Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance
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Title
Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance
Authors
Keywords
Platinum, ruthenium, copper, iridium, organoselenium, metal drugs, drug resistance, collateral sensitivity
Journal
DRUG RESISTANCE UPDATES
Volume 58, Issue -, Pages 100778
Publisher
Elsevier BV
Online
2021-08-06
DOI
10.1016/j.drup.2021.100778
References
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Note: Only part of the references are listed.- Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
- (2021) Jing-Quan Wang et al. DRUG RESISTANCE UPDATES
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- (2021) Tuyelee Das et al. DRUG RESISTANCE UPDATES
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- (2021) Jerneja Kladnik et al. Cancers
- Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies
- (2020) Fawzya I. Elshami et al. APPLIED ORGANOMETALLIC CHEMISTRY
- High copper complex stability and slow reduction kinetics as key parameters for improved activity, paraptosis induction and impact on drug-resistant cells of anticancer thiosemicarbazones
- (2020) Sonja Hager et al. ANTIOXIDANTS & REDOX SIGNALING
- The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds
- (2020) Fabrizio Fontana et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Nanomedicine to target multidrug resistant tumors
- (2020) Elise Lepeltier et al. DRUG RESISTANCE UPDATES
- Mitochondria participate in chemoresistance to cisplatin in human ovarian cancer cells
- (2020) Luca X Zampieri et al. MOLECULAR CANCER RESEARCH
- Binding Kinetics of Ruthenium Pyrithione Chemotherapeutic Candidates to Human Serum Proteins Studied by HPLC-ICP-MS
- (2020) Katarina Marković et al. MOLECULES
- Genetic and Physiological Factors Affecting Human Milk Production and Composition
- (2020) Yarden Golan et al. Nutrients
- The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents
- (2020) Jiabei Zhou et al. Frontiers in Pharmacology
- Role of CC Chemokines Subfamily in the Platinum Drugs Resistance Promotion in Cancer
- (2020) Maria E. Reyes et al. Frontiers in Immunology
- Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance
- (2020) Nir Shahar et al. DRUG RESISTANCE UPDATES
- Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells
- (2020) Kateryna Ohui et al. Biomolecules
- Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies
- (2020) Elisabeth Pérez-Ruiz et al. DRUG RESISTANCE UPDATES
- Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux
- (2020) Julia H. Bormio Nunes et al. JOURNAL OF MEDICINAL CHEMISTRY
- Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
- (2019) Reece G. Kenny et al. CHEMICAL REVIEWS
- Potential of natural-based anticancer compounds for P-glycoprotein inhibition
- (2019) Jelena Dinić et al. CURRENT PHARMACEUTICAL DESIGN
- Metal-based antitumor compounds: beyond cisplatin
- (2019) Peter V Simpson et al. Future Medicinal Chemistry
- Platinum Resistance in Ovarian Cancer: Role of DNA Repair
- (2019) Giovanna Damia et al. Cancers
- Mechanisms of Anticancer Drug Resistance in Hepatoblastoma
- (2019) Jose Marin et al. Cancers
- Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent
- (2019) Chilaluck C. Konkankit et al. INORGANIC CHEMISTRY
- Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet
- (2019) Miguel A. Sanz et al. BLOOD
- Biological sulphur-containing compounds – analytical challenges
- (2019) Andrea Raab et al. ANALYTICA CHIMICA ACTA
- YY1 regulates cancer cell immune resistance by modulating PD-L1 expression
- (2019) Emily Hays et al. DRUG RESISTANCE UPDATES
- Polymer “ruthenium-cyclopentadienyl” conjugates - New emerging anti-cancer drugs
- (2019) Tiago Moreira et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression
- (2019) Suxing Jin et al. INORGANIC CHEMISTRY
- NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry
- (2019) Enzo Alessio et al. MOLECULES
- Mechanisms of soft and hard electrophile toxicities
- (2019) Richard M. LoPachin et al. TOXICOLOGY
- The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances
- (2019) Pouya Saraei et al. Cancer Management and Research
- Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC
- (2019) Olivia G. Fast et al. BIOSCIENCE REPORTS
- The thioredoxin system and cancer therapy: a review
- (2019) Fariba Mohammadi et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Immune checkpoint inhibitor combinations: Current efforts and important aspects for success
- (2019) Edo Kon et al. DRUG RESISTANCE UPDATES
- Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding
- (2019) Saif Zaman et al. MOLECULAR CANCER THERAPEUTICS
- Towards Identification of Essential Structural Elements of Organoruthenium(II)‐Pyrithionato Complexes for Anticancer Activity
- (2019) Jerneja Kladnik et al. CHEMISTRY-A EUROPEAN JOURNAL
- The multi-factorial nature of clinical multidrug resistance in cancer
- (2019) Yehuda G. Assaraf et al. DRUG RESISTANCE UPDATES
- Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer
- (2019) Alessandro Leonetti et al. DRUG RESISTANCE UPDATES
- Classification of Metal-Based Drugs according to Their Mechanisms of Action
- (2019) Eszter Boros et al. Chem
- Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing Cells
- (2019) Mihály Cserepes et al. CANCER RESEARCH
- Towards the overcoming of anticancer drug resistance mediated by p53 mutations
- (2019) Xin Cao et al. DRUG RESISTANCE UPDATES
- Advanced technological tools to study multidrug resistance in cancer
- (2019) Luca Andrei et al. DRUG RESISTANCE UPDATES
- A Cisplatin-Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer Therapy
- (2018) Na Wang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development
- (2018) Petra Heffeter et al. ANTIOXIDANTS & REDOX SIGNALING
- Cell-based studies of the first-in-class half-sandwich Ir(III) complex containing histone deacetylase inhibitor 4-phenylbutyrate
- (2018) Pavel Štarha et al. APPLIED ORGANOMETALLIC CHEMISTRY
- Indoleamine 2,3-Dioxygenase (IDO) Inhibition as a Strategy to Augment Cancer Immunotherapy
- (2018) Sarah Yentz et al. BIODRUGS
- T Cell Dysfunction in Cancer
- (2018) Daniela S. Thommen et al. CANCER CELL
- A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells
- (2018) Cheng Ouyang et al. CHEMICAL COMMUNICATIONS
- Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug
- (2018) Keefe Guang Zhi Lee et al. ChemMedChem
- Gold - Old Drug with New Potentials
- (2018) Gavino Faa et al. CURRENT MEDICINAL CHEMISTRY
- Dual Inhibitors as a New Challenge for Cancer Multidrug Resistance Treatment
- (2018) Tijana Stankovica et al. CURRENT MEDICINAL CHEMISTRY
- Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands
- (2018) Salvatore Savino et al. DALTON TRANSACTIONS
- Cyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo
- (2018) Liang He et al. DALTON TRANSACTIONS
- How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
- (2018) Philippe Icard et al. DRUG RESISTANCE UPDATES
- How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance
- (2018) Thorsten Stiewe et al. DRUG RESISTANCE UPDATES
- Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment
- (2018) Valentina Gandin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Methyl-cyclopentadienyl Ruthenium Compounds with 2,2′-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential
- (2018) Leonor Côrte-Real et al. INORGANIC CHEMISTRY
- Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis
- (2018) Yu-Hsuan Lai et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intracellular glutathione-depleting polymeric micelles for cisplatin prodrug delivery to overcome cisplatin resistance of cancers
- (2018) Yu Han et al. JOURNAL OF CONTROLLED RELEASE
- Relevance of copper transporter 1 and organic cation transporters 1–3 for oxaliplatin uptake and drug resistance in colorectal cancer cells
- (2018) I. Buß et al. Metallomics
- Half-Sandwich Ru(II) and Os(II) Bathophenanthroline Complexes Containing a Releasable Dichloroacetato Ligand
- (2018) Pavel Štarha et al. MOLECULES
- Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?
- (2018) Chien Yeo et al. MOLECULES
- Oncosis-inducing cyclometalated iridium(iii) complexes
- (2018) Ruilin Guan et al. Chemical Science
- Resistance-breaking profiling and gene expression analysis on an organometallic ReI–phenanthridine complex reveal parallel activation of two apoptotic pathways
- (2018) Marcel König et al. MedChemComm
- Harnessing albumin as a carrier for cancer therapies
- (2018) Ella N. Hoogenboezem et al. ADVANCED DRUG DELIVERY REVIEWS
- ABC transporters as cancer drivers: Potential functions in cancer development
- (2018) Alice Domenichini et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes
- (2018) Mona M. Saber et al. BMC CANCER
- Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells
- (2018) Jitka Pracharova et al. DALTON TRANSACTIONS
- Correction to A Drug of Such Damned Nature. Challenges and Opportunities in Translational Platinum Drug Research
- (2018) Dorian M. Cheff et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protected and De-protected Platinum(IV) Glycoconjugates With GLUT1 and OCT2-Mediated Selective Cancer Targeting: Demonstrated Enhanced Transporter-Mediated Cytotoxic Properties in vitro and in vivo
- (2018) Jing Ma et al. Frontiers in Chemistry
- Metal Drugs and the Anticancer Immune Response
- (2018) Bernhard Englinger et al. CHEMICAL REVIEWS
- Modulating ROS to overcome multidrug resistance in cancer
- (2018) Qingbin Cui et al. DRUG RESISTANCE UPDATES
- DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death
- (2018) Benoît Thibault et al. Scientific Reports
- Multi-action Pt(IV) anticancer agents; do we understand how they work?
- (2018) Dan Gibson JOURNAL OF INORGANIC BIOCHEMISTRY
- Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand
- (2018) Leonor Côrte-Real et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Cyclometalated iridium(III)-guanidinium complexes as mitochondria-targeted anticancer agents
- (2017) Xing-Dong Song et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of copper and zinc 2-(pyridin-2-yl)imidazo[1,2- a ]pyridine complexes and their potential anticancer activity
- (2017) Jean Dam et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells
- (2017) Xin Chen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Reactive oxygen species and cancer paradox: To promote or to suppress?
- (2017) Sehamuddin Galadari et al. FREE RADICAL BIOLOGY AND MEDICINE
- Genetic variation in the DNA repair pathway as a potential determinant of response to platinum-based chemotherapy in breast cancer
- (2017) Farimah Beheshti et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Rational design of dicarboxylato platinum(II) complexes with purine-mimetic ligands as novel anticancer agents
- (2017) Kamil Hoffmann et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes
- (2017) Kevin M. Knopf et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis
- (2017) Suo-fu Ye et al. Journal of Zhejiang University-SCIENCE B
- Arsenic trioxide decreases the amount and inhibits the function of regulatory T cells, which may contribute to its efficacy in the treatment of acute promyelocytic leukemia
- (2017) Wen Xu et al. LEUKEMIA & LYMPHOMA
- The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency
- (2017) Yarden Golan et al. Metallomics
- Ferrocene–cinchona hybrids with triazolyl-chalcone linkers act as pro-oxidants and sensitize human cancer cell lines to paclitaxel
- (2017) Ana Podolski-Renić et al. Metallomics
- Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53
- (2017) Xin Yu et al. MOLECULAR PHARMACOLOGY
- Nutrient acquisition strategies of mammalian cells
- (2017) Wilhelm Palm et al. NATURE
- Targeting the Thioredoxin System for Cancer Therapy
- (2017) Junmin Zhang et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Cytotoxic (salen)ruthenium(iii) anticancer complexes exhibit different modes of cell death directed by axial ligands
- (2017) Cai Li et al. Chemical Science
- An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo
- (2017) Josef Mayr et al. Chemical Science
- Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry
- (2017) Alice Coletti et al. MedChemComm
- Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression
- (2017) Jianqin Lu et al. Nature Communications
- Metal complexes in cancer therapy – an update from drug design perspective
- (2017) Umar Ndagi et al. Drug Design Development and Therapy
- Metformin partially reverses the carboplatin-resistance in NSCLC by inhibiting glucose metabolism
- (2017) Yong Liu et al. Oncotarget
- Enhanced antitumor efficacy of cisplatin for treating ovarian cancer in vitro and in vivo via transferrin binding
- (2017) Huifang Peng et al. Oncotarget
- New perspectives of cobalt tris(bipyridine) system: anti-cancer effect and its collateral sensitivity towards multidrug-resistant (MDR) cancers
- (2017) Betty Yuen Kwan Law et al. Oncotarget
- GLUT1-mediated selective tumor targeting with fluorine containing platinum(II) glycoconjugates
- (2017) Ran Liu et al. Oncotarget
- Water soluble Ru(ii)–arene complexes of the antidiabetic drug metformin: DNA and protein binding, molecular docking, cytotoxicity and apoptosis-inducing activity
- (2017) Durairaj Gopalakrishnan et al. RSC Advances
- Randomized phase III study (SPEAR) of picoplatin plus best supportive care (BSC) or BSC alone in patients (pts) with SCLC refractory or progressive within 6 months after first-line platinum-based chemotherapy.
- (2017) T. Ciuleanu et al. JOURNAL OF CLINICAL ONCOLOGY
- Metallodrugs in Targeted Cancer Therapeutics: Aiming at Chemoresistance- related Patterns and Immunosuppressive Tumor Networks
- (2017) Savvas Petanidis et al. CURRENT MEDICINAL CHEMISTRY
- A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells
- (2016) Malay Patra et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Resistance to anticancer immunity in cancer patients: potential strategies to reverse resistance
- (2016) B. Bonavida et al. ANNALS OF ONCOLOGY
- Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance
- (2016) Jan Hrabeta et al. Anti-Cancer Agents in Medicinal Chemistry
- Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric Cancer
- (2016) NORIYUKI HAYASHI et al. ANTICANCER RESEARCH
- A copper chelate induces apoptosis and overcomes multidrug resistance in T-cell acute lymphoblastic leukemia through redox imbalance and inhibition of EGFR/PI3K/Akt expression
- (2016) Kaushik Banerjee et al. BIOMEDICINE & PHARMACOTHERAPY
- Identification of selenocompounds with promising properties to reverse cancer multidrug resistance
- (2016) Enrique Domínguez-Álvarez et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The Warburg effect and drug resistance
- (2016) Bhaskar Bhattacharya et al. BRITISH JOURNAL OF PHARMACOLOGY
- The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
- (2016) Timothy C. Johnstone et al. CHEMICAL REVIEWS
- Mono- and Dinuclear Phosphorescent Rhenium(I) Complexes: Impact of Subcellular Localization on Anticancer Mechanisms
- (2016) Rui-Rong Ye et al. CHEMISTRY-A EUROPEAN JOURNAL
- New [(η5-C5H5)Ru(N–N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes
- (2016) Pedro R. Florindo et al. DALTON TRANSACTIONS
- Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation
- (2016) José Alexandre Ferreira et al. DRUG RESISTANCE UPDATES
- ABC transporters as mediators of drug resistance and contributors to cancer cell biology
- (2016) Jamie I. Fletcher et al. DRUG RESISTANCE UPDATES
- Lysosomes as mediators of drug resistance in cancer
- (2016) Benny Zhitomirsky et al. DRUG RESISTANCE UPDATES
- Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
- (2016) Wen Li et al. DRUG RESISTANCE UPDATES
- Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance
- (2016) Veronika F.S. Pape et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Induction of intrinsic and extrinsic apoptosis through oxidative stress in drug-resistant cancer by a newly synthesized Schiff base copper chelate
- (2016) Kaushik Banerjee et al. FREE RADICAL RESEARCH
- Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds
- (2016) Tânia S Morais et al. Future Medicinal Chemistry
- Molecular mode of action of NKP-1339 – a clinically investigated ruthenium-based drug – involves ER- and ROS-related effects in colon carcinoma cell lines
- (2016) Lea S. Flocke et al. INVESTIGATIONAL NEW DRUGS
- Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer
- (2016) Yang Xiong et al. JOURNAL OF CONTROLLED RELEASE
- Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin
- (2016) Juraj Zajac et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Anticancer activity of Ru- and Os(arene) compounds of a maleimide-functionalized bioactive pyridinecarbothioamide ligand
- (2016) Muhammad Hanif et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Structure–Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance
- (2016) Alexandra E. Stacy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics
- (2016) Kyung Chan Park et al. Metallomics
- Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity
- (2016) Gabriele Agonigi et al. ORGANOMETALLICS
- The water soluble ruthenium(II) organometallic compound [Ru( p -cymene)(bis(3,5 dimethylpyrazol-1-yl)methane)Cl]Cl suppresses triple negative breast cancer growth by inhibiting tumor infiltration of regulatory T cells
- (2016) Maura Montani et al. PHARMACOLOGICAL RESEARCH
- Paraptosis in the anti-cancer arsenal of natural products
- (2016) Dongjoo Lee et al. PHARMACOLOGY & THERAPEUTICS
- Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance
- (2016) Mun Juinn Chow et al. Chemical Science
- Mutual regulation and targeting of multidrug resistance and cancer stem phenotype
- (2016) Ana Podolski-Renić et al. MedChemComm
- Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling
- (2016) Walter Miklos et al. Oncotarget
- The association between copper transporters and the prognosis of cancer patients undergoing chemotherapy: a meta-analysis of literatures and datasets
- (2016) Si Sun et al. Oncotarget
- Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells
- (2016) Anna Pastò et al. Oncotarget
- Polymer nanoparticle delivery of dichloroacetate and DACH-Pt to enhance antitumor efficacy and lower systemic toxicity
- (2016) Qiang Yang et al. Biomaterials Science
- Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells
- (2016) Leli Zeng et al. Scientific Reports
- A hybrid platinum drug dichloroacetate-platinum(II) overcomes cisplatin drug resistance through dual organelle targeting
- (2015) Yu Zhang et al. ANTI-CANCER DRUGS
- Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance
- (2015) W. Miklos et al. CANCER LETTERS
- Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors
- (2015) Michael Juchum et al. DRUG RESISTANCE UPDATES
- Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition
- (2015) Ae-Ran Choi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands
- (2015) Gabriele Agonigi et al. INORGANIC CHEMISTRY
- A cyclometalated iridium(III) complex that induces apoptosis in cisplatin-resistant cancer cells
- (2015) Jin-Quan Wang et al. INORGANIC CHEMISTRY COMMUNICATIONS
- Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)
- (2015) Patric J. Jansson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter
- (2015) Nicole A. Seebacher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synthesis and characterization of the anticancer and metal binding properties of novel pyrimidinylhydrazone derivatives
- (2015) Veronika F.S. Pape et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Design, synthesis and anticancer activity of diam(m)ine platinum(II) complexes bearing a small-molecular cell apoptosis inducer dichloroacetate
- (2015) Weiping Liu et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Cyclopentadienyl–Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents
- (2015) Pedro R. Florindo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis
- (2015) Rianne M. Lord et al. JOURNAL OF MEDICINAL CHEMISTRY
- Necroptosis-Inducing Rhenium(V) Oxo Complexes
- (2015) Kogularamanan Suntharalingam et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy
- (2015) Samuel G. Awuah et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance
- (2015) E. Martinez-Balibrea et al. MOLECULAR CANCER THERAPEUTICS
- Diaminohexopyranosides as Ligands in Half-Sandwich Ruthenium(II), Rhodium(III), and Iridium(III) Complexes
- (2015) Matthias Böge et al. ORGANOMETALLICS
- Auranofin: Repurposing an Old Drug for a Golden New Age
- (2015) Christine Roder et al. Drugs in research & development
- Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
- (2015) Daniela Catanzaro et al. Oncotarget
- Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells
- (2015) Hongyu Li et al. Oncotarget
- Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update
- (2014) Qingcheng Mao et al. AAPS Journal
- Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents
- (2014) Anna Leonidova et al. ACS Chemical Biology
- The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells
- (2014) Qinqin Cheng et al. CHEMICAL COMMUNICATIONS
- Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance
- (2014) Gergely Szakács et al. CHEMICAL REVIEWS
- On the Stability of PtIVPro-Drugs with Haloacetato Ligands in the Axial Positions
- (2014) Ezequiel Wexselblatt et al. CHEMISTRY-A EUROPEAN JOURNAL
- The folate receptor as a rational therapeutic target for personalized cancer treatment
- (2014) Yehuda G. Assaraf et al. DRUG RESISTANCE UPDATES
- A copper chelate selectively triggers apoptosis in myeloid-derived suppressor cells in a drug-resistant tumor model and enhances antitumor immune response
- (2014) Paramita Chakraborty et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes
- (2014) Leonor Côrte-Real et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery
- (2014) Yao-Rong Zheng et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Mechanism of cellular accumulation of an iridium(iii) pentamethylcyclopentadienyl anticancer complex containing a C,N-chelating ligand
- (2014) Vojtech Novohradsky et al. Metallomics
- A dual-targeting, p53-independent, apoptosis-inducing platinum(ii) anticancer complex, [Pt(BDIQQ)]Cl
- (2014) Kogularamanan Suntharalingam et al. Metallomics
- Employing Pancreatic Tumor γ-Glutamyltransferase for Therapeutic Delivery
- (2014) Emma E. Ramsay et al. MOLECULAR PHARMACEUTICS
- Cellular Transport Mechanisms of Cytotoxic Metallodrugs: An Overview beyond Cisplatin
- (2014) Sarah Spreckelmeyer et al. MOLECULES
- NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
- (2014) Robert Trondl et al. Chemical Science
- Glutathione S-conjugates as prodrugs to target drug-resistant tumors
- (2014) Emma E. Ramsay et al. Frontiers in Pharmacology
- Nanoparticle Encapsulation of Mitaplatin and the Effect Thereof on In Vivo Properties
- (2013) Timothy C. Johnstone et al. ACS Nano
- Rationally designed nanovehicles to overcome cancer chemoresistance
- (2013) Yoav D. Livney et al. ADVANCED DRUG DELIVERY REVIEWS
- Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells
- (2013) Mamoru Tanaka et al. BMC CANCER
- Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing
- (2013) Ana Podolski-Renić et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment
- (2013) E. M. Dijkgraaf et al. CANCER RESEARCH
- Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery
- (2013) Verena Pichler et al. CHEMICAL COMMUNICATIONS
- Synthesis, molecular structure, computational study and in vitro anticancer activity of dinuclear thiolato-bridged pentamethylcyclopentadienyl Rh(iii) and Ir(iii) complexes
- (2013) Gajendra Gupta et al. DALTON TRANSACTIONS
- A novel manganese complex, Mn-(II) N-(2-hydroxy acetophenone) glycinate overcomes multidrug-resistance in cancer
- (2013) Ruma Dey Ghosh et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Picoplatin pharmacokinetics and chemotherapy of non-small cell lung cancer
- (2013) Gerhard Hamilton et al. Expert Opinion on Drug Metabolism & Toxicology
- Biological activity and cellular uptake of [Ru(η5-C5H5)(PPh3)(Me2bpy)][CF3SO3] complex
- (2013) Tânia S. Morais et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- First polymer “ruthenium-cyclopentadienyl” complex as potential anticancer agent
- (2013) Andreia Valente et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- The Contrasting Activity of Iodido versus Chlorido Ruthenium and Osmium Arene Azo- and Imino-pyridine Anticancer Complexes: Control of Cell Selectivity, Cross-Resistance, p53 Dependence, and Apoptosis Pathway
- (2013) Isolda Romero-Canelón et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, characterization and cytotoxicity of cyclopentadienyl ruthenium(II) complexes containing carbohydrate-derived ligands
- (2013) Pedro Florindo et al. JOURNAL OF ORGANOMETALLIC CHEMISTRY
- Fluorescent silver(i) and gold(i)–N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights
- (2013) Anna Citta et al. Metallomics
- Gallium phosphinoarylbisthiolato complexes counteract drug resistance of cancer cells
- (2013) Eva Fischer-Fodor et al. Metallomics
- Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
- (2013) K. Kryeziu et al. MOLECULAR CANCER THERAPEUTICS
- Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group
- (2013) Weiping Liu et al. Scientific Reports
- Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: Implications for the emergence and reversal of cancer drug resistance
- (2012) Csilla Hegedüs et al. BIOCHEMICAL PHARMACOLOGY
- Acquisition of an enhanced aggressive phenotype in human lung cancer cells selected by suboptimal doses of cisplatin following cell deattachment and reattachment
- (2012) Jeng-Long Hsieh et al. CANCER LETTERS
- Dose-Dense Chemotherapy Improves Mechanisms of Antitumor Immune Response
- (2012) C.-L. Chang et al. CANCER RESEARCH
- Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity
- (2012) Sarah D. Brown et al. DALTON TRANSACTIONS
- Synthesis and characterization of azolate gold(i) phosphane complexes as thioredoxin reductase inhibiting antitumor agents
- (2012) Rossana Galassi et al. DALTON TRANSACTIONS
- Collateral sensitivity as a strategy against cancer multidrug resistance
- (2012) Kristen M. Pluchino et al. DRUG RESISTANCE UPDATES
- Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance
- (2012) Nitzan Gonen et al. DRUG RESISTANCE UPDATES
- [RuII(η5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin
- (2012) Ana Isabel Tomaz et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Reprogramming of TAM toward proimmunogenic type through regulation of MAP kinases using a redox-active copper chelate
- (2012) P. Chakraborty et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Gold(I) Carbene Complexes Causing Thioredoxin 1 and Thioredoxin 2 Oxidation as Potential Anticancer Agents
- (2012) Esther Schuh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Quantitative immunoproteomics analysis reveals novel MHC class I presented peptides in cisplatin-resistant ovarian cancer cells
- (2012) Vivekananda Shetty et al. Journal of Proteomics
- The molecular interaction of a copper chelate with human P-glycoprotein
- (2012) Ruma Dey Ghosh et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Mitaplatin Increases Sensitivity of Tumor Cells to Cisplatin by Inducing Mitochondrial Dysfunction
- (2012) Xue Xue et al. MOLECULAR PHARMACEUTICS
- Drug Transporters in Drug Efficacy and Toxicity
- (2011) M.K. DeGorter et al. Annual Review of Pharmacology and Toxicology
- Anticancer Activity of Metal Complexes: Involvement of Redox Processes
- (2011) Ute Jungwirth et al. ANTIOXIDANTS & REDOX SIGNALING
- The transferrin receptor and the targeted delivery of therapeutic agents against cancer
- (2011) Tracy R. Daniels et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Iron N-(2-hydroxy acetophenone) glycinate (FeNG), a non-toxic glutathione depletor circumvents doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo
- (2011) Avishek Ganguly et al. BIOMETALS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules
- (2011) Muhammad Hanif et al. CHEMICAL COMMUNICATIONS
- Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation
- (2011) Lorien J. Parker et al. CHEMISTRY-A EUROPEAN JOURNAL
- Evaluation of Platinum-Ethacrynic Acid Conjugates in the Treatment of Mesothelioma
- (2011) Ilaria Zanellato et al. ChemMedChem
- An in vitro and in vivo study of a novel zinc complex, zinc N-(2-hydroxyacetophenone)glycinate to overcome multidrug resistance in cancer
- (2011) Ruma Dey Ghosh et al. DALTON TRANSACTIONS
- Nitroimidazole and glucosamine conjugated heteroscorpionate ligands and related copper(ii) complexes. Syntheses, biological activity and XAS studies
- (2011) Maura Pellei et al. DALTON TRANSACTIONS
- Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells
- (2011) Iryna N. Stepanenko et al. INORGANIC CHEMISTRY
- Overcoming cisplatin resistance using gold(III) mimics: Anticancer activity of novel gold(III) polypyridyl complexes
- (2011) Kamalakannan Palanichamy et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity
- (2011) Patrycja Nowak-Sliwinska et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Structure–Activity Evaluation of Isatin-β-thiosemicarbazones with Improved Selective Activity toward Multidrug-Resistant Cells Expressing P-Glycoprotein
- (2011) Matthew D. Hall et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selection of radioresistant tumor cells and presence of ALDH1 activity in vitro
- (2011) Julia Mihatsch et al. RADIOTHERAPY AND ONCOLOGY
- Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm
- (2010) Leticia Cubo et al. ChemMedChem
- Synthesis of hybrid transition-metalloproteins via thiol-selective covalent anchoring of Rh-phosphine and Ru-phenanthroline complexes
- (2010) René den Heeten et al. DALTON TRANSACTIONS
- In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands
- (2010) Carlo Santini et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Copper Transporters and the Cellular Pharmacology of the Platinum-Containing Cancer Drugs
- (2010) S. B. Howell et al. MOLECULAR PHARMACOLOGY
- Targeting Mitochondrial Cell Death Pathway to Overcome Drug Resistance with a Newly Developed Iron Chelate
- (2010) Avishek Ganguly et al. PLoS One
- Rational Design of an Organometallic Glutathione Transferase Inhibitor
- (2009) Wee Han Ang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase
- (2009) Valentina Gandin et al. BIOCHEMICAL PHARMACOLOGY
- Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells
- (2009) D. Turk et al. CANCER RESEARCH
- Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, inâ vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands
- (2009) Elena Vergara et al. ChemMedChem
- Ribonucleotide Reductase as One Important Target of [Tris(1,10- phenanthroline)lanthanum(III)] Trithiocyanate (KP772)
- (2009) P. Heffeter et al. CURRENT CANCER DRUG TARGETS
- Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo
- (2009) Qiang Tan et al. INVESTIGATIONAL NEW DRUGS
- The Thioxotriazole Copper(II) Complex A0 Induces Endoplasmic Reticulum Stress and Paraptotic Death in Human Cancer Cells
- (2009) Saverio Tardito et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase II Study of Picoplatin As Second-Line Therapy for Patients With Small-Cell Lung Cancer
- (2009) John R. Eckardt et al. JOURNAL OF CLINICAL ONCOLOGY
- Optimization of the Antitumor Efficacy of a Synthetic Mitochondrial Toxin by Increasing the Residence Time in the Cytosol
- (2009) Pierre J. Dilda et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, Activity, and Pharmacophore Development for Isatin-β-thiosemicarbazones with Selective Activity toward Multidrug-Resistant Cells
- (2009) Matthew D. Hall et al. JOURNAL OF MEDICINAL CHEMISTRY
- Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line
- (2009) S. M. Matulis et al. MOLECULAR CANCER THERAPEUTICS
- Structural Determinants of Imidazoacridinones Facilitating Antitumor Activity Are Crucial for Substrate Recognition by ABCG2
- (2009) E. E. Bram et al. MOLECULAR PHARMACOLOGY
- Immunogenic death of colon cancer cells treated with oxaliplatin
- (2009) A Tesniere et al. ONCOGENE
- A Novel Copper Chelate Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells
- (2009) Shilpak Chatterjee et al. PLoS One
- Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate
- (2009) Shanta Dhar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In Vitro Anticancer Activity and Biologically Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate-Based Ligands
- (2008) Isabella Berger et al. CHEMISTRY-A EUROPEAN JOURNAL
- Prediction of Broad Spectrum Resistance of Tumors towards Anticancer Drugs
- (2008) T. Efferth et al. CLINICAL CANCER RESEARCH
- Current Status and Future Prospects for Satraplatin, an Oral Platinum Analogue
- (2008) H. Choy et al. CLINICAL CANCER RESEARCH
- Resistance against novel anticancer metal compounds: Differences and similarities
- (2008) P HEFFETER et al. DRUG RESISTANCE UPDATES
- Selenoproteins
- (2008) Jun Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cellular accumulation and cytotoxicity of macromolecular platinum complexes in cisplatin-resistant tumor cells
- (2008) Dirk Garmann et al. JOURNAL OF CONTROLLED RELEASE
- Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
- (2008) Felix Kratz JOURNAL OF CONTROLLED RELEASE
- The Role of the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-Based Drugs
- (2008) C. A. Larson et al. MOLECULAR PHARMACOLOGY
- The BCL-2 protein family: opposing activities that mediate cell death
- (2007) Richard J. Youle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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