标题
Fibroblast pathology in inflammatory joint disease
作者
关键词
-
出版物
IMMUNOLOGICAL REVIEWS
Volume 302, Issue 1, Pages 163-183
出版商
Wiley
发表日期
2021-06-07
DOI
10.1111/imr.12986
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- LncRNA NEAT1 regulates the proliferation and production of the inflammatory cytokines in rheumatoid arthritis fibroblast-like synoviocytes by targeting miR-204-5p
- (2021) Jianwei Xiao et al. Human Cell
- Mapping the musculoskeletal system one cell at a time
- (2021) Mathew J. Baldwin et al. Nature Reviews Rheumatology
- Location, location, location: how the tissue microenvironment affects inflammation in RA
- (2021) Christopher D. Buckley et al. Nature Reviews Rheumatology
- MicroRNA‑23a‑5p regulates cell proliferation, migration and inflammation of TNF‑α‑stimulated human fibroblast‑like MH7A synoviocytes by targeting TLR4 in rheumatoid arthritis
- (2021) Xiao Bao et al. Experimental and Therapeutic Medicine
- The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts
- (2021) Jasna Friščić et al. IMMUNITY
- Origin and functional heterogeneity of fibroblasts
- (2020) Valerie S. LeBleu et al. FASEB JOURNAL
- Single-cell genomic approaches for developing the next generation of immunotherapies
- (2020) Ido Yofe et al. NATURE MEDICINE
- Involvement of long non-coding RNAs in the pathogenesis of rheumatoid arthritis
- (2020) Min-Xi Lao et al. CHINESE MEDICAL JOURNAL
- Notch signalling drives synovial fibroblast identity and arthritis pathology
- (2020) Kevin Wei et al. NATURE
- Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
- (2020) Gyrid Nygaard et al. Nature Reviews Rheumatology
- Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis
- (2020) Xuezhi Yang et al. CELL PROLIFERATION
- The mesenchymal context in inflammation, immunity and cancer
- (2020) Vasiliki Koliaraki et al. NATURE IMMUNOLOGY
- Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
- (2020) Stefano Alivernini et al. NATURE MEDICINE
- RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares
- (2020) Dana E. Orange et al. NEW ENGLAND JOURNAL OF MEDICINE
- Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4
- (2020) Yoshihide Ichise et al. Cells
- Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: First report of FAPME, a phase I clinical trial
- (2020) S. Hiltbrunner et al. ANNALS OF ONCOLOGY
- CADM1 enhances intestinal barrier function in a rat model of mild inflammatory bowel disease by inhibiting the STAT3 signaling pathway
- (2020) Shengtao Sun et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-κB axis
- (2020) Jinghan Yang et al. Cell Death & Disease
- Why remission is not enough: underlying disease mechanisms in RA that prevent cure
- (2020) Georg Schett et al. Nature Reviews Rheumatology
- Chimeric Antigen Receptor Based Therapy as a Potential Approach in Autoimmune Diseases: How Close Are We to the Treatment?
- (2020) Muhammad Sadeqi Nezhad et al. Frontiers in Immunology
- Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity
- (2019) Santiago P. Mendez-Huergo et al. Frontiers in Immunology
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
- (2019) Yang Yang et al. Cell Death & Disease
- Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients
- (2019) Frances Humby et al. ANNALS OF THE RHEUMATIC DISEASES
- TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis
- (2019) Christopher Loh et al. ANNALS OF THE RHEUMATIC DISEASES
- RGS1 silencing inhibits the inflammatory response and angiogenesis in rheumatoid arthritis rats through the inactivation of Toll‐like receptor signaling pathway
- (2019) Xumin Hu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Distinct fibroblast subsets drive inflammation and damage in arthritis
- (2019) Adam P. Croft et al. NATURE
- Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
- (2019) Fan Zhang et al. NATURE IMMUNOLOGY
- HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness
- (2019) David Kuo et al. Science Translational Medicine
- A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages
- (2019) Matthew B. Buechler et al. IMMUNITY
- Clinical promise of next-generation complement therapeutics
- (2019) Dimitrios C. Mastellos et al. NATURE REVIEWS DRUG DISCOVERY
- Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes
- (2019) Hiroyuki Yoshitomi Frontiers in Immunology
- Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis
- (2019) Marina V. Nemtsova et al. Frontiers in Genetics
- Locally renewing resident synovial macrophages provide a protective barrier for the joint
- (2019) Stephan Culemann et al. NATURE
- Targeting cardiac fibrosis with engineered T cells
- (2019) Haig Aghajanian et al. NATURE
- Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes
- (2019) Myles J. Lewis et al. Cell Reports
- DNA Methylation as a Future Therapeutic and Diagnostic Target in Rheumatoid Arthritis
- (2019) Marzena Ciechomska et al. Cells
- Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019
- (2019) Kevin L Winthrop et al. ANNALS OF THE RHEUMATIC DISEASES
- Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC)
- (2019) Gloria Lliso-Ribera et al. ANNALS OF THE RHEUMATIC DISEASES
- Epigenetics in rheumatoid arthritis; fibroblast‐like synoviocytes as an emerging paradigm in the pathogenesis of the disease
- (2019) Jafar Karami et al. IMMUNOLOGY AND CELL BIOLOGY
