Article
Neurosciences
Sebastian Schuster, Leonie Beyer, Carla Palleis, Stefanie Harris, Julia Schmitt, Endy Weidinger, Catharina Prix, Kai Boetzel, Adrian Danek, Boris-Stephan Rauchmann, Sophia Stoecklein, Simon Lindner, Marcus Unterrainer, Nathalie L. Albert, Lena M. Mittlmeier, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Peter Bartenstein, Robert Perneczky, Johannes Levin, Guenter U. Hoeglinger, Matthias Brendel, Franziska J. Dekorsy
Summary: This study aimed to evaluate the use of partial volume effect correction (PVEC) in patients with corticobasal syndrome (CBS) and compare it with a control group. The results showed that after PVEC correction, patients with CBS had smaller regional volumes and increased positivity in TSPO PET.
Article
Biochemistry & Molecular Biology
Luisa Mueller, Nicole Power Guerra, Anna Schildt, Tobias Lindner, Jan Stenzel, Newshan Behrangi, Carina Bergner, Teresa Alberts, Daniel Buehler, Jens Kurth, Bernd Joachim Krause, Deborah Janowitz, Stefan Teipel, Brigitte Vollmar, Angela Kuhla
Summary: Obesity is characterized by excessive fat accumulation, which increases the risk of neurodegenerative disorders and metabolic disturbances. Chronic neuroinflammation plays a crucial role in linking obesity to neurodegenerative disorders. In this study, using PET imaging, we found abnormal brain glucose metabolism and neuroinflammation in female mice with diet-induced obesity. These results suggest that a long-term high-fat diet may induce a metabolically activated state in brain-resident immune cells.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nisha K. Ramakrishnan, Matthew Hird, Stephen Thompson, David J. Williamson, Luxi Qiao, David R. Owen, Allen F. Brooks, Peter J. H. Scott, Sergio Bacallado, John T. O'Brien, Franklin Aigbirhio
Summary: This study evaluated the two enantiomers of [F-18]GE387, showing that (S)-[F-18]GE387 has favorable kinetics in healthy subjects and can distinguish inflamed brain regions in neuroinflammation models, while also demonstrating low sensitivity to TSPO polymorphism in human brain tissue.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, Research & Experimental
Hualong Chen, Zeng Jiang, Xuebo Cheng, Wei Zheng, Yuli Sun, Ziyue Yu, Tingyu Yang, Lu Zhang, Jun Yan, Yajing Liu, Xunming Ji, Zehui Wu
Summary: The short half-life of C-11 limits its clinical application. To overcome this issue, the researchers designed four fluorine-labeled derivatives of ER176 and confirmed their high affinity and suitability in vitro and in vivo. [F-18]BIBD-239 was chosen as a candidate compound for further evaluation due to its simple synthesis conditions and high brain penetration.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Inorganic & Nuclear
Xing-Xing Zhu, Yun-Lin He, Ji-Kui Xie, Kai-Xuan Wang, Shi-Cun Wang, Qiang Xie
Summary: This study aims to streamline the automatic synthesis of [F-18]-GE-180 and improve its accessibility for widespread clinical evaluation. By utilizing an AllinOne synthesis module and SPE purification method, high purity [F-18]-GE-180 was successfully synthesized and showed promising joint imaging performance in an RA animal model.
APPLIED RADIATION AND ISOTOPES
(2022)
Article
Biochemistry & Molecular Biology
Adrien Holzgreve, Dennis Potter, Matthias Brendel, Michael Orth, Lorraine Weidner, Lukas Gold, Maximilian A. Kirchner, Laura M. Bartos, Lena M. Unterrainer, Marcus Unterrainer, Katja Steiger, Louisa von Baumgarten, Maximilian Niyazi, Claus Belka, Peter Bartenstein, Markus J. Riemenschneider, Kirsten Lauber, Nathalie L. Albert
Summary: In this study, TSPO PET imaging and autoradiography were used to investigate the temporal evolution of TSPO radioligand uptake in glioblastoma. The results showed that [F-18]GE-180 PET imaging allows for non-invasive in vivo monitoring of TSPO expression in the GL261 GBM mouse model.
Article
Radiology, Nuclear Medicine & Medical Imaging
M. A. Peyronneau, B. Kuhnast, D-L Nguyen, B. Jego, G. Sayet, F. Caille, S. Lavisse, P. Gervais, B. Stankoff, M. Sarazin, P. Remy, V Bouilleret, C. Leroy, M. Bottlaender
Summary: This study aimed to assess the impact of concomitant medication, age, sex, body mass index, and TSPO binding affinity on the metabolism and plasma pharmacokinetics of [F-18]DPA-714 and their influence on the plasma input function. The results showed significant correlations between concomitant medication, age, sex, body mass index, and [F-18]DPA-714 metabolism and concentration.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Erik Nutma, Kelly Ceyzeriat, Sandra Amor, Stergios Tsartsalis, Philippe Millet, David R. Owen, Vassilios Papadopoulos, Benjamin B. Tournier
Summary: TSPO, located in the outer mitochondrial membrane, is considered an in vivo marker of neuroinflammation as measured with PET. Changes in TSPO expression are observed in neurodegenerative, neuroinflammatory, and neuropsychiatric diseases, but further studies are needed to fully understand its cellular underpinnings and functional significance.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Daehee Kim, Byung Seok Moon, Sun Mi Park, Sang Ju Lee, Seo Young Kang, Sanghui Park, Seung Jun Oh, Bom Sahn Kim, Hai-Jeon Yoon
Summary: This study evaluated the feasibility of a TSPO-specific radiotracer in a rat model of paracetamol-induced liver injury. The results showed that [F-18]GE180 enabled visualization of the liver injury through TSPO overexpression, supporting its potential utility as a non-invasive imaging biomarker for the early phase of PLI.
Article
Chemistry, Medicinal
Chunmei Lu, Xiuting Wang, Qiqi Wang, Lixia Zhang, Jianguo Lin, Ling Qiu
Summary: Legumain is overexpressed in several cancers and serves as an important biomarker for cancer diagnosis. In this study, a novel radioactive tracer [F-18]SF-AAN was designed and synthesized for positron emission tomography (PET) imaging, targeting legumain. The tracer showed specificity in detecting legumain activity in vitro and in vivo, making it a promising tool for the diagnosis of legumain-related diseases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuefeng Yan, Fabrice G. Simeon, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Madeline Jenkins, Lester S. Manly, Maia Van Buskirk, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis, Paolo Zanotti-Fregonara
Summary: This study assessed the ability of [F-18]SF51 to quantify TSPO in rhesus monkey brain. The results demonstrate that [F-18]SF51 is an excellent radioligand that can quantify TSPO with a good ratio of specific to nondisplaceable uptake and has minimal radiometabolite accumulation in brain. These findings suggest that [F-18]SF51 should be further evaluated in humans.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Clinical Neurology
Peng-Fei Zhang, Fan Gao
Summary: Neuroinflammation may play a role in the progression of Parkinson's disease, as evidenced by elevated TSPO levels in various brain regions of PD patients compared to healthy controls. The involvement of neuroinflammation in PD pathogenesis remains ambiguous, with contrasting outcomes depending on the ligand used in the study.
JOURNAL OF NEUROLOGY
(2022)
Review
Pharmacology & Pharmacy
Lingling Zhang, Kuan Hu, Tuo Shao, Lu Hou, Shaojuan Zhang, Weijian Ye, Lee Josephson, Jeffrey H. Meyer, Ming-Rong Zhang, Neil Vasdev, Jinghao Wang, Hao Xu, Lu Wang, Steven H. Liang
Summary: The 18 kDa translocator protein (TSPO) plays a key role in neuroinflammation and several TSPO-targeted PET tracers have been developed, some of which have advanced to clinical research studies.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Medicine, General & Internal
Sally Ji Who Kim, Janine M. Lupo, Yicheng Chen, Miguel H. Pampaloni, Henry F. VanBrocklin, Jared Narvid, Helen Kim, Youngho Seo
Summary: This study shows the potential of using the TSPO PET tracer, flutriciclamide ([F-18]GE-180), as a marker of neuroinflammation in the human brain, specifically in cerebral cavernous malformations (CCM). The study also demonstrates the use of quantitative susceptibility maps (QSM) to analyze the location and amount of iron deposition in CCM lesions. These findings are important for understanding neuroinflammation and disease progression in CCM.
FRONTIERS IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrian Jun Zounek, Nathalie Lisa Albert, Adrien Holzgreve, Marcus Unterrainer, Julia Brosch-Lenz, Simon Lindner, Andreas Bollenbacher, Guido Boening, Rainer Rupprecht, Matthias Brendel, Louisa von Baumgarten, Joerg-Christian Tonn, Peter Bartenstein, Sibylle Ziegler, Lena Kaiser
Summary: This study examined the impact of reconstruction settings and segmentation methods on radiomic features of glioma patients. The results showed that although most features exhibited significant differences, statistical robustness measures improved their stability. ComBat method successfully harmonized feature distributions, but affected features still need to be excluded for clinical utilization.
ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
(2023)
Article
Cardiac & Cardiovascular Systems
Naveed Akbar, Adam T. Braithwaite, Emma M. Corr, Graeme J. Koelwyn, Coen van Solingen, Clement Cochain, Antoine-Emmanuel Saliba, Alastair Corbin, Daniela Pezzolla, Malene Moller Jorgensen, Rikke Baek, Laurienne Edgar, Carla De Villiers, Mala Gunadasa-Rohling, Abhirup Banerjee, Daan Paget, Charlotte Lee, Eleanor Hogg, Adam Costin, Raman Dhaliwal, Errin Johnson, Thomas Krausgruber, Joey Riepsaame, Genevieve E. Melling, Mayooran Shanmuganathan, Christoph Bock, David R. F. Carter, Keith M. Channon, Paul R. Riley, Irina A. Udalova, Kathryn J. Moore, Daniel Anthony, Robin P. Choudhury
Summary: Acute myocardial infarction leads to a rapid increase in blood neutrophils. While chemokine elevation has been considered their source, this study shows that endothelial cell activation can release extracellular vesicles (EVs) that promote mobilization of neutrophils from the spleen to peripheral blood. These EVs carry VCAM-1 and miRNA-126, and their accumulation in the spleen induces inflammatory gene expression and mobilizes splenic neutrophils.
CARDIOVASCULAR RESEARCH
(2023)
Article
Gerontology
Tuulia Koponen, Eliisa Loyttyniemi, Seija Arve, Marja-Liisa Honkasalo, Paivi Rautava
Summary: This study investigated the association between cultural activities and improved quality of life experiences of older people. The results showed that older people who participated in cultural activities had higher quality of life and satisfaction with health compared to those who did not participate. Therefore, care units should emphasize the importance of providing cultural activities for older people.
AGEING INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Ella Koivuniemi, Monique M. Raats, Helena Ollila, Eliisa Loyttyniemi, Kirsi Laitinen
Summary: The study aimed to compare the effects of a standard health app and an enhanced health app on gestational weight gain, diet quality, and physical activity in pregnant women. The results showed that the enhanced app use did not have any benefits on lifestyle habits, but frequent app users had higher physical activity levels in late pregnancy.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Clinical Neurology
Carlo Pozzilli, Maura Pugliatti, Patrick Vermersch, Nikolaos Grigoriadis, Mona Alkhawajah, Laura Airas, Celia Oreja-Guevara
Summary: This article examines the impact of diagnostic definitions of progressive multiple sclerosis (MS) on clinical research, clinical trial design, and treatment decisions. The results show that inconsistent results in clinical studies of treatments for progressive MS may be attributed to differences in patient characteristics and endpoint definitions. Younger patients with more active disease are likely to benefit the most from available treatments. Therefore, treatment decisions should be based on individual patient's disease progression pattern and parameters, rather than their clinical phenotype. Careful selection of eligibility criteria and study endpoints is necessary for future studies in patients with progressive MS.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Imran Waggan, Eero Rissanen, Jouni Tuisku, Juho Joutsa, Semi Helin, Riitta Parkkola, Juha O. Rinne, Laura Airas
Summary: This study investigated A(2A) receptor availability in the striatum and pallidum of early- and moderate-stage PD patients without dyskinesias. The results showed regional and disease stage-dependent changes in A(2A) receptor signaling in PD pathophysiology and in response to dopaminergic medication.
JOURNAL OF NEUROLOGY
(2023)
Article
Infectious Diseases
Sakke Niemela, Laura Lempinen, Eliisa Loyttyniemi, Jarmo Oksi, Jussi Jero
Summary: This study investigated the predisposing factors, clinical characteristics, etiological bacteria spectrum, and clinical outcome of community-acquired and nosocomial bacterial meningitis. The results showed a high rate of unfavorable outcome in both community-acquired and nosocomial bacterial meningitis, indicating the need for further research.
BMC INFECTIOUS DISEASES
(2023)
Article
Environmental Sciences
Marie Tysman, Jorma Toppari, Katharina M. Main, Annika Adamsson, Christine Wohlfahrt-Veje, Jean-Philippe Antignac, Bruno Le Bizec, Eliisa Loyttyniemi, Niels E. Skakkebaek, Helena E. Virtanen
Summary: Hypospadias is a congenital malformation of the penile urethra, and the etiology is mostly unknown. This study investigated the association between hypospadias and exposure to persistent organic pollutants (POPs) through breast milk. The study included Danish and Finnish mother-son pairs, and breast milk samples were analyzed for various classes of POPs. The results did not show any significant associations between POP concentrations and hypospadias in either country. This study provides information on quantitative exposures but does not support a direct link between hypospadias and POP exposure.
Article
Biochemistry & Molecular Biology
Daniel E. Radford-Smith, Abi G. Yates, Laila Rizvi, Daniel C. Anthony, Fay Probert
Summary: This study investigated the impact of lipoprotein subclasses in the blood on lipopolysaccharide-induced neuroinflammation. The results showed that high-density lipoprotein (HDL) exacerbated both peripheral and central inflammation, while low-density lipoprotein (LDL) attenuated this inflammation. The findings suggest that lipoprotein subclasses may be promising therapeutic targets for neuroinflammation and neurodegenerative disorders associated with endotoxemia and sepsis.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Nutrition & Dietetics
Daniel E. Radford-Smith, Daniel C. Anthony
Summary: Emerging evidence suggests that alterations in the gut microbiota can impact mood and contribute to the development of depression through the microbiota-gut-brain axis. Preclinical studies in rodents have demonstrated that prebiotics and probiotics can modulate the gut microbiota and affect neurochemical signaling and inflammatory pathways in the brain. In humans, probiotic supplementation has shown modest antidepressant effects, but further research is needed in clinically relevant populations. This review critically discusses the role of the microbiota-gut-brain axis in depression and emphasizes the importance of rigorous clinical trials and mechanistic understanding for translating preclinical findings into novel therapies.
Article
Neurosciences
Ka Wai Chan, Jennifer Hebert, Daniel Radford-Smith, Daniel C. Anthony, Philip W. J. Burnet
Summary: This study demonstrates that multi-species probiotics can improve emotional behavior in BALB/c mice by regulating the expression of brain cytokines, BDNF, 5HT receptors, and GABA receptors. Interestingly, both live and heat-killed bacteria have similar effects on emotional behaviors and brain gene expression. Therefore, the host response to probiotics is more important than microbial metabolism.
Article
Endocrinology & Metabolism
Nicola Morrice, Susanne Vainio, Kirsi Mikkola, Lidy van Aalten, Jennifer R. Gallagher, Michael L. J. Ashford, Alison D. McNeilly, Rory J. McCrimmon, Alexandra Grosfeld, Patricia Serradas, Jukka Koffert, Ewan R. Pearson, Pirjo Nuutila, Calum Sutherland
Summary: This study aims to investigate the impact of the glucose transporter SLC2A2 on the response to metformin treatment, and reveals the differential response to metformin depending on SLC2A2 expression. It also provides evidence that metformin can modify glucose transport in the gut, contributing to its efficacy. Additionally, this study identifies an important role for this transporter in maintaining efficient glucose homoeostasis during aging.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alex M. Dickens, Tory P. Johnson, Santosh Lamichhane, Anupama Kumar, Carlos A. Pardo, Erie G. Gutierrez, Norman Haughey, Mackenzie C. Cervenka
Summary: This study investigates the clinical outcomes and related factors in patients with super-refractory status epilepticus (SRSE) treated with a ketogenic diet. The results show a significant reduction in pro-inflammatory mediators IL-6 and CXCL13 after 1 and 2 weeks of ketogenic diet treatment, while higher levels of β-hydroxybutyrate in the blood are associated with better clinical outcomes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Nursing
Sanna Koskinen, Anna Brugnolli, Pilar Fuster-Linares, Susan Hourican, Natalja Istomina, Helena Leino-Kilpi, Eliisa Loyttyniemi, Jana Nemcova, Gabriele Meyer, Celia Simao De Oliveira, Alvisa Palese, Marilia Rua, Leena Salminen, Herdis Sveinsdottir, Laura Visiers-Jimenez, Renata Zelenikova, Satu Kajander-Unkuri, ProCompNurse Consortium, COMPEUnurse Consortium
Summary: This study aims to examine the association between nursing education related factors and job satisfaction of newly graduated nurses (NGNs). The findings suggest that nursing education significantly influences the job satisfaction of NGNs, highlighting the importance of career planning during nursing education.
Meeting Abstract
Clinical Neurology
Tianrong Yeo, Halwan Bayuangga, Marcus Augusto-Oliveira, Megan Sealey, Timothy Claridge, Jacqueline Palace, David Leppert, Jens Kuhle, Fay Probert, Daniel Anthony
MULTIPLE SCLEROSIS JOURNAL
(2023)
Letter
Psychiatry
Daniel E. Radford-Smith, Daniel C. Anthony