The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

(2013) Iain B McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis

(2013) Rachel Knevel et al.   ANNALS OF THE RHEUMATIC DISEASES

Epigenetic modifications in rheumatoid arthritis, a review

(2013) Kerstin Klein et al.   CURRENT OPINION IN PHARMACOLOGY

BET bromodomain inhibition suppresses TH17-mediated pathology

(2013) Deanna A. Mele et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

(2013) Dominique Baeten et al.   LANCET

The ascent of acetylation in the epigenetics of rheumatoid arthritis

(2013) Aleksander M. Grabiec et al.   Nature Reviews Rheumatology

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor Necrosis Factor α-Induced MicroRNA-18a Activates Rheumatoid Arthritis Synovial Fibroblasts Through a Feedback Loop in NF-κB Signaling

(2012) Michelle Trenkmann et al.   ARTHRITIS AND RHEUMATISM

The bromodomain interaction module

(2012) Panagis Filippakopoulos et al.   FEBS LETTERS

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Place your BETs: the therapeutic potential of bromodomains

(2012) R.K. Prinjha et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

(2011) Aleksander M Grabiec et al.   ANNALS OF THE RHEUMATIC DISEASES

Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients

(2011) Justin Gillespie et al.   ARTHRITIS AND RHEUMATISM

Inflammatory memories: Is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?

(2011) Caroline Ospelt et al.   AUTOIMMUNITY REVIEWS

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Migratory potential of rheumatoid arthritis synovial fibroblasts: Additional perspectives

(2010) Elena Neumann et al.   CELL CYCLE

Histone Deacetylase Inhibitors Suppress Inflammatory Activation of Rheumatoid Arthritis Patient Synovial Macrophages and Tissue

(2010) Aleksander M. Grabiec et al.   JOURNAL OF IMMUNOLOGY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts

(2009) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

(2009) John A. Hamilton et al.   ARTHRITIS AND RHEUMATISM

Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis

(2009) Hiba Mahdi et al.   NATURE GENETICS

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA

(2008) B. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY