Article
Radiology, Nuclear Medicine & Medical Imaging
Nisha K. Ramakrishnan, Matthew Hird, Stephen Thompson, David J. Williamson, Luxi Qiao, David R. Owen, Allen F. Brooks, Peter J. H. Scott, Sergio Bacallado, John T. O'Brien, Franklin Aigbirhio
Summary: This study evaluated the two enantiomers of [F-18]GE387, showing that (S)-[F-18]GE387 has favorable kinetics in healthy subjects and can distinguish inflamed brain regions in neuroinflammation models, while also demonstrating low sensitivity to TSPO polymorphism in human brain tissue.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Medicinal
Chunmei Lu, Xiuting Wang, Qiqi Wang, Lixia Zhang, Jianguo Lin, Ling Qiu
Summary: Legumain is overexpressed in several cancers and serves as an important biomarker for cancer diagnosis. In this study, a novel radioactive tracer [F-18]SF-AAN was designed and synthesized for positron emission tomography (PET) imaging, targeting legumain. The tracer showed specificity in detecting legumain activity in vitro and in vivo, making it a promising tool for the diagnosis of legumain-related diseases.
Article
Immunology
Kuriko Kagitani-Shimono, Hiroki Kato, Ryoko Kuwayama, Koji Tominaga, Shin Nabatame, Haruhiko Kishima, Jun Hatazawa, Masako Taniike
Summary: Neuroinflammation, visualized using translocator protein positron emission tomography with [C-11] DPA713, was found to be sensitive in identifying epileptic foci in child-onset focal epilepsy. The inflammation was implicated in the pathophysiology of epileptic foci caused by various etiologies, indicating a need for further research in diagnostic tools for identifying focal epileptogenic zones.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Guolong Huang, Xiaolei Lu, Yifan Qiu, Lei Bi, Peizhen Ye, Min Yang, Yanfang Shen, Hongjun Jin, Junbin Han
Summary: A novel P2X7R targeting radiotracer was synthesized and proved to stably retain and target P2X7R in vivo without defluorination in major organs. It shows potential as a promising PET radioligand for clinical translation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Robert K. Doot, Anthony J. Young, Ilya M. Nasrallah, Reagan R. Wetherill, Andrew Siderowf, Robert H. Mach, Jacob G. Dubroff
Summary: Neuroinflammation is an important factor in neurodegenerative diseases and is mediated by microglia. This study used [F-18]NOS PET imaging to measure neuroinflammation in idiopathic Parkinson's disease patients and found increased oxidative stress as a marker of inflammation in early-stage disease.
Article
Oncology
Xiufang Qiu, Haixia Wu, Ting Xu, Shihan Xie, Ziqing You, Yixin Hu, Yinghong Zheng, Zewei Liang, Chaoxiong Huang, Li Yi, Li Li, Jing Liu, Zhaodong Fei, Chuanben Chen
Summary: This study aimed to reassess the clinical significance of standardized uptake values (SUVs) in nasopharyngeal carcinoma (NPC) on F-18-fluorodeoxyglucose (F-18-FDG) positron-emission tomography (PET). The results showed that high SUVs were associated with cancer recurrence, and the SUVmax-NTR ratio was identified as a potential prognostic factor.
Review
Clinical Neurology
Peng-Fei Zhang, Fan Gao
Summary: Neuroinflammation may play a role in the progression of Parkinson's disease, as evidenced by elevated TSPO levels in various brain regions of PD patients compared to healthy controls. The involvement of neuroinflammation in PD pathogenesis remains ambiguous, with contrasting outcomes depending on the ligand used in the study.
JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
R. Gallicchio, A. Nardelli, G. Calice, A. Guarini, G. Guglielmi, G. Storto
Summary: This study evaluated the prognostic significance of combined use of FDG and FLT PET/CT in MM patients, showing that PET/CT can predict patient prognosis and that FDG+; FLT- patients have better EFS compared to other groups.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jennifer M. Coughlin, Stephanie Slania, Yong Du, Laura K. Shinehouse, Mary Katherine Brosnan, Babak Behnam Azad, Daniel P. Holt, Hong Fan, Wojciech G. Lesniak, Il Minn, Steven P. Rowe, Robert F. Dannals, Andrew G. Horti, Martin G. Pomper
Summary: The study demonstrated that [F-18]FNDP PET can be used to study sEH in the human brain. Results showed that [F-18]FNDP had stable and reliable performance in the brains of healthy adults.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Amanda Nguyen, Felipe Martinez, Ba D. Nguyen
Summary: This case report presents chest wall keloids detected on F-18-piflufolastat PET/CT during the evaluation of prostate cancer recurrence.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Review
Pharmacology & Pharmacy
Lingling Zhang, Kuan Hu, Tuo Shao, Lu Hou, Shaojuan Zhang, Weijian Ye, Lee Josephson, Jeffrey H. Meyer, Ming-Rong Zhang, Neil Vasdev, Jinghao Wang, Hao Xu, Lu Wang, Steven H. Liang
Summary: The 18 kDa translocator protein (TSPO) plays a key role in neuroinflammation and several TSPO-targeted PET tracers have been developed, some of which have advanced to clinical research studies.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxiang Tang, Ling Xiao, Chijun Deng, Haoyue Zhu, Xiaomei Gao, Jian Li, Zhiquan Yang, Dingyang Liu, Li Feng, Shuo Hu
Summary: This study investigated the patterns of metabolic abnormalities using [F-18]FDG PET in MTLE patients with different pathologic types. It was found that MTLE patients with isolated gliosis had the worst prognosis and exhibited significant hypometabolism in the insula. Therefore, hypometabolic regions should be prioritized for presurgical evaluation of MTLE patients rather than focusing solely on metabolic uptake values.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Viviane Bouilleret, Stefanie Dedeurwaerdere
Summary: This review discusses the potential of using TSPO PET imaging to provide insights for epilepsy clinic and future treatments targeting neuroinflammatory processes. Despite evidence from preclinical studies showing a correlation between TSPO levels and epilepsy-related factors, TSPO PET imaging has not been widely adopted in clinical settings. Further research is needed to explore the value of TSPO PET in optimizing surgical assessment and supporting the development of anti-inflammatory treatments for epilepsy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Public, Environmental & Occupational Health
April Morrow, Priscilla Chan, Gabriella Tiernan, Julia Steinberg, Deborah Debono, Luke Wolfenden, Katherine M. Tucker, Emily Hogden, Natalie Taylor
Summary: Translating evidence into complex health systems is a challenge, and training healthcare workers in implementation science methods can facilitate evidence-based implementation. The study focused on training hospital-embedded staff in order to improve hereditary cancer referral in Australian hospitals. Participants reported high satisfaction and anticipated the usefulness of the knowledge and skills gained.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2022)
Article
Ethics
Anna M. Scott, E. Ann Bryant, Jennifer A. Byrne, Natalie Taylor, Adrian G. Barnett
Summary: The analysis of the petition comments revealed that signatories were primarily concerned with changes to the research ethics and governance system, the drawbacks of the existing system, suggestions for improvements, anticipated impacts of changes, and miscellaneous issues.
JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS
(2022)
Article
Multidisciplinary Sciences
Michael J. Stacey, Neil E. Hill, Iain T. Parsons, Jenny Wallace, Natalie Taylor, Rachael Grimaldi, Nishma Shah, Anna Marshall, Carol House, John P. O'Hara, Stephen J. Brett, David R. Woods
Summary: This study aimed to investigate whether biomarker surrogates for end-organ damage sampled at point-of-care could discriminate EHI versus successful marathon performance. Results showed that EHI cases had significantly higher levels of NSE, cysC, and copeptin compared to successful finishers, with NSE and copeptin providing excellent discrimination of EHI cases.
Article
Oncology
Gabriella Tiernan, Victoria Freeman, April Morrow, Emily Hogden, Karen Canfell, Yoon-Jung Kang, Natalie Taylor
Summary: The study found that 'knowledge' emerged as a facilitator and 'negative emotional experience' as a barrier in LS diagnosis pathway. Personal supportive views towards genetic testing increased post-interview. Providing guidance/resources to inform decisions around risk-reducing interventions and informing family members is critical when communicating with tumour test-positive CRC patients or their relatives about LS genetic testing.
Editorial Material
Information Science & Library Science
Karen Kettnich, Paul T. Jaeger, Shannon M. Oltmann, Natalie Greene Taylor
Article
Genetics & Heredity
Bettina Meiser, Melissa Monnik, Rachel Austin, Cassandra Nichols, Elisa Cops, Lucinda Salmon, Amanda B. Spurdle, Finlay Macrae, Natalie Taylor, Nicholas Pachter, Paul James, Rajneesh Kaur
Summary: The study aimed to describe the acceptability and perceived barriers and enablers to establish a national registry targeting carriers of pathogenic variants in cancer susceptibility genes. Interviews with stakeholders showed enthusiasm and support for the registry, with carriers and healthcare professionals showing positive attitudes towards its potential research applications. Participants had differing opinions regarding consent approaches and data sharing, highlighting the need for careful consideration in developing and managing such a registry.
JOURNAL OF COMMUNITY GENETICS
(2022)
Article
Psychology, Clinical
David Mizrahi, Christopher T. Swain, Fiona Bruinsma, Allison Hodge, Natalie Taylor, Brigid M. Lynch
Summary: This study aimed to explore the relationship between physical activity, sedentary behavior, and mental health, and identified different associations between different domains of physical activity, television time, and psychological distress. The results suggest that increasing physical activity and reducing television viewing may contribute to decreased psychological distress, especially in women.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Editorial Material
Information Science & Library Science
Paul T. Jaeger, Karen Kettnich, Shannon M. Oltmann, Natalie Greene Taylor, Jane Garner, Jordan S. Sly
Review
Oncology
Elizabeth Todio, Jessica Sharp, April Morrow, Natalie Taylor, Penelope Schofield, Carolyn Mazariego
Summary: This systematic review examines the impact of patient treatment decision-aids (DAs) on decisional outcomes and treatment choice for men diagnosed with localised prostate cancer. The results suggest that DAs have the potential to improve patient knowledge, but do not have significant effects on decisional regret or preparedness.
Article
Endocrinology & Metabolism
Richard J. Auchus, Carine Courtillot, Adrian Dobs, Diala El-Maouche, Henrik Falhammar, Andre Lacroix, Mallory Farrar, Conor O'Donoghue, Milena Anatchkova, Katelyn Cutts, Natalie Taylor, Chuck Yonan, Mark Lamotte, Philippe Touraine
Summary: This study surveyed expert opinions on current treatment practices and unmet needs in adults with classic CAH. The results showed significant variability in treatment practices among clinicians, but all experts agreed on the need for new treatments for classic CAH and the importance of many disease- and GC-related complications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Meeting Abstract
Sport Sciences
David Mizrahi, Christopher T. V. Swain, Fiona Bruinsma, Allison Hodge, Natalie Taylor, Brigid M. Lynch
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Jiat Ling Poon, Shraddha Shinde, Natalie Taylor, Chanadda Chinthammit, Rozanne Wilson, Somali Misra Burgess
Meeting Abstract
Oncology
Joseph Elias, Jordana K. McLoone, Christina Signorelli, Carolyn Mazariego, Skye McKay, Claire E. Wakefield, Richard J. Cohn, Natalie J. Taylor
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Zhicheng Li, Kitty-Jean Laginha, Frances Boyle, Michele Daly, Fiona Dinner, Pia Hirsch, Kim Hobbs, Laura Kirsten, Sophie Lewis, Carolyn Mazariego, Roslyn McAuley, Mary O'Brien, Amanda O'Rielly, Natalie Taylor, Lisa Tobin, Andrea L. Smith
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Carolyn G. Mazariego, Mark Dobson, Skye McKay, Brittany McGill, Rebecca Daly, Claire Wakefield, David Ziegler, Natalie Taylor
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)