Ectopic lymphoid neogenesis in rheumatic autoimmune diseases

Towards personalised treatment in primary Sjögren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment

(2016) Konstantina Delli et al.   ANNALS OF THE RHEUMATIC DISEASES

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

(2016) Shaun W. Jackson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity

(2016) Phillip P. Domeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

(2015) Elisa Corsiero et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-22: Immunobiology and Pathology

(2015) Jarrod A. Dudakov et al.   Annual Review of Immunology

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis

(2015) Gareth W. Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trojan horses and guided missiles: targeted therapies in the war on arthritis

(2015) Mathieu Ferrari et al.   Nature Reviews Rheumatology

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

(2015) Francesca Barone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types

(2015) Erika H. Noss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

(2015) Juan D. Cañete et al.   ARTHRITIS RESEARCH & THERAPY

Introducing the New Editor of Arthritis & Rheumatology , Richard J. Bucala, MD, PhD

(2015) E. William St.Clair   Arthritis & Rheumatology

Abatacept or tocilizumab after rituximab in rheumatoid arthritis? An exploratory study suggests non-response to rituximab is associated with persistently high IL-6 and better clinical response to IL-6 blocking therapy

(2014) Sudipto Das et al.   ANNALS OF THE RHEUMATIC DISEASES

Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sjögren's syndrome

(2014) Ya-Zhuo Gong et al.   JOURNAL OF AUTOIMMUNITY

CXCL13, CCL21, and CXCL12 Expression in Salivary Glands of Patients with Sjogren's Syndrome and MALT Lymphoma: Association with Reactive and Malignant Areas of Lymphoid Organization

(2014) F. Barone et al.   JOURNAL OF IMMUNOLOGY

B Lymphocyte Autoimmunity in Rheumatoid Synovitis Is Independent of Ectopic Lymphoid Neogenesis

(2014) T. Cantaert et al.   JOURNAL OF IMMUNOLOGY

B7RP-1 Blockade Ameliorates Autoimmunity through Regulation of Follicular Helper T Cells

(2014) Y.-L. Hu et al.   JOURNAL OF IMMUNOLOGY

The development and function of mucosal lymphoid tissues: a balancing act with micro-organisms

(2014) T D Randall et al.   Mucosal Immunology

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

(2014) Dan Liu et al.   NATURE

High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease

(2014) Serena Bugatti et al.   RHEUMATOLOGY

Dynamic signaling by T follicular helper cells during germinal center B cell selection

(2014) Z. Shulman et al.   SCIENCE

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

(2014) Glynn Dennis et al.   ARTHRITIS RESEARCH & THERAPY

Implication of Epstein-Barr Virus Infection in Disease-Specific Autoreactive B Cell Activation in Ectopic Lymphoid Structures of Sjögren's Syndrome

(2014) Cristina Croia et al.   Arthritis & Rheumatology

Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity

(2013) M E Doorenspleet et al.   ANNALS OF THE RHEUMATIC DISEASES

A Distinct Human CD4+ T Cell Subset That Secretes CXCL13 in Rheumatoid Synovium

(2013) Shio Kobayashi et al.   ARTHRITIS AND RHEUMATISM

New learnings on the pathophysiology of RA from synovial biopsies

(2013) Costantino Pitzalis et al.   CURRENT OPINION IN RHEUMATOLOGY

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of Histologic, Serologic, and Clinical Changes in Response to Abatacept Treatment of Primary Sjögren's Syndrome: A Pilot Study

(2013) Sabine Adler et al.   ARTHRITIS CARE & RESEARCH

Persistence of immunoglobulin-producing cells in parotid salivary glands of patients with primary Sjögren's syndrome after B cell depletion therapy

(2012) Nishath Hamza et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease

(2012) P L Klarenbeek et al.   ANNALS OF THE RHEUMATIC DISEASES

Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway

(2012) Saba Alzabin et al.   ANNALS OF THE RHEUMATIC DISEASES

Epstein–Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis

(2012) Cristina Croia et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of Intrarenal B-Cell Infiltrates with Clinical Outcome in Lupus Nephritis: A Study of 192 Cases

(2012) Yan Shen et al.   Clinical & Developmental Immunology

Synovium CD20 expression is a potential new predictor of bone erosion progression in very-early arthritis treated by sequential DMARDs monotherapy – A pilot study from the VErA cohort

(2012) Karine Lanfant-Weybel et al.   JOINT BONE SPINE

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells

(2012) Matthieu Mahévas et al.   JOURNAL OF CLINICAL INVESTIGATION

Inducible Tertiary Lymphoid Structures, Autoimmunity, and Exocrine Dysfunction in a Novel Model of Salivary Gland Inflammation in C57BL/6 Mice

(2012) M. Bombardieri et al.   JOURNAL OF IMMUNOLOGY

Local suppression of IL-21 in submandibular glands retards the development of Sjögren’s syndrome in non-obese diabetic mice

(2012) Hao Liu et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

The Role of Ectopic Germinal Centers in the Immunopathology of Primary Sjögren's Syndrome: A Systematic Review

(2012) Anna P. Risselada et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Gene therapy using IL-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathy

(2012) Byung Lee et al.   ARTHRITIS RESEARCH & THERAPY

The Interplay of IL-21 and BAFF in the Formation and Maintenance of Human B Cell Memory

(2012) Jodi L. Karnell et al.   Frontiers in Immunology

Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome

(2011) E. Theander et al.   ANNALS OF THE RHEUMATIC DISEASES

Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjögren's syndrome

(2011) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells

(2011) M. Bombardieri et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis

(2011) Seung-Ki Kwok et al.   ARTHRITIS AND RHEUMATISM

Interferon-α induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice

(2011) Alexis Mathian et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Salivary glands of primary Sjogren's syndrome patients express factors vital for plasma cell survival

(2011) Ewa A Szyszko et al.   ARTHRITIS RESEARCH & THERAPY

Presence of lymphocyte aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: is it a constant feature over time?

(2010) M. G. H. van de Sande et al.   ANNALS OF THE RHEUMATIC DISEASES

Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner

(2010) Zheng Liu et al.   ARTHRITIS AND RHEUMATISM

V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis

(2010) Tobias Scheel et al.   ARTHRITIS AND RHEUMATISM

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

(2010) Marcel Batten et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Situ B Cell-Mediated Immune Responses and Tubulointerstitial Inflammation in Human Lupus Nephritis

(2010) A. Chang et al.   JOURNAL OF IMMUNOLOGY

Local Renal Autoantibody Production in Lupus Nephritis

(2010) M. Espeli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intrarenal production of B-cell survival factors in human lupus nephritis

(2010) Matthias A Neusser et al.   MODERN PATHOLOGY

Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles

(2010) Mohammad Salajegheh et al.   MUSCLE & NERVE

CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis

(2010) S. Rosengren et al.   RHEUMATOLOGY

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: A prospective study

(2009) Ruth Klaasen et al.   ARTHRITIS AND RHEUMATISM

Extranodal lymphoid microstructures in inflamed muscle and disease severity of new-onset juvenile dermatomyositis

(2009) Consuelo M. López De Padilla et al.   ARTHRITIS AND RHEUMATISM

Clinical and histologic evidence of salivary gland restoration supports the efficacy of rituximab treatment in Sjögren's syndrome

(2009) J. Pijpe et al.   ARTHRITIS AND RHEUMATISM

Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling

(2009) Antonio Manzo et al.   IMMUNOLOGICAL REVIEWS

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus–infected mice

(2009) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ectopic Germinal Centers Are Rare in Sjogren's Syndrome Salivary Glands and Do Not Exclude Autoreactive B Cells

(2009) L. Le Pottier et al.   JOURNAL OF IMMUNOLOGY

Increased Expression of Activation-Induced Cytidine Deaminase is Associated with Anti-CCP and Rheumatoid Factor in Rheumatoid Arthritis

(2009) X. Xu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren syndrome in salivary glands of non-obese diabetic mice

(2009) Margaret K Gatumu et al.   ARTHRITIS RESEARCH & THERAPY

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation

(2008) Y K O Teng et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor   therapy in rheumatoid arthritis

(2008) J D Canete et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype

(2008) Rogier M. Thurlings et al.   ARTHRITIS AND RHEUMATISM

Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint

(2008) Antonio Manzo et al.   ARTHRITIS AND RHEUMATISM

The value of synovial cytokine expression in predicting the clinical response to TNF antagonist therapy (infliximab)

(2008) M. H. Buch et al.   RHEUMATOLOGY

Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab

(2008) Sanna Rosengren et al.   ARTHRITIS RESEARCH & THERAPY