[11C]PBR28 PET Imaging is Sensitive to Neuroinflammation in the Aged Rat

Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study

(2014) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

(2013) I. Suridjan et al.   NEUROIMAGE

Litter size, age-related memory impairments, and microglial changes in rat dentate gyrus: Stereological analysis and three dimensional morphometry

(2013) L.C. Viana et al.   NEUROSCIENCE

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats

(2013) Hervé Boutin et al.   PLoS One

Fully automated radiosynthesis of [11C]PBR28, a radiopharmaceutical for the translocator protein (TSPO) 18kDa, using a GE TRACERlab FXC-Pro

(2012) Raphaël Hoareau et al.   APPLIED RADIATION AND ISOTOPES

Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET

(2012) Ajay Kumar et al.   Journal of Neuroinflammation

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity

(2012) F. Gillardon et al.   NEUROSCIENCE

Longitudinal and parallel monitoring of neuroinflammation and neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease

(2012) Serge Maia et al.   SYNAPSE

Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

(2011) Katherine R. Leaver et al.   ACS Chemical Neuroscience

Brain inflammation is induced by co-morbidities and risk factors for stroke

(2011) Caroline Drake et al.   BRAIN BEHAVIOR AND IMMUNITY

Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences

(2011) Adam D. Hart et al.   BRAIN BEHAVIOR AND IMMUNITY

Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine

(2011) Balázs Gulyás et al.   NEUROIMAGE

Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [11C]PK11195 in rats

(2010) Fumitaka Ito et al.   ANNALS OF NUCLEAR MEDICINE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Development and validation of a variance model for dynamic PET: uses in fitting kinetic data and optimizing the injected activity

(2010) M D Walker et al.   PHYSICS IN MEDICINE AND BIOLOGY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET

(2008) Sriram Venneti et al.   NEUROBIOLOGY OF AGING

Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors

(2008) Alan A. Wilson et al.   NUCLEAR MEDICINE AND BIOLOGY

Synthesis and Evaluation in Monkey of Two Sensitive11C-Labeled Aryloxyanilide Ligands for Imaging Brain Peripheral Benzodiazepine Receptors In Vivo

(2007) Emmanuelle Briard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors

(2007) Masao Imaizumi et al.   NEUROIMAGE