Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models

TSPO PET with [18F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing–remitting multiple sclerosis

(2018) Marcus Unterrainer et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

TSPO regulation in reactive gliotic diseases

(2018) Adam M. McNeela et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus

(2018) Nehal Narayan et al.   JOURNAL OF NUCLEAR MEDICINE

Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction

(2018) James T. Thackeray et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models

(2018) Stella Nyamoya et al.   MOLECULAR NEUROBIOLOGY

Coupling between physiological TSPO expression in brain and myocardium allows stabilization of late-phase cerebral [ 18 F]GE180 PET quantification

(2018) Maximilian Deussing et al.   NEUROIMAGE

Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances

(2018) Daisuke Fukudome et al.   SCHIZOPHRENIA RESEARCH

Age Influences Microglial Activation After Cuprizone-Induced Demyelination

(2018) Barbara Klein et al.   Frontiers in Aging Neuroscience

Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

(2018) Tanja Blume et al.   Journal of Neuroinflammation

Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression

(2017) Bernhard Josef Rüther et al.   GLIA

An Updated View of Translocator Protein (TSPO)

(2017) Nunzio Denora et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis

(2017) Nicolás Fernández Hurst et al.   JOURNAL OF NEUROIMMUNOLOGY

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function

(2017) Daniel Ontaneda et al.   LANCET

Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia

(2017) T Notter et al.   MOLECULAR PSYCHIATRY

TSPO imaging using the novel PET ligand [18F]GE-180: quantification approaches in patients with multiple sclerosis

(2017) Lena Vomacka et al.   EJNMMI Research

Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach

(2016) Katharina Marie Höflich et al.   BRAIN RESEARCH

Novel MRI and PET markers of neuroinflammation in multiple sclerosis

(2016) Marloes Hagens et al.   CURRENT OPINION IN NEUROLOGY

Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the Forebrain

(2016) M. Scheld et al.   JOURNAL OF NEUROSCIENCE

18-kDa translocator protein ligand 18F-FEMPA: Biodistribution and uptake into atherosclerotic plaques in mice

(2016) Sanna Hellberg et al.   JOURNAL OF NUCLEAR CARDIOLOGY

Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study

(2016) M. Brendel et al.   JOURNAL OF NUCLEAR MEDICINE

Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein

(2016) Z. Fan et al.   JOURNAL OF NUCLEAR MEDICINE

Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [18F]-Florbetaben PET Quantitation in Alzheimer's Model Mice

(2016) Felix Overhoff et al.   Frontiers in Neuroscience

Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage

(2015) Junli Liu et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo PET Imaging Demonstrates Diminished Microglial Activation After Fingolimod Treatment in an Animal Model of Multiple Sclerosis

(2015) L. Airas et al.   JOURNAL OF NUCLEAR MEDICINE

The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination

(2014) A Slowik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response

(2014) Agnieszka Wlodarczyk et al.   Journal of Neuroinflammation

Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons

(2014) Nobuhiko Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The development of an automated and GMP compliant FASTlab™ Synthesis of [18F]GE-180; a radiotracer for imaging translocator protein (TSPO)

(2013) Torild Wickstrøm et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Central Nervous System Expression and PET Imaging of the Translocator Protein in Relapsing-Remitting Experimental Autoimmune Encephalomyelitis

(2013) F. Mattner et al.   JOURNAL OF NUCLEAR MEDICINE

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

(2013) Yichuan Xiao et al.   NATURE MEDICINE

Intense Inflammation and Nerve Damage in Early Multiple Sclerosis Subsides at Older Age: A Reflection by Cerebrospinal Fluid Biomarkers

(2013) Mohsen Khademi et al.   PLoS One

Pathology of Multiple Sclerosis

(2012) Markus Kipp et al.   CNS & Neurological Disorders-Drug Targets

Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions

(2012) Tim Clarner et al.   GLIA

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18 kDa Translocator Protein Radioligand [18F]DPA-714

(2012) G. Abourbeh et al.   JOURNAL OF NEUROSCIENCE

Cholinergic imbalance in the multiple sclerosis hippocampus

(2011) Evert-Jan Kooi et al.   ACTA NEUROPATHOLOGICA

Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis

(2011) Jessica L. Zambonin et al.   BRAIN

Evaluation of [123I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation

(2011) Filomena Mattner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

ADAM12 is expressed by astrocytes during experimental demyelination

(2010) Fabian Baertling et al.   BRAIN RESEARCH

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Mitochondrial changes within axons in multiple sclerosis

(2009) D. J. Mahad et al.   BRAIN

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker

(2009) William C. Kreisl et al.   NEUROIMAGE

Caudate nuclei volume, diffusion tensor metrics, and T2relaxation in healthy adults and relapsing-remitting multiple sclerosis patients: Implications for understanding gray matter degeneration

(2008) Khader M. Hasan et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

MHC class II exacerbates demyelination in vivo independently of T cells

(2008) Meenaxi M. Hiremath et al.   JOURNAL OF NEUROIMMUNOLOGY

The place of conventional MRI and newly emerging MRI techniques in monitoring different aspects of treatment outcome

(2008) Robert Zivadinov et al.   JOURNAL OF NEUROLOGY

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

(2008) M. Cosenza-Nashat et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY