The complement system as a potential therapeutic target in rheumatic disease

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Complement in ANCA-associated vasculitis: mechanisms and implications for management

(2017) Min Chen et al.   Nature Reviews Nephrology

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis

(2017) Leendert A. Trouw et al.   Nature Reviews Rheumatology

Complement activation in pauci-immune necrotizing and crescentic glomerulonephritis: results of a proteomic analysis

(2017) Sanjeev Sethi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

On the value of therapeutic interventions targeting the complement system in acute myocardial infarction

(2017) Reindert W. Emmens et al.   Translational Research

Paroxysmal nocturnal haemoglobinuria

(2017) Anita Hill et al.   Nature Reviews Disease Primers

Plasma-Derived C1 Esterase Inhibitor for Acute Antibody-Mediated Rejection Following Kidney Transplantation: Results of a Randomized Double-Blind Placebo-Controlled Pilot Study

(2016) R. A. Montgomery et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice

(2016) Anja C. Bloom et al.   BONE

Infections associated with the use of eculizumab

(2016) Esther Benamu et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Targeting mechanisms at sites of complement activation for imaging and therapy

(2016) V. Michael Holers   IMMUNOBIOLOGY

Complement analysis 2016: Clinical indications, laboratory diagnostics and quality control

(2016) Zoltán Prohászka et al.   IMMUNOBIOLOGY

Complement in removal of the dead - balancing inflammation

(2016) Myriam Martin et al.   IMMUNOLOGICAL REVIEWS

Use of Eculizumab in Atypical Hemolytic Uremic Syndrome, Complicating Systemic Lupus Erythematosus

(2016) Rene S. Bermea et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Quantitative Mass Spectrometry To Study Inflammatory Cartilage Degradation and Resulting Interactions with the Complement System

(2016) Camilla Melin Fürst et al.   JOURNAL OF IMMUNOLOGY

Novelties in the Diagnosis and Treatment of Angioedema

(2016) M Cicardi et al.   JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY

The production and secretion of complement component C1q by human mast cells

(2016) Rosanne A. van Schaarenburg et al.   MOLECULAR IMMUNOLOGY

Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components

(2016) Juha Kotimaa et al.   MOLECULAR IMMUNOLOGY

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

ANCA-associated vasculitis — clinical utility of using ANCA specificity to classify patients

(2016) Divi Cornec et al.   Nature Reviews Rheumatology

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

New milestones ahead in complement-targeted therapy

(2016) Daniel Ricklin et al.   SEMINARS IN IMMUNOLOGY

New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities

(2016) V. Michael Holers et al.   SEMINARS IN IMMUNOLOGY

Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of Human C1q Deficiency

(2016) Richard F. Olsson et al.   TRANSPLANTATION

Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study

(2016) Roberta C. Gomes et al.   ARTHRITIS CARE & RESEARCH

Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical Pathway

(2016) Ana Catarina Lunz Macedo et al.   Frontiers in Immunology

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

(2016) Katherine E. Lintner et al.   Frontiers in Immunology

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

(2016) Pirow Bekker et al.   PLoS One

Thrombotic Microangiopathy in Systemic Lupus Erythematosus: Efficacy of Eculizumab

(2015) Amr El-Husseini et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Targeting Pathogenic Postischemic Self-Recognition by Natural IgM to Protect Against Posttransplantation Cardiac Reperfusion InjuryCLINICAL PERSPECTIVE

(2015) Carl Atkinson et al.   CIRCULATION

Neutrophil extracellular traps can activate alternative complement pathways

(2015) H. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome

(2015) Elena B. Volokhina et al.   CLINICAL IMMUNOLOGY

A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA

(2015) Gaurav Mehta et al.   JOURNAL OF IMMUNOLOGY

C1q, antibodies and anti-C1q autoantibodies

(2015) Frank J. Beurskens et al.   MOLECULAR IMMUNOLOGY

Antibodies reactive to cleaved sites in complement proteins enable highly specific measurement of soluble markers of complement activation

(2015) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

Atypical aHUS: State of the art

(2015) Carla M. Nester et al.   MOLECULAR IMMUNOLOGY

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2015) Edwin K.S. Wong et al.   Translational Research

The Clinical Spectrum and Therapeutic Management of Hypocomplementemic Urticarial Vasculitis: Data From a French Nationwide Study of Fifty-Seven Patients

(2015) Marie Jachiet et al.   Arthritis & Rheumatology

The complement system in systemic lupus erythematosus: an update

(2014) Jonatan Leffler et al.   ANNALS OF THE RHEUMATIC DISEASES

Vasculitides and the Complement System: a Comprehensive Review

(2014) Maria Sole Chimenti et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Essential Role for the Lectin Pathway in Collagen Antibody–Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression

(2014) Nirmal K. Banda et al.   JOURNAL OF IMMUNOLOGY

Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach

(2014) Anete Sevciovic Grumach et al.   MOLECULAR IMMUNOLOGY

IgG1 protects against renal disease in a mouse model of cryoglobulinaemia

(2014) Richard T. Strait et al.   NATURE

Dramatic effects of eculizumab in a child with diffuse proliferative lupus nephritis resistant to conventional therapy

(2014) Rosanna Coppo et al.   PEDIATRIC NEPHROLOGY

Eculizumab treatment for rescue of renal function in IgA nephropathy

(2014) Therese Rosenblad et al.   PEDIATRIC NEPHROLOGY

Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis

(2013) Parawee Suwannalai et al.   ANNALS OF THE RHEUMATIC DISEASES

Proteomic Analysis of Synovial Fluid From the Osteoarthritic Knee: Comparison With Transcriptome Analyses of Joint Tissues

(2013) Susan Y. Ritter et al.   ARTHRITIS AND RHEUMATISM

Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation

(2013) Peter D. Arkwright et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoantibodies against complement components and functional consequences

(2013) Marie-Agnès Dragon-Durey et al.   MOLECULAR IMMUNOLOGY

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention of Arthritis by Locally Synthesized Recombinant Antibody Neutralizing Complement Component C5

(2013) Paolo Durigutto et al.   PLoS One

The C-Type Lectin of the Aggrecan G3 Domain Activates Complement

(2013) Camilla Melin Fürst et al.   PLoS One

Brief Report: Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis

(2013) Christin M. Lepus et al.   Arthritis & Rheumatology

Anti-C1q Autoantibodies, Novel Tests, and Clinical Consequences

(2013) Michael Mahler et al.   Frontiers in Immunology

Treatment of experimental arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5

(2012) Paolo Macor et al.   ARTHRITIS AND RHEUMATISM

2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides

(2012) J. C. Jennette et al.   ARTHRITIS AND RHEUMATISM

Complement Diagnostics: Concepts, Indications, and Practical Guidelines

(2012) Bo Nilsson et al.   Clinical & Developmental Immunology

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody–associated vasculitis

(2012) Shen-Ju Gou et al.   KIDNEY INTERNATIONAL

STEC-HUS, atypical HUS and TTP are all diseases of complement activation

(2012) Marina Noris et al.   Nature Reviews Nephrology

Complement in the immunopathogenesis of rheumatic disease

(2012) Gunnar Sturfelt et al.   Nature Reviews Rheumatology

C1q limits dendritic cell differentiation and activation by engaging LAIR-1

(2012) M. Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis

(2012) Jun Yuan et al.   ARTHRITIS RESEARCH & THERAPY

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Role of C3a Receptors, C5a Receptors, and Complement Protein C6 Deficiency in Collagen Antibody-Induced Arthritis in Mice

(2011) N. K. Banda et al.   JOURNAL OF IMMUNOLOGY

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria

(2010) Peter Hillmen et al.   AMERICAN JOURNAL OF HEMATOLOGY

Synovial fluid levels of complement SC5b-9 and fragment Bb are elevated in patients with rheumatoid arthritis

(2010) James P. Brodeur et al.   ARTHRITIS AND RHEUMATISM

Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis

(2010) Kaisa E. Happonen et al.   ARTHRITIS AND RHEUMATISM

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

(2010) L. Camous et al.   BLOOD

Infections of People with Complement Deficiencies and Patients Who Have Undergone Splenectomy

(2010) S. Ram et al.   CLINICAL MICROBIOLOGY REVIEWS

C1q inhibits immune complex-induced interferon-α production in plasmacytoid dendritic cells: A novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

(2009) Christian Lood et al.   ARTHRITIS AND RHEUMATISM

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

(2009) L. A. Trouw et al.   ARTHRITIS AND RHEUMATISM

Targeted Inhibition of the Complement Alternative Pathway with Complement Receptor 2 and Factor H Attenuates Collagen Antibody-Induced Arthritis in Mice

(2009) N. K. Banda et al.   JOURNAL OF IMMUNOLOGY

ANCA-negative pauci-immune crescentic glomerulonephritis

(2009) Min Chen et al.   Nature Reviews Nephrology

SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience

(2009) P. Mehta et al.   RHEUMATOLOGY

C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice

(2008) A M Blom et al.   ANNALS OF THE RHEUMATIC DISEASES

Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis

(2008) Guang-qun Xing et al.   JOURNAL OF CLINICAL IMMUNOLOGY

C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis

(2008) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation

(2008) Andreas P. Sjöberg et al.   MOLECULAR IMMUNOLOGY

Role of complement and complement regulators in the removal of apoptotic cells

(2007) L.A. Trouw et al.   MOLECULAR IMMUNOLOGY