- Expression and methylation levels of suppressor of cytokine signaling 3 in rheumatic arthritis synovial fibroblasts
- (2019) Chunqing Meng et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Defining refractory rheumatoid arthritis
- (2018) Maya H Buch ANNALS OF THE RHEUMATIC DISEASES
- Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer
- (2018) Nicholas S. Akins et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Fibroblast heterogeneity: implications for human disease
- (2018) Magnus D. Lynch et al. JOURNAL OF CLINICAL INVESTIGATION
- A short field guide to fibroblast function in immunity
- (2018) Matthew B. Buechler et al. SEMINARS IN IMMUNOLOGY
- The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
- (2018) Marietta Armaka et al. Nature Communications
- Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
- (2018) Fumitaka Mizoguchi et al. Nature Communications
- Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
- (2018) William Stephenson et al. Nature Communications
- Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis
- (2018) Emmanuel Karouzakis et al. Scientific Reports
- JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis
- (2018) Trudy McGarry et al. Arthritis & Rheumatology
- Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis
- (2018) Jane Falconer et al. Arthritis & Rheumatology
- Complement in the Initiation and Evolution of Rheumatoid Arthritis
- (2018) V. Michael Holers et al. Frontiers in Immunology
- Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis
- (2018) Marta F Bustamante et al. ANNALS OF THE RHEUMATIC DISEASES
- Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators
- (2017) Hung N. Nguyen et al. IMMUNITY
- Immunopathogenesis of Rheumatoid Arthritis
- (2017) Gary S. Firestein et al. IMMUNITY
- The epigenetic architecture at gene promoters determines cell type-specific LPS tolerance
- (2017) Kerstin Klein et al. JOURNAL OF AUTOIMMUNITY
- Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis
- (2017) Yoshiya Tanaka et al. Modern Rheumatology
- Ectopic lymphoid neogenesis in rheumatic autoimmune diseases
- (2017) Michele Bombardieri et al. Nature Reviews Rheumatology
- Why location matters — site-specific factors in rheumatic diseases
- (2017) Caroline Ospelt et al. Nature Reviews Rheumatology
- The complement system as a potential therapeutic target in rheumatic disease
- (2017) Leendert A. Trouw et al. Nature Reviews Rheumatology
- Joint morphogenetic cells in the adult mammalian synovium
- (2017) Anke J. Roelofs et al. Nature Communications
- Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
- (2017) Mojca Frank-Bertoncelj et al. Nature Communications
- TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms
- (2017) René Huber et al. Journal of Immunology Research
- Rheumatoid arthritis
- (2016) Josef S Smolen et al. LANCET
- Epigenetic drug discovery: breaking through the immune barrier
- (2016) David F. Tough et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis
- (2016) Anca I. Catrina et al. Nature Reviews Rheumatology
- Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis
- (2016) Ursula Fearon et al. Nature Reviews Rheumatology
- Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role
- (2016) S.J.B. Snelling et al. OSTEOARTHRITIS AND CARTILAGE
- Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
- (2016) Rizi Ai et al. Nature Communications
- Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation
- (2015) Christopher D. Buckley et al. Annual Review of Immunology
- Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation
- (2015) Bartosz Pilecki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges
- (2015) Josef S. Smolen et al. Nature Reviews Rheumatology
- Cytokines in rheumatoid arthritis — shaping the immunological landscape
- (2015) Iain B. McInnes et al. Nature Reviews Rheumatology
- Stromal Transcriptional Profiles Reveal Hierarchies of Anatomical Site, Serum Response and Disease and Identify Disease Specific Pathways
- (2015) Andrew Filer et al. PLoS One
- Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches
- (2014) W den Hollander et al. ANNALS OF THE RHEUMATIC DISEASES
- Rsk2 controls synovial fibroblast hyperplasia and the course of arthritis
- (2014) Anja Derer et al. ANNALS OF THE RHEUMATIC DISEASES
- The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts
- (2014) Kerstin Klein et al. ANNALS OF THE RHEUMATIC DISEASES
- Stroma: Fertile soil for inflammation
- (2014) Rikesh Patel et al. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
- Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts
- (2014) Takuma Tsuzuki Wada et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The roles of IFN-γ versus IL-17 in pathogenic effects of human Th17 cells on synovial fibroblasts
- (2014) Hiroshi Kato et al. Modern Rheumatology
- Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types
- (2014) D. A. Jaitin et al. SCIENCE
- Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics
- (2014) Glynn Dennis et al. ARTHRITIS RESEARCH & THERAPY
- Prolonged Tumor Necrosis Factor α Primes Fibroblast-like Synoviocytes in a Gene-Specific Manner by Altering Chromatin
- (2014) Christopher Sohn et al. Arthritis & Rheumatology
- The fibroblast as a therapeutic target in rheumatoid arthritis
- (2013) Andrew Filer CURRENT OPINION IN PHARMACOLOGY
- New learnings on the pathophysiology of RA from synovial biopsies
- (2013) Costantino Pitzalis et al. CURRENT OPINION IN RHEUMATOLOGY
- Distinct fibroblast lineages determine dermal architecture in skin development and repair
- (2013) Ryan R. Driskell et al. NATURE
- Tissue-resident macrophages
- (2013) Luke C Davies et al. NATURE IMMUNOLOGY
- An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype
- (2013) John W Whitaker et al. Genome Medicine
- Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts
- (2013) Masaru Kato et al. Arthritis & Rheumatology
- Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis
- (2012) Adelheid Korb-Pap et al. ANNALS OF THE RHEUMATIC DISEASES
- DNA methylome signature in rheumatoid arthritis
- (2012) Kazuhisa Nakano et al. ANNALS OF THE RHEUMATIC DISEASES
- Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow
- (2012) Dorothy E. Pazin et al. DEVELOPMENTAL DYNAMICS
- Tissue stroma as a regulator of leukocyte recruitment in inflammation
- (2012) Helen M. McGettrick et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
- (2012) Deepali Malhotra et al. NATURE IMMUNOLOGY
- Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors
- (2012) Nunzio Bottini et al. Nature Reviews Rheumatology
- A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells
- (2011) M. Bombardieri et al. ANNALS OF THE RHEUMATIC DISEASES
- RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: Immune regulation by vasoactive intestinal peptide
- (2011) Mar Carrión et al. ARTHRITIS AND RHEUMATISM
- Characterization of CCL19 and CCL21 in rheumatoid arthritis
- (2011) Sarah R. Pickens et al. ARTHRITIS AND RHEUMATISM
- Why does chronic inflammation persist: An unexpected role for fibroblasts
- (2011) Christopher D. Buckley IMMUNOLOGY LETTERS
- Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2
- (2011) A. M. KERRIGAN et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- The Pathogenesis of Rheumatoid Arthritis
- (2011) Iain B. McInnes et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cadherin-11 regulates fibroblast inflammation
- (2011) S. K. Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis
- (2011) Anna-Karin H Ekwall et al. ARTHRITIS RESEARCH & THERAPY
- V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis
- (2010) Tobias Scheel et al. ARTHRITIS AND RHEUMATISM
- Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture
- (2010) Hans P. Kiener et al. ARTHRITIS AND RHEUMATISM
- Migratory potential of rheumatoid arthritis synovial fibroblasts: Additional perspectives
- (2010) Elena Neumann et al. CELL CYCLE
- Current aspects of anti-CD20 therapy in rheumatoid arthritis
- (2010) Annett M Jacobi et al. CURRENT OPINION IN PHARMACOLOGY
- Epigenetics and gene expression
- (2010) E R Gibney et al. HEREDITY
- Rheumatoid arthritis progression mediated by activated synovial fibroblasts
- (2010) Elena Neumann et al. TRENDS IN MOLECULAR MEDICINE
- Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress
- (2010) Yong-Joo Shin et al. ARTHRITIS RESEARCH & THERAPY
- Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts
- (2010) Elena Neumann et al. ARTHRITIS RESEARCH & THERAPY
- Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis
- (2009) A. Jungel et al. ANNALS OF THE RHEUMATIC DISEASES
- Cell death in rheumatoid arthritis
- (2009) Adelheid Korb et al. APOPTOSIS
- Inhibitor of DNA binding/differentiation 2 induced by hypoxia promotes synovial fibroblastâdependent osteoclastogenesis
- (2009) Mariola Kurowska-Stolarska et al. ARTHRITIS AND RHEUMATISM
- Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes
- (2009) Hans P. Kiener et al. ARTHRITIS AND RHEUMATISM
- Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways
- (2009) Andrew Filer et al. ARTHRITIS AND RHEUMATISM
- Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells
- (2009) Helen M. McGettrick et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling
- (2009) Antonio Manzo et al. IMMUNOLOGICAL REVIEWS
- Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
- (2009) Beatrix Bartok et al. IMMUNOLOGICAL REVIEWS
- Overexpression ofREIC/Dkk-3in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7
- (2009) Masakiyo Sakaguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts
- (2009) M. HORIUCHI et al. JOURNAL OF RHEUMATOLOGY
- Synovial fibroblasts spread rheumatoid arthritis to unaffected joints
- (2009) Stephanie Lefèvre et al. NATURE MEDICINE
- Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
- (2009) Frances Humby et al. PLOS MEDICINE
- IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
- (2008) P. Emery et al. ANNALS OF THE RHEUMATIC DISEASES
- Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis
- (2008) Caroline Ospelt et al. ARTHRITIS AND RHEUMATISM
- Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
- (2008) Joanna Stanczyk et al. ARTHRITIS AND RHEUMATISM
- A dermal HOX transcriptional program regulates site-specific epidermal fate
- (2008) J. L. Rinn et al. GENES & DEVELOPMENT
- Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness
- (2008) T. Montavon et al. GENES & DEVELOPMENT
- Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
- (2008) Maria Armaka et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab
- (2008) Sanna Rosengren et al. ARTHRITIS RESEARCH & THERAPY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation