Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches

Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease

(2018) Avtar K. Handa et al.   Frontiers in Chemistry

Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling

(2017) Blandine Madji Hounoum et al.   GLIA

Developmental regulation and localization of carnitine palmitoyltransferases (CPTs) in rat brain

(2017) Jennifer N. Jernberg et al.   JOURNAL OF NEUROCHEMISTRY

Workflow methodology for rat brain metabolome exploration using NMR, LC–MS and GC–MS analytical platforms

(2017) Binta Diémé et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain

(2017) Gustavo C. Ferreira et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model

(2017) Laura Foucault-Fruchard et al.   NEUROSCIENCE

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

(2017) Marlen Knobloch et al.   Cell Reports

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Are rodent models of Parkinson’s disease behaving as they should?

(2017) Siv Vingill et al.   BEHAVIOURAL BRAIN RESEARCH

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis

(2016) Inga B. Fricke et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

(2016) Sandra M. Rocha et al.   Journal of Neuroinflammation

Characterization of a new low-dose 6-hydroxydopamine model of Parkinson's disease in rat

(2016) Anna-Maija Penttinen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Non-motor symptoms in Parkinson's disease

(2016) Ronald F. Pfeiffer   PARKINSONISM & RELATED DISORDERS

18F-DPA-714 PET Imaging for Detecting Neuroinflammation in Rats with Chronic Hepatic Encephalopathy

(2016) Xiang Kong et al.   Theranostics

Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism

(2016) Zhigang Xie et al.   Cell Reports

Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease

(2016) Juhyun Song et al.   Frontiers in Aging Neuroscience

Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [18F]DPA-714 PET Imaging

(2016) Clément Thomas et al.   Molecular Imaging

Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [18F]DPA-714 PET

(2015) Dieter Ory et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Efficient tritiation of the translocator protein (18 kDa) selective ligand DPA-714

(2015) Annelaure Damont et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

NMR-Based Metabolomics Reveal a Recovery from Metabolic Changes in the Striatum of 6-OHDA-Induced Rats Treated with Basic Fibroblast Growth Factor

(2015) Hong Zheng et al.   MOLECULAR NEUROBIOLOGY

Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: A longitudinal in-vivo study

(2015) Francisco Molinet-Dronda et al.   NEUROBIOLOGY OF DISEASE

Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-l-carnitine

(2015) S. Sarkar et al.   NEUROSCIENCE LETTERS

Animal models of Parkinson's disease: An updated overview

(2015) P. Gubellini et al.   REVUE NEUROLOGIQUE

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease

(2014) Shane Grealish et al.   Cell Stem Cell

Emerging therapies for Parkinson's disease: From bench to bedside

(2014) F.I. Tarazi et al.   PHARMACOLOGY & THERAPEUTICS

Evidence of Inflammatory System Involvement in Parkinson’s Disease

(2014) Yinxia Chao et al.   Biomed Research International

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nigrostriatal Dopamine Terminal Imaging with Dopamine Transporter SPECT: An Update

(2013) K. Tatsch et al.   JOURNAL OF NUCLEAR MEDICINE

In vivo PET quantification of the dopamine transporter in rat brain with [18F]LBT-999

(2013) Sophie Sérrière et al.   NUCLEAR MEDICINE AND BIOLOGY

An Overview of PET Neuroimaging

(2013) Ilya Nasrallah et al.   SEMINARS IN NUCLEAR MEDICINE

Metabolic Changes Detected by Ex Vivo High Resolution 1H NMR Spectroscopy in the Striatum of 6-OHDA-Induced Parkinson’s Rat

(2012) Hong-Chang Gao et al.   MOLECULAR NEUROBIOLOGY

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

Functional neuroimaging of the 6-OHDA lesion rat model of Parkinson's disease

(2012) Dong Pyo Jang et al.   NEUROSCIENCE LETTERS

Amphetamine-induced rotation and l-DOPA-induced dyskinesia in the rat 6-OHDA model: A correlation study

(2012) Elisabetta Tronci et al.   NEUROSCIENCE RESEARCH

Treatment with a Substance P Receptor Antagonist Is Neuroprotective in the Intrastriatal 6-Hydroxydopamine Model of Early Parkinson's Disease

(2012) Emma Thornton et al.   PLoS One

Longitudinal and parallel monitoring of neuroinflammation and neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease

(2012) Serge Maia et al.   SYNAPSE

Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease

(2011) Kelly E. Glajch et al.   BEHAVIOURAL BRAIN RESEARCH

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Imaging biomarkers in Parkinson's disease

(2011) David J. Brooks et al.   PROGRESS IN NEUROBIOLOGY

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Polyamine pathway contributes to the pathogenesis of Parkinson disease

(2010) N. M. Lewandowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases

(2008) Avik Roy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of l-carnitine

(2008) Daniela Silva-Adaya et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The 6-hydroxydopamine model: News from the past

(2008) Fabio Blandini et al.   PARKINSONISM & RELATED DISORDERS

Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair

(2008) Ming-Kai Chen et al.   PHARMACOLOGY & THERAPEUTICS