TSPO imaging in animal models of brain diseases

Astroglial Connexin 43 Deficiency Protects against LPS-Induced Neuroinflammation: A TSPO Brain µPET Study with [18F]FEPPA

(2020) Nicolas Vignal et al.   Cells

[18F]-DPA-714 PET as a specific in vivo marker of early microglial activation in a rat model of progressive dopaminergic degeneration

(2020) Tatiana Rodríguez-Chinchilla et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Reliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio

(2020) Ralph Buchert et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis

(2020) A. R. Coda et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation

(2020) Diego Cabezudo et al.   Frontiers in Neuroscience

Quantification of [11C]PBR28 data after systemic lipopolysaccharide challenge

(2020) Eric A. Woodcock et al.   EJNMMI Research

Translation Imaging in Parkinson’s Disease: Focus on Neuroinflammation

(2020) Sara Belloli et al.   Frontiers in Aging Neuroscience

Peripheral benzodiazepine receptor/18 kDa translocator protein positron emission tomography imaging in a rat model of acute brain injury

(2020) Masahiko Nomura et al.   ANNALS OF NUCLEAR MEDICINE

TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis

(2020) Stefanie Völk et al.   CLINICAL NUCLEAR MEDICINE

Dual PET Imaging of an H3K27M-Mutant Glioma With 18F-GE-180 and 18F-FET PET

(2020) Franziska J. Vettermann et al.   CLINICAL NUCLEAR MEDICINE

Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series

(2020) Valerie Joers et al.   NEUROBIOLOGY OF DISEASE

PET Imaging for Dynamically Monitoring Neuroinflammation in APP/PS1 Mouse Model Using [18F]DPA714

(2020) Wei Hu et al.   Frontiers in Neuroscience

TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat

(2020) Nassir U. Al-Khishman et al.   EJNMMI Research

Microglial Activation in the Right Amygdala-Entorhinal-Hippocampal Complex is Associated with Preserved Spatial Learning in App mice

(2020) Gloria Biechele et al.   NEUROIMAGE

PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation

(2019) Tamara Berdyyeva et al.   MOLECULAR IMAGING AND BIOLOGY

Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models

(2019) Anne Nack et al.   Cells

Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [18F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter

(2019) Sujata Sridharan et al.   MOLECULAR IMAGING AND BIOLOGY

Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease

(2019) Alexander Levit et al.   BRAIN BEHAVIOR AND IMMUNITY

Comparison of high and low molar activity TSPO tracer [18F]F-DPA in a mouse model of Alzheimer’s disease

(2019) Thomas Keller et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation

(2019) S. K. Vainio et al.   EJNMMI Research

Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamide

(2019) Van Hieu Tran et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding

(2019) Benjamin B Tournier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model

(2019) Christian Sacher et al.   JOURNAL OF NUCLEAR MEDICINE

TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlative 18F-GE-180 PET study

(2019) M. Unterrainer et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Questions and (some) answers on reactive astrocytes

(2019) Carole Escartin et al.   GLIA

Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia

(2019) Maria Pannell et al.   GLIA

Development of a novel radioligand for imaging 18-kD translocator protein (TSPO) in a rat model of Parkinson’s disease

(2019) Chun-Yi Wu et al.   BMC MEDICAL IMAGING

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

(2019) Melissa Crabbé et al.   Frontiers in Neuroscience

Temporal changes in neuroinflammation and brain glucose metabolism in a rat model of viral vector-induced α-synucleinopathy

(2019) Melissa Crabbé et al.   EXPERIMENTAL NEUROLOGY

The endotoxin hypothesis of neurodegeneration

(2019) Guy C. Brown   Journal of Neuroinflammation

Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study

(2019) Satoru Yamagishi et al.   Journal of Neuroinflammation

Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer’s-like transgenic mice

(2019) Bin Liu et al.   Scientific Reports

Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge

(2019) Valentina Murtaj et al.   Frontiers in Aging Neuroscience

Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats

(2019) Petri Elo et al.   Journal of Neuroinflammation

Laquinimod ameliorates secondary brain inflammation

(2019) Julia Nedelcu et al.   NEUROBIOLOGY OF DISEASE

Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI

(2019) Marius de Groot et al.   EJNMMI Research

Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation

(2018) Byung Seok Moon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation of the novel TSPO radiotracer 2-(7-butyl-2-(4-(2-([ 18 F]fluoroethoxy)phenyl)-5-methylpyrazolo[1,5- a ]pyrimidin-3-yl)- N , N -diethylacetamide in a preclinical model of neuroinflammation

(2018) Dewei Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs

(2018) Thea P. Lillethorup et al.   EXPERIMENTAL NEUROLOGY

TSPO–PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75NTR ligand LM11A-31

(2018) Danielle A Simmons et al.   HUMAN MOLECULAR GENETICS

18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis

(2018) Sara Belloli et al.   Journal of Neuroinflammation

11C-DPA-713 versus18F-GE-180: A preclinical comparison of TSPO-PET tracers to visualize acute and chronic neuroinflammation in a mouse model of ischemic stroke

(2018) Aisling Chaney et al.   JOURNAL OF NUCLEAR MEDICINE

Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington’s disease

(2018) Surekha Ramachandran et al.   METABOLIC BRAIN DISEASE

[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model

(2018) Nicolas Vignal et al.   MOLECULES

Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure

(2018) Zhi Zhang et al.   NEUROBIOLOGY OF DISEASE

Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry

(2018) Fiona Henderson et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

In vivo Quantification of Glial Activation in Minipigs Overexpressing human α-synuclein

(2018) Thea Pinholt Lillethorup et al.   SYNAPSE

Brain Region-dependent Heterogeneity and Dose-dependent Difference in Transient Microglia Population Increase during Lipopolysaccharide-induced Inflammation

(2018) Eriko Furube et al.   Scientific Reports

Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide

(2018) Yazmin M. Flores-Martinez et al.   Journal of Immunology Research

[18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia

(2018) Chengbo Tan et al.   EJNMMI Research

Detection of neuroinflammation before selective neuronal loss appearance after mild focal ischemia using [18F]DPA-714 imaging

(2018) Natsumi Miyajima et al.   EJNMMI Research

[18F]DAA1106: Automated radiosynthesis using spirocyclic iodonium ylide and preclinical evaluation for positron emission tomography imaging of translocator protein (18 kDa)

(2018) Katsushi Kumata et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel potential pyrazolopyrimidine based translocator protein ligands for the evaluation of neuroinflammation with PET

(2018) Young-Do Kwon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts

(2018) Nina Weishaupt et al.   Journal of Neuroinflammation

Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs

(2018) Charlotte de Lange et al.   NUCLEAR MEDICINE AND BIOLOGY

Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain

(2018) Masayuki Fujinaga et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs

(2018) Thea P. Lillethorup et al.   Scientific Reports

Translocator Protein (18 kDa) Mapping with [ 125 I]-CLINDE in the Quinolinic Acid Rat Model of Excitotoxicity: A Longitudinal Comparison with Microglial Activation, Astrogliosis, and Neuronal Death

(2018) Nicolas Arlicot et al.   Molecular Imaging

In vivo molecular imaging of neuroinflammation in Alzheimer's disease

(2018) Aisling Chaney et al.   JOURNAL OF NEUROCHEMISTRY

TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer’s disease

(2018) Benjamin B. Tournier et al.   NEUROBIOLOGY OF DISEASE

Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches

(2018) Steven Vetel et al.   SYNAPSE

Single Inflammatory Trigger Leads to Neuroinflammation in LRRK2 Rodent Model without Degeneration of Dopaminergic Neurons

(2018) Anna Schildt et al.   Journal of Parkinsons Disease

Volume-of-interest-based supervised cluster analysis for pseudo-reference region selection in [18F]DPA-714 PET imaging of the rat brain

(2018) Igor Fagner Vieira et al.   EJNMMI Research

PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats

(2017) Geraldine Pottier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

(2017) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation

(2017) Lu Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a 18F-Labeled Radiotracer with Improved Brain Kinetics for Positron Emission Tomography Imaging of Translocator Protein (18 kDa) in Ischemic Brain and Glioma

(2017) Masayuki Fujinaga et al.   JOURNAL OF MEDICINAL CHEMISTRY

Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe ×PS1Δe9 transgenic mouse model of Alzheimer's disease

(2017) Aisling Chaney et al.   JOURNAL OF NEUROCHEMISTRY

In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study

(2017) Teruyo Hosoya et al.   Journal of Neuroinflammation

Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease

(2017) Francisco R. López-Picón et al.   JOURNAL OF NUCLEAR MEDICINE

Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats

(2017) Thomas Keller et al.   MOLECULAR IMAGING AND BIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice

(2017) Sara Belloli et al.   NEUROBIOLOGY OF AGING

Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates

(2017) Ansel T. Hillmer et al.   EJNMMI Research

Evaluation of the novel TSPO radiotracer [18F] VUIIS1008 in a preclinical model of cerebral ischemia in rats

(2017) Krishna R. Pulagam et al.   EJNMMI Research

Lipopolysaccharide enters the rat brain by a lipoprotein-mediated transport mechanism in physiological conditions

(2017) Alejandra Vargas-Caraveo et al.   Scientific Reports

F-18 FDG PET/CT imaging of cardiac and vascular inflammation and infection

(2016) Ismaheel Lawal et al.   BRITISH MEDICAL BULLETIN

Complex and Differential Glial Responses in Alzheimers Disease and Ageing

(2016) José J. Rodríguez et al.   Current Alzheimer Research

6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis

(2016) Inga B. Fricke et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transcranial direct current stimulation accelerates recovery of function, induces neurogenesis and recruits oligodendrocyte precursors in a rat model of stroke

(2016) Ramona Braun et al.   EXPERIMENTAL NEUROLOGY

Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

(2016) Ana Moraga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats

(2016) Sujata Sridharan et al.   MOLECULAR IMAGING AND BIOLOGY

Synthesis and Preclinical Evaluation of Folate-NOTA-Al18F for PET Imaging of Folate-Receptor-Positive Tumors

(2016) Qingshou Chen et al.   MOLECULAR PHARMACEUTICS

Glucose consumption of inflammatory cells masks metabolic deficits in the brain

(2016) Heiko Backes et al.   NEUROIMAGE

Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT Imaging of Intracranial Malignancies

(2016) Erik S. Mittra et al.   PLoS One

PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats

(2016) Maria Domercq et al.   Theranostics

LPS and neuroinflammation: a matter of timing

(2016) Patricia C. Lopes   INFLAMMOPHARMACOLOGY

Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [18F]DPA-714 PET Imaging

(2016) Clément Thomas et al.   Molecular Imaging

Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195

(2015) Kentaro Hatano et al.   ANNALS OF NUCLEAR MEDICINE

Acute neuroinflammation in a clinically relevant focal cortical ischemic stroke model in rat: longitudinal positron emission tomography and immunofluorescent tracking

(2015) Miklós Tóth et al.   Brain Structure & Function

Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [18F]DPA-714 PET

(2015) Dieter Ory et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo imaging of system xc- as a novel approach to monitor multiple sclerosis

(2015) Abraham Martín et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

[11C]PBR28 PET Imaging is Sensitive to Neuroinflammation in the Aged Rat

(2015) Matthew D Walker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Multimodal Imaging Reveals Temporal and Spatial Microglia and Matrix Metalloproteinase Activity after Experimental Stroke

(2015) Bastian Zinnhardt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

In VivoPET Imaging of the α4β2 Nicotinic Acetylcholine Receptor As a Marker for Brain Inflammation after Cerebral Ischemia

(2015) Abraham Martín et al.   JOURNAL OF NEUROSCIENCE

Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study

(2015) Sophie Sérrière et al.   NEUROBIOLOGY OF AGING

In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke

(2015) H.L. Walter et al.   NEUROSCIENCE

PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide

(2015) Dieter Ory et al.   NUCLEAR MEDICINE AND BIOLOGY

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

(2015) Christine M. Sandiego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy

(2015) Xiao-Jiang Li et al.   Drug Design Development and Therapy

[18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain

(2015) Anjani K. Tiwari et al.   Theranostics

PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2

(2014) Kai-Yvonne Shivers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

[18F]Fluoromethyl-PBR28 as a Potential Radiotracer for TSPO: Preclinical Comparison with [11C]PBR28 in a Rat Model of Neuroinflammation

(2014) Byung Seok Moon et al.   BIOCONJUGATE CHEMISTRY

[18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain

(2014) S. Lavisse et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke

(2014) Hervé Boutin et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

(2014) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Detection of Microglial Activation in an Acute Model of Neuroinflammation Using PET and Radiotracers 11C-(R)-PK11195 and 18F-GE-180

(2014) A. M. Dickens et al.   JOURNAL OF NUCLEAR MEDICINE

In Vivo SPECT Imaging of Amyloid-  Deposition with Radioiodinated Imidazo[1,2-a]Pyridine Derivative DRM106 in a Mouse Model of Alzheimer's Disease

(2014) C.-J. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

PET imaging of glucose metabolism, neuroinflammation and demyelination in the lysolecithin rat model for multiple sclerosis

(2014) Daniele de Paula Faria et al.   Multiple Sclerosis Journal

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Endotoxin-induced experimental systemic inflammation in humans: A model to disentangle immune-to-brain communication

(2013) Manfred Schedlowski et al.   BRAIN BEHAVIOR AND IMMUNITY

Longitudinal Assessment of Cerebral  -Amyloid Deposition in Mice Overexpressing Swedish Mutant  -Amyloid Precursor Protein Using 18F-Florbetaben PET

(2013) A. Rominger et al.   JOURNAL OF NUCLEAR MEDICINE

Central Nervous System Expression and PET Imaging of the Translocator Protein in Relapsing-Remitting Experimental Autoimmune Encephalomyelitis

(2013) F. Mattner et al.   JOURNAL OF NUCLEAR MEDICINE

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats

(2013) Hervé Boutin et al.   PLoS One

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination

(2012) Wolfgang Brück et al.   ACTA NEUROPATHOLOGICA

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates

(2012) Jonas Hannestad et al.   NEUROIMAGE

Longitudinal and parallel monitoring of neuroinflammation and neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease

(2012) Serge Maia et al.   SYNAPSE

Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

(2011) Katherine R. Leaver et al.   ACS Chemical Neuroscience

Modulation of Autoimmune Demyelination by Laquinimod via Induction of Brain-Derived Neurotrophic Factor

(2011) Jan Thöne et al.   AMERICAN JOURNAL OF PATHOLOGY

The MMP inhibitor (R)-2-(N-benzyl-4-(2-[18F]fluoroethoxy)phenylsulphonamido)-N-hydroxy-3-methylbutanamide: Improved precursor synthesis and fully automated radiosynthesis

(2011) Stefan Wagner et al.   APPLIED RADIATION AND ISOTOPES

Assessing the contribution of inflammation in models of Alzheimer's disease: Figure 1

(2011) Hannah Johnston et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

11C-(R)-PK11195 PET Imaging of Microglial Activation and Response to Minocycline in Zymosan-Treated Rats

(2011) A. K. Converse et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer

(2011) Nele Evens et al.   NUCLEAR MEDICINE AND BIOLOGY

Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [11C]PK11195 in rats

(2010) Fumitaka Ito et al.   ANNALS OF NUCLEAR MEDICINE

A novel PET marker for in vivo quantification of myelination

(2010) Chunying Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat

(2010) S. Walsh et al.   NEUROSCIENCE

Evaluation of the PBR/TSPO Radioligand [18F]DPA-714 in a Rat Model of Focal Cerebral Ischemia

(2009) Abraham Martín et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Striatal Neuroinflammation Promotes Parkinsonism in Rats

(2009) Dong-Young Choi et al.   PLoS One

Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation

(2008) Nicolas Arlicot et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

VMAT2 and dopamine neuron loss in a primate model of Parkinson’s disease

(2008) Ming-Kai Chen et al.   JOURNAL OF NEUROCHEMISTRY

Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism

(2008) Christopher C Rowe et al.   LANCET NEUROLOGY