Why location matters — site-specific factors in rheumatic diseases

The changing role of TGFβ in healthy, ageing and osteoarthritic joints

(2017) Peter M. van der Kraan   Nature Reviews Rheumatology

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

(2017) Mojca Frank-Bertoncelj et al.   Nature Communications

Physical trauma recorded in primary care is associated with the onset of psoriatic arthritis among patients with psoriasis

(2016) Stefán Már Thorarensen et al.   ANNALS OF THE RHEUMATIC DISEASES

Deletions of 5′HOXCgenes are associated with lower extremity malformations, including clubfoot and vertical talus

(2016) David M Alvarado et al.   JOURNAL OF MEDICAL GENETICS

Cell-type specific variation in the induction of ER stress and downstream events in chikungunya virus infection

(2016) Sarawut Khongwichit et al.   MICROBIAL PATHOGENESIS

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue

(2016) Jason M. Knight et al.   PHYSIOLOGICAL GENOMICS

Active Foot Synovitis in Patients With Rheumatoid Arthritis: Unstable Remission Status, Radiographic Progression, and Worse Functional Outcomes in Patients With Foot Synovitis in Apparent Remission

(2016) Mihir D. Wechalekar et al.   ARTHRITIS CARE & RESEARCH

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

(2016) Rizi Ai et al.   Nature Communications

Joint Development Involves a Continuous Influx of Gdf5-Positive Cells

(2016) Yulia Shwartz et al.   Cell Reports

HLA-B27

(2015) Paul Bowness   Annual Review of Immunology

Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis

(2015) Erfan Aref-Eshghi et al.   BMC MUSCULOSKELETAL DISORDERS

Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro

(2015) Gopu Sriram et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The disruption of a novel limb cis-regulatory element of SHH is associated with autosomal dominant preaxial polydactyly-hypertrichosis

(2015) Florence Petit et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Atherosclerosis in rheumatoid arthritis: is it all about inflammation?

(2015) Sarah Skeoch et al.   Nature Reviews Rheumatology

Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype

(2015) Oliver FitzGerald et al.   ARTHRITIS RESEARCH & THERAPY

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

(2014) W den Hollander et al.   ANNALS OF THE RHEUMATIC DISEASES

Certain class I HLA alleles and haplotypes implicated in susceptibility play a role in determining specific features of the psoriatic arthritis phenotype

(2014) Muhammad Haroon et al.   ANNALS OF THE RHEUMATIC DISEASES

The role of mechanical stress in the pathogenesis of spondyloarthritis and how to combat it

(2014) Peggy Jacques et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application

(2014) Sanjay Sinha et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications

(2014) Katherine E. Pinnick et al.   DIABETES

CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383

(2014) Louise N. Reynard et al.   HUMAN GENETICS

Epigenome Analysis Reveals TBX5 as a Novel Transcription Factor Involved in the Activation of Rheumatoid Arthritis Synovial Fibroblasts

(2014) Emmanuel Karouzakis et al.   JOURNAL OF IMMUNOLOGY

A Normative Study of the Synovial Fluid Proteome from Healthy Porcine Knee Joints

(2014) Tue Bennike et al.   JOURNAL OF PROTEOME RESEARCH

Genesis and morphogenesis of limb synovial joints and articular cartilage

(2014) Rebekah S. Decker et al.   MATRIX BIOLOGY

Vasculitis: determinants of disease patterns

(2014) Gary S. Hoffman et al.   Nature Reviews Rheumatology

Transcript Analysis Reveals a Specific HOX Signature Associated with Positional Identity of Human Endothelial Cells

(2014) Mark Toshner et al.   PLoS One

Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature

(2014) L. Stangenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult human neural crest-derived cells for articular cartilage repair

(2014) K. Pelttari et al.   Science Translational Medicine

Inflammatory Bone Spur Formation in Psoriatic Arthritis Is Different From Bone Spur Formation in Hand Osteoarthritis

(2014) Stephanie Finzel et al.   Arthritis & Rheumatology

Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis

(2014) Michael D. Rushton et al.   Arthritis & Rheumatology

Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis

(2013) Erin Teeple et al.   AAPS Journal

Embryological-Origin–Dependent Differences in Homeobox Expression in Adult Aorta

(2013) Laia Trigueros-Motos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383

(2013) Catherine M. Syddall et al.   PLoS Genetics

The Roles of Mechanical Stresses in the Pathogenesis of Osteoarthritis

(2013) Joseph A. Buckwalter et al.   Cartilage

Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow

(2012) Dorothy E. Pazin et al.   DEVELOPMENTAL DYNAMICS

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

Role of peripheral nerve fibres in acute and chronic inflammation in arthritis

(2012) Georg Pongratz et al.   Nature Reviews Rheumatology

Cartilage biology in osteoarthritis—lessons from developmental biology

(2011) Andrew A. Pitsillides et al.   Nature Reviews Rheumatology

Association between environmental factors and onset of psoriatic arthritis in patients with psoriasis

(2011) Lihi Eder et al.   ARTHRITIS CARE & RESEARCH

Revisiting the pathogenesis of podagra: why does gout target the foot?

(2011) Edward Roddy   Journal of Foot and Ankle Research

Erosive osteoarthritis: a current review of a clinical challenge

(2010) Sharon E. Banks   CLINICAL RHEUMATOLOGY

Homeobox genes d11–d13 and a13 control mouse autopod cortical bone and joint formation

(2010) Pablo Villavicencio-Lorini et al.   JOURNAL OF CLINICAL INVESTIGATION

Risk Factors for Axial Inflammatory Arthritis in Patients with Psoriatic Arthritis

(2010) V. CHANDRAN et al.   JOURNAL OF RHEUMATOLOGY

MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro

(2010) Y. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determinants of absence of osteoarthritis in old age

(2010) RJ Goekoop et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand

(2009) Evangelos Evangelou et al.   ARTHRITIS AND RHEUMATISM

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

(2009) Monica L. DeLay et al.   ARTHRITIS AND RHEUMATISM

Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women

(2009) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: A population-based study

(2009) Floranne C. Wilson et al.   ARTHRITIS AND RHEUMATISM

Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate

(2009) Joy Kahn et al.   DEVELOPMENTAL CELL

From HLA-B27 to spondyloarthritis: a journey through the ER

(2009) Robert A. Colbert et al.   IMMUNOLOGICAL REVIEWS

Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease

(2009) D McGonagle   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Vertebrate limb bud development: moving towards integrative analysis of organogenesis

(2009) Rolf Zeller et al.   NATURE REVIEWS GENETICS

The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee

(2009) A. J. MacGregor et al.   RHEUMATOLOGY

Epigenetic Temporal Control of Mouse Hox Genes in Vivo

(2009) N. Soshnikova et al.   SCIENCE

Regeneration, repair and remembering identity: the three Rs of Hox gene expression

(2009) Kevin C. Wang et al.   TRENDS IN CELL BIOLOGY

Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN

(2009) Petra Seemann et al.   PLoS Genetics

Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration

(2008) P. Leucht et al.   DEVELOPMENT

A dermal HOX transcriptional program regulates site-specific epidermal fate

(2008) J. L. Rinn et al.   GENES & DEVELOPMENT

Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness

(2008) T. Montavon et al.   GENES & DEVELOPMENT