Fibroblast pathology in inflammatory joint disease

LncRNA NEAT1 regulates the proliferation and production of the inflammatory cytokines in rheumatoid arthritis fibroblast-like synoviocytes by targeting miR-204-5p

(2021) Jianwei Xiao et al.   Human Cell

Mapping the musculoskeletal system one cell at a time

(2021) Mathew J. Baldwin et al.   Nature Reviews Rheumatology

Location, location, location: how the tissue microenvironment affects inflammation in RA

(2021) Christopher D. Buckley et al.   Nature Reviews Rheumatology

MicroRNA‑23a‑5p regulates cell proliferation, migration and inflammation of TNF‑α‑stimulated human fibroblast‑like MH7A synoviocytes by targeting TLR4 in rheumatoid arthritis

(2021) Xiao Bao et al.   Experimental and Therapeutic Medicine

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

(2021) Jasna Friščić et al.   IMMUNITY

Origin and functional heterogeneity of fibroblasts

(2020) Valerie S. LeBleu et al.   FASEB JOURNAL

Single-cell genomic approaches for developing the next generation of immunotherapies

(2020) Ido Yofe et al.   NATURE MEDICINE

Involvement of long non-coding RNAs in the pathogenesis of rheumatoid arthritis

(2020) Min-Xi Lao et al.   CHINESE MEDICAL JOURNAL

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

(2020) Gyrid Nygaard et al.   Nature Reviews Rheumatology

Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis

(2020) Xuezhi Yang et al.   CELL PROLIFERATION

The mesenchymal context in inflammation, immunity and cancer

(2020) Vasiliki Koliaraki et al.   NATURE IMMUNOLOGY

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

(2020) Stefano Alivernini et al.   NATURE MEDICINE

RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares

(2020) Dana E. Orange et al.   NEW ENGLAND JOURNAL OF MEDICINE

Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4

(2020) Yoshihide Ichise et al.   Cells

Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: First report of FAPME, a phase I clinical trial

(2020) S. Hiltbrunner et al.   ANNALS OF ONCOLOGY

CADM1 enhances intestinal barrier function in a rat model of mild inflammatory bowel disease by inhibiting the STAT3 signaling pathway

(2020) Shengtao Sun et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-κB axis

(2020) Jinghan Yang et al.   Cell Death & Disease

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

(2020) Georg Schett et al.   Nature Reviews Rheumatology

Chimeric Antigen Receptor Based Therapy as a Potential Approach in Autoimmune Diseases: How Close Are We to the Treatment?

(2020) Muhammad Sadeqi Nezhad et al.   Frontiers in Immunology

Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity

(2019) Santiago P. Mendez-Huergo et al.   Frontiers in Immunology

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

(2019) Frances Humby et al.   ANNALS OF THE RHEUMATIC DISEASES

TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis

(2019) Christopher Loh et al.   ANNALS OF THE RHEUMATIC DISEASES

RGS1 silencing inhibits the inflammatory response and angiogenesis in rheumatoid arthritis rats through the inactivation of Toll‐like receptor signaling pathway

(2019) Xumin Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness

(2019) David Kuo et al.   Science Translational Medicine

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

(2019) Matthew B. Buechler et al.   IMMUNITY

Clinical promise of next-generation complement therapeutics

(2019) Dimitrios C. Mastellos et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes

(2019) Hiroyuki Yoshitomi   Frontiers in Immunology

Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis

(2019) Marina V. Nemtsova et al.   Frontiers in Genetics

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

(2019) Myles J. Lewis et al.   Cell Reports

DNA Methylation as a Future Therapeutic and Diagnostic Target in Rheumatoid Arthritis

(2019) Marzena Ciechomska et al.   Cells

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019

(2019) Kevin L Winthrop et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC)

(2019) Gloria Lliso-Ribera et al.   ANNALS OF THE RHEUMATIC DISEASES

Epigenetics in rheumatoid arthritis; fibroblast‐like synoviocytes as an emerging paradigm in the pathogenesis of the disease

(2019) Jafar Karami et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression and methylation levels of suppressor of cytokine signaling 3 in rheumatic arthritis synovial fibroblasts

(2019) Chunqing Meng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Defining refractory rheumatoid arthritis

(2018) Maya H Buch   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer

(2018) Nicholas S. Akins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Fibroblast heterogeneity: implications for human disease

(2018) Magnus D. Lynch et al.   JOURNAL OF CLINICAL INVESTIGATION

A short field guide to fibroblast function in immunity

(2018) Matthew B. Buechler et al.   SEMINARS IN IMMUNOLOGY

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

(2018) Marietta Armaka et al.   Nature Communications

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

(2018) William Stephenson et al.   Nature Communications

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

(2018) Emmanuel Karouzakis et al.   Scientific Reports

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis

(2018) Jane Falconer et al.   Arthritis & Rheumatology

Complement in the Initiation and Evolution of Rheumatoid Arthritis

(2018) V. Michael Holers et al.   Frontiers in Immunology

Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis

(2018) Marta F Bustamante et al.   ANNALS OF THE RHEUMATIC DISEASES

Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators

(2017) Hung N. Nguyen et al.   IMMUNITY

Immunopathogenesis of Rheumatoid Arthritis

(2017) Gary S. Firestein et al.   IMMUNITY

The epigenetic architecture at gene promoters determines cell type-specific LPS tolerance

(2017) Kerstin Klein et al.   JOURNAL OF AUTOIMMUNITY

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis

(2017) Yoshiya Tanaka et al.   Modern Rheumatology

Ectopic lymphoid neogenesis in rheumatic autoimmune diseases

(2017) Michele Bombardieri et al.   Nature Reviews Rheumatology

Why location matters — site-specific factors in rheumatic diseases

(2017) Caroline Ospelt et al.   Nature Reviews Rheumatology

The complement system as a potential therapeutic target in rheumatic disease

(2017) Leendert A. Trouw et al.   Nature Reviews Rheumatology

Joint morphogenetic cells in the adult mammalian synovium

(2017) Anke J. Roelofs et al.   Nature Communications

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

(2017) Mojca Frank-Bertoncelj et al.   Nature Communications

TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms

(2017) René Huber et al.   Journal of Immunology Research

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Epigenetic drug discovery: breaking through the immune barrier

(2016) David F. Tough et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis

(2016) Anca I. Catrina et al.   Nature Reviews Rheumatology

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role

(2016) S.J.B. Snelling et al.   OSTEOARTHRITIS AND CARTILAGE

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

(2016) Rizi Ai et al.   Nature Communications

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

(2015) Christopher D. Buckley et al.   Annual Review of Immunology

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation

(2015) Bartosz Pilecki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges

(2015) Josef S. Smolen et al.   Nature Reviews Rheumatology

Cytokines in rheumatoid arthritis — shaping the immunological landscape

(2015) Iain B. McInnes et al.   Nature Reviews Rheumatology

Stromal Transcriptional Profiles Reveal Hierarchies of Anatomical Site, Serum Response and Disease and Identify Disease Specific Pathways

(2015) Andrew Filer et al.   PLoS One

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

(2014) W den Hollander et al.   ANNALS OF THE RHEUMATIC DISEASES

Rsk2 controls synovial fibroblast hyperplasia and the course of arthritis

(2014) Anja Derer et al.   ANNALS OF THE RHEUMATIC DISEASES

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

(2014) Kerstin Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

Stroma: Fertile soil for inflammation

(2014) Rikesh Patel et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts

(2014) Takuma Tsuzuki Wada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The roles of IFN-γ versus IL-17 in pathogenic effects of human Th17 cells on synovial fibroblasts

(2014) Hiroshi Kato et al.   Modern Rheumatology

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

(2014) D. A. Jaitin et al.   SCIENCE

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

(2014) Glynn Dennis et al.   ARTHRITIS RESEARCH & THERAPY

Prolonged Tumor Necrosis Factor α Primes Fibroblast-like Synoviocytes in a Gene-Specific Manner by Altering Chromatin

(2014) Christopher Sohn et al.   Arthritis & Rheumatology

The fibroblast as a therapeutic target in rheumatoid arthritis

(2013) Andrew Filer   CURRENT OPINION IN PHARMACOLOGY

New learnings on the pathophysiology of RA from synovial biopsies

(2013) Costantino Pitzalis et al.   CURRENT OPINION IN RHEUMATOLOGY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

(2013) John W Whitaker et al.   Genome Medicine

Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Masaru Kato et al.   Arthritis & Rheumatology

Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis

(2012) Adelheid Korb-Pap et al.   ANNALS OF THE RHEUMATIC DISEASES

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow

(2012) Dorothy E. Pazin et al.   DEVELOPMENTAL DYNAMICS

Tissue stroma as a regulator of leukocyte recruitment in inflammation

(2012) Helen M. McGettrick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells

(2011) M. Bombardieri et al.   ANNALS OF THE RHEUMATIC DISEASES

RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: Immune regulation by vasoactive intestinal peptide

(2011) Mar Carrión et al.   ARTHRITIS AND RHEUMATISM

Characterization of CCL19 and CCL21 in rheumatoid arthritis

(2011) Sarah R. Pickens et al.   ARTHRITIS AND RHEUMATISM

Why does chronic inflammation persist: An unexpected role for fibroblasts

(2011) Christopher D. Buckley   IMMUNOLOGY LETTERS

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2

(2011) A. M. KERRIGAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cadherin-11 regulates fibroblast inflammation

(2011) S. K. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis

(2011) Anna-Karin H Ekwall et al.   ARTHRITIS RESEARCH & THERAPY

V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis

(2010) Tobias Scheel et al.   ARTHRITIS AND RHEUMATISM

Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture

(2010) Hans P. Kiener et al.   ARTHRITIS AND RHEUMATISM

Migratory potential of rheumatoid arthritis synovial fibroblasts: Additional perspectives

(2010) Elena Neumann et al.   CELL CYCLE

Current aspects of anti-CD20 therapy in rheumatoid arthritis

(2010) Annett M Jacobi et al.   CURRENT OPINION IN PHARMACOLOGY

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

Rheumatoid arthritis progression mediated by activated synovial fibroblasts

(2010) Elena Neumann et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress

(2010) Yong-Joo Shin et al.   ARTHRITIS RESEARCH & THERAPY

Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts

(2010) Elena Neumann et al.   ARTHRITIS RESEARCH & THERAPY

Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis

(2009) A. Jungel et al.   ANNALS OF THE RHEUMATIC DISEASES

Cell death in rheumatoid arthritis

(2009) Adelheid Korb et al.   APOPTOSIS

Inhibitor of DNA binding/differentiation 2 induced by hypoxia promotes synovial fibroblast–dependent osteoclastogenesis

(2009) Mariola Kurowska-Stolarska et al.   ARTHRITIS AND RHEUMATISM

Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes

(2009) Hans P. Kiener et al.   ARTHRITIS AND RHEUMATISM

Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways

(2009) Andrew Filer et al.   ARTHRITIS AND RHEUMATISM

Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells

(2009) Helen M. McGettrick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling

(2009) Antonio Manzo et al.   IMMUNOLOGICAL REVIEWS

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Overexpression ofREIC/Dkk-3in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7

(2009) Masakiyo Sakaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts

(2009) M. HORIUCHI et al.   JOURNAL OF RHEUMATOLOGY

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

A dermal HOX transcriptional program regulates site-specific epidermal fate

(2008) J. L. Rinn et al.   GENES & DEVELOPMENT

Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness

(2008) T. Montavon et al.   GENES & DEVELOPMENT

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

(2008) Maria Armaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab

(2008) Sanna Rosengren et al.   ARTHRITIS RESEARCH & THERAPY