Single Inflammatory Trigger Leads to Neuroinflammation in LRRK2 Rodent Model without Degeneration of Dopaminergic Neurons

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

(2017) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROIMMUNOLOGY

LRRK2BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function

(2016) Max Sloan et al.   HUMAN MOLECULAR GENETICS

[11C]PBR28 PET Imaging is Sensitive to Neuroinflammation in the Aged Rat

(2015) Matthew D Walker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats

(2015) Jang-Won Lee et al.   NEUROBIOLOGY OF AGING

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

(2015) Christine M. Sandiego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 pathobiology in Parkinson's disease

(2014) Ian Martin et al.   JOURNAL OF NEUROCHEMISTRY

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

(2014) Isabella Russo et al.   Journal of Neuroinflammation

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

(2014) Francesco Longo et al.   NEUROBIOLOGY OF DISEASE

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multiple Intranigral Unilateral LPS Infusion Protocol Generates a Persistent Cognitive Impairment without Cumulative Dopaminergic Impairment

(2013) Ana Delattre et al.   CNS & Neurological Disorders-Drug Targets

Microglia, Amyloid and Glucose Metabolism in Parkinson’s Disease with and without Dementia

(2013) Paul Edison et al.   NEUROPSYCHOPHARMACOLOGY

Diffusion-weighted imaging and its relationship to microglial activation in parkinsonian syndromes

(2013) Christopher Kobylecki et al.   PARKINSONISM & RELATED DISORDERS

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

(2012) Deirdre B. Hoban et al.   BRAIN BEHAVIOR AND IMMUNITY

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

(2012) C-Y Chen et al.   CELL DEATH AND DIFFERENTIATION

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

(2012) Daniel C. Berwick et al.   HUMAN MOLECULAR GENETICS

In-vivo Measurement of LDOPA Uptake, Dopamine Reserve and Turnover in the Rat Brain Using [18F]FDOPA PET

(2012) Matthew D Walker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates

(2012) Jonas Hannestad et al.   NEUROIMAGE

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

Use of [18F]FDOPA-PET for in vivo evaluation of dopaminergic dysfunction in unilaterally 6-OHDA-lesioned rats

(2011) Kiyoshi Kyono et al.   EJNMMI Research

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Dopamine turnover increases in asymptomatic LRRK2 mutations carriers

(2010) Vesna Sossi et al.   MOVEMENT DISORDERS

Microglial activation in healthy aging

(2010) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

(2009) A.L. Bartels et al.   PARKINSONISM & RELATED DISORDERS

Positron emission tomography kinetic modeling algorithms for small animal dopaminergic system imaging

(2009) Geoffrey J. Topping et al.   SYNAPSE

Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

(2008) Colm Cunningham et al.   BIOLOGICAL PSYCHIATRY

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY