar Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CAOS—Episodic Cerebellar Ataxia, Areflexia, Optic Atrophy, and Sensorineural Hearing Loss

(2015) Gali Heimer et al.   JOURNAL OF CHILD NEUROLOGY

Role of human Na,K-ATPase alpha 4 in sperm function, derived from studies in transgenic mice

(2015) Jeffrey McDermott et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

A functional correlate of severity in alternating hemiplegia of childhood

(2015) Melody Li et al.   NEUROBIOLOGY OF DISEASE

Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations

(2015) Ada E.D. Teo et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Expanding Spectrum of Neurological Phenotypes in Children With ATP1A3 Mutations, Alternating Hemiplegia of Childhood, Rapid-onset Dystonia-Parkinsonism, CAPOS and Beyond

(2015) Matthew T. Sweney et al.   PEDIATRIC NEUROLOGY

Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

(2015) Mette Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands

(2015) Koshiro Nishimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread convergence in toxin resistance by predictable molecular evolution

(2015) Beata Ujvari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

(2015) Takayuki Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pumps that fuel a sperm's journey

(2015) Michael Jakob Clausen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Localization of Na+–K+-ATPase α/β, Na+–K+–2Cl-cotransporter 1 and aquaporin-5 in human eccrine sweat glands

(2014) Mingjun Zhang et al.   ACTA HISTOCHEMICA

Molecular Mechanism of Na+,K+-ATPase Malfunction in Mutations Characteristic of Adrenal Hypertension

(2014) Wojciech Kopec et al.   BIOCHEMISTRY

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

Distinct neurological disorders with ATP1A3 mutations

(2014) Erin L Heinzen et al.   LANCET NEUROLOGY

Phenotypic overlap of alternating hemiplegia of childhood and CAPOS syndrome

(2014) H. Rosewich et al.   NEUROLOGY

A novel recurrent mutation in ATP1A3 causes CAPOS syndrome

(2014) Michelle K Demos et al.   Orphanet Journal of Rare Diseases

Knockout of the Na,K-ATPase α2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction

(2013) Tara N. Rindler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hyperplasia of Pancreatic Beta Cells and Improved Glucose Tolerance in Mice Deficient in the FXYD2 Subunit of Na,K-ATPase

(2013) Elena Arystarkhova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state

(2013) Ryuta Kanai et al.   NATURE

The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm

(2013) Anne-Marie L. Winther et al.   NATURE

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

(2013) Elena A B Azizan et al.   NATURE GENETICS

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

(2013) Felix Beuschlein et al.   NATURE GENETICS

Molecular Cloning and Characterization of Porcine Na+/K+-ATPase Isoforms α1, α2, α3 and the ATP1A3 Promoter

(2013) Carina Henriksen et al.   PLoS One

Crystal Structure of Na + , K + -ATPase in the Na + -Bound State

(2013) Maria Nyblom et al.   SCIENCE

Activity of the Na,K-ATPase  4 Isoform Is Regulated During Sperm Capacitation to Support Sperm Motility

(2012) T. Jimenez et al.   JOURNAL OF ANDROLOGY

Green fluorescence protein driven by the Na,K-ATPase α4 isoform promoter is expressed only in male germ cells of mouse testis

(2012) Jeffrey P. McDermott et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Subunit Isoform Selectivity in Assembly of Na,K-ATPase α-β Heterodimers

(2012) Elmira Tokhtaeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Specific and Essential Role for Na,K-ATPase α3 in Neurons Co-expressing α1 and α3

(2012) Guillaume Azarias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study

(2012) Hendrik Rosewich et al.   LANCET NEUROLOGY

De novo mutations in ATP1A3 cause alternating hemiplegia of childhood

(2012) Erin L Heinzen et al.   NATURE GENETICS

Psychiatric disorders in rapid-onset dystonia-parkinsonism

(2012) A. Brashear et al.   NEUROLOGY

Origin of first cells at terrestrial, anoxic geothermal fields

(2012) A. Y. Mulkidjanian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parallel Molecular Evolution in an Herbivore Community

(2012) Y. Zhen et al.   SCIENCE

Bufadienolides and their antitumor activity

(2011) Huimin Gao et al.   NATURAL PRODUCT REPORTS

Migraine- and dystonia-related disease-mutations of Na+/K+-ATPases: Relevance of behavioral studies in mice to disease symptoms and neurological manifestations in humans

(2011) Pernille Bøttger et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

(2011) M. Choi et al.   SCIENCE

N-Glycan-Dependent Quality Control of the Na,K-ATPase β2Subunit

(2010) Elmira Tokhtaeva et al.   BIOCHEMISTRY

Increased Expression of the Na,K-ATPase alpha4 Isoform Enhances Sperm Motility in Transgenic Mice1

(2010) Tamara Jimenez et al.   BIOLOGY OF REPRODUCTION

Review Article: Phospholemman: A Novel Cardiac Stress Protein

(2010) Joseph Y. Cheung et al.   CTS-Clinical and Translational Science

The Retinal Pigment Epithelium in Health and Disease

(2010) J. R. Sparrrow et al.   CURRENT MOLECULAR MEDICINE

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

(2010) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain

(2010) Pernille Bøttger et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts

(2010) Nathalie Gaborit et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sperm Proteomics Reveals Intensified Selection on Mouse Sperm Membrane and Acrosome Genes

(2010) Steve Dorus et al.   MOLECULAR BIOLOGY AND EVOLUTION

Neurological disease mutations compromise a C-terminal ion pathway in the Na+/K+-ATPase

(2010) Hanne Poulsen et al.   NATURE

Na,K-ATPase  4 isoform is essential for sperm fertility

(2010) T. Jimenez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and Distribution of Na, K-ATPase Isoforms in the Human Uterus

(2010) Rachel V. Floyd et al.   Reproductive Sciences

Palytoxin action on the Na+,K+-ATPase and the disruption of ion equilibria in biological systems

(2010) Gian Paolo Rossini et al.   TOXICON

Reversible Oxidative Modification: Implications for Cardiovascular Physiology and Pathophysiology

(2010) Helge H. Rasmussen et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase β1-subunit

(2009) Sonali P. Barwe et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Crystal structure of the sodium–potassium pump at 2.4 Å resolution

(2009) Takehiro Shinoda et al.   NATURE

Distribution of the Na,K-ATPase α Subunit in the Rat Spiral Ganglion and Organ of Corti

(2008) Will J. McLean et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Elevated testicular temperature modulates expression patterns of sperm proteins in Holstein bulls

(2008) L.D. Newton et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations

(2008) J. P. Morth et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity

(2007) James R. Bell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY