Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Micro‐structural bone changes are associated with broad‐spectrum autoimmunity and predict the onset of rheumatoid arthritis

(2020) David Simon et al.   Arthritis & Rheumatology

Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis

(2020) Vugar Azizov et al.   Nature Communications

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

(2020) Narges Tajik et al.   Nature Communications

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

(2020) Stefano Alivernini et al.   NATURE MEDICINE

IL‐2 drives conversion of T follicular helper cells to T follicular regulatory cells through transcriptional regulation in systemic lupus erythematosus

(2020) He Hao et al.   Arthritis & Rheumatology

Prevotella copri in individuals at risk for rheumatoid arthritis

(2019) Deshire Alpizar-Rodriguez et al.   ANNALS OF THE RHEUMATIC DISEASES

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Potential Pharmacologic Targets for the Prevention of Rheumatoid Arthritis

(2019) John D. Isaacs et al.   CLINICAL THERAPEUTICS

Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study

(2019) Kenneth F. Baker et al.   JOURNAL OF AUTOIMMUNITY

Bromodomains: a new target class for drug development

(2019) Andrea G. Cochran et al.   NATURE REVIEWS DRUG DISCOVERY

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

The Role of Dietary Fiber in Rheumatoid Arthritis Patients: A Feasibility Study

(2019) Julian Häger et al.   Nutrients

Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1

(2019) Xumin Hu et al.   Molecular Therapy-Nucleic Acids

Histone demethylase JMJD3 regulates fibroblast-like synoviocyte-mediated proliferation and joint destruction in rheumatoid arthritis

(2018) Wanwan Jia et al.   FASEB JOURNAL

Regulatory T cells as a biomarker for response to adalimumab in rheumatoid arthritis

(2018) Dao X. Nguyen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T cells in autoimmune disease

(2018) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes

(2018) Rizi Ai et al.   Nature Communications

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

(2018) Emmanuel Karouzakis et al.   Scientific Reports

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi

(2018) Amila Suraweera et al.   Frontiers in Oncology

Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor

(2018) Caroline Chandra Tjin et al.   ACS Medicinal Chemistry Letters

Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study

(2018) Danielle M Gerlag et al.   ANNALS OF THE RHEUMATIC DISEASES

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

(2018) Michelle Rosenzwajg et al.   ANNALS OF THE RHEUMATIC DISEASES

Intensive therapy and remissions in rheumatoid arthritis: a systematic review

(2018) Catherine D. Hughes et al.   BMC MUSCULOSKELETAL DISORDERS

LncRNA HOTAIR alleviates rheumatoid arthritis by targeting miR-138 and inactivating NF-κB pathway

(2017) Hong-ju Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Effects of DMARDs on citrullinated peptide autoantibody levels in RA patients—A longitudinal analysis

(2017) Carolin Wunderlich et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

(2017) Mojca Frank-Bertoncelj et al.   Nature Communications

Sustained remission in rheumatoid arthritis: latest evidence and clinical considerations

(2017) Sofia Ajeganova et al.   Therapeutic Advances in Musculoskeletal Disease

Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs

(2016) Camille P Figueiredo et al.   ANNALS OF THE RHEUMATIC DISEASES

Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions

(2016) Georg Schett et al.   ANNALS OF THE RHEUMATIC DISEASES

Among human macrophages polarised to different phenotypes, the M-CSF-oriented cells present the highest pro-inflammatory response to the rheumatoid arthritis-specific immune complexes containing ACPA

(2016) Cyril Clavel et al.   ANNALS OF THE RHEUMATIC DISEASES

Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial

(2016) Johannes W J Bijlsma et al.   LANCET

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

(2016) René Pfeifle et al.   NATURE IMMUNOLOGY

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

(2016) Frieda A. Koopman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

(2016) Zhen Yang et al.   Science Translational Medicine

Predictors of Fatigue in Rheumatoid Arthritis Patients in Remission or in a Low Disease Activity State

(2016) Christin L. Olsen et al.   ARTHRITIS CARE & RESEARCH

In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage

(2016) Shiyu Zhou et al.   Arthritis & Rheumatology

β2-Adrenergic receptors in immunity and inflammation: Stressing NF-κB

(2015) Krzysztof Kolmus et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis

(2015) Gareth W. Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets

(2015) John W. Whitaker et al.   PLoS One

The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

(2015) Chiara Pastori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

(2015) Rizi Ai et al.   Arthritis & Rheumatology

Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

(2014) Linda M Hartkamp et al.   ANNALS OF THE RHEUMATIC DISEASES

Evaluating drug-free remission with abatacept in early rheumatoid arthritis: results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24 months, with a 12-month, double-blind treatment period

(2014) Paul Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Epigenome Analysis Reveals TBX5 as a Novel Transcription Factor Involved in the Activation of Rheumatoid Arthritis Synovial Fibroblasts

(2014) Emmanuel Karouzakis et al.   JOURNAL OF IMMUNOLOGY

Activation of Syk in Peripheral Blood B Cells in Patients With Rheumatoid Arthritis: A Potential Target for Abatacept Therapy

(2014) Shigeru Iwata et al.   Arthritis & Rheumatology

Does stress affect the joints? Daily stressors, stress vulnerability, immune and HPA axis activity, and short-term disease and symptom fluctuations in rheumatoid arthritis

(2013) Andrea W M Evers et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis

(2013) Mária Filková et al.   ANNALS OF THE RHEUMATIC DISEASES

Time trends in disease activity, response and remission rates in rheumatoid arthritis during the past decade: results from the NOR-DMARD study 2000–2010

(2013) Anna-Birgitte Aga et al.   ANNALS OF THE RHEUMATIC DISEASES

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

The protective effect of alcohol on developing rheumatoid arthritis: a systematic review and meta-analysis

(2013) I. C. Scott et al.   RHEUMATOLOGY

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Defining remission in rheumatoid arthritis

(2012) David Felson   ANNALS OF THE RHEUMATIC DISEASES

Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury

(2012) Markus Bosmann et al.   FASEB JOURNAL

Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Discontinuation of infliximab and potential predictors of persistent low disease activity in patients with early rheumatoid arthritis and disease activity score-steered therapy: subanalysis of the BeSt study

(2011) M. van den Broek et al.   ANNALS OF THE RHEUMATIC DISEASES

American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials

(2011) D. T. Felson et al.   ANNALS OF THE RHEUMATIC DISEASES

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Numbers of CD25+Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients

(2010) J. A. G. van Roon et al.   RHEUMATOLOGY

Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: Results from two large early arthritis cohorts

(2009) Diane van der Woude et al.   ARTHRITIS AND RHEUMATISM

Enhanced reactivity to pain in patients with rheumatoid arthritis

(2009) Robert R Edwards et al.   ARTHRITIS RESEARCH & THERAPY

A Key Claudin Extracellular Loop Domain is Critical for Epithelial Barrier Integrity

(2008) Randall J. Mrsny et al.   AMERICAN JOURNAL OF PATHOLOGY

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

(2008) D Makrygiannakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Disrupted brain-immune system-joint communication during experimental arthritis

(2008) Adriana del Rey et al.   ARTHRITIS AND RHEUMATISM

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

(2008) F. Flores-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse

(2007) C H Burgoyne et al.   ANNALS OF THE RHEUMATIC DISEASES