The Warburg effect and drug resistance

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Overview

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing

(2015) Valentina Tesori et al.   Scientific Reports

Inhibiting the molecular evolution of cancer through HSP90

(2015) Ana Sofia Martins et al.   Oncotarget

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming

(2015) Veronica Martinez-Marignac et al.   Oncotarget

Hypoxia-Induced Energy Stress Inhibits the mTOR Pathway by Activating an AMPK/REDD1 Signaling Axis in Head and Neck Squamous Cell Carcinoma

(2015) Abraham Schneider et al.   NEOPLASIA

Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression

(2015) Benjamin Le Calvé et al.   NEOPLASIA

Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype

(2014) B Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy modulation: a target for cancer treatment development

(2014) Alison Duffy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy

(2014) J.-M. Xie et al.   CANCER RESEARCH

INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells

(2013) Joong Won Min et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

(2013) Karl J Morten et al.   JOURNAL OF PATHOLOGY

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Tumor Metabolism of Malignant Gliomas

(2013) Peng Ru et al.   Cancers

Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level

(2012) Oh-Hyung Kwon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy

(2012) S. K. McBrayer et al.   BLOOD

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

(2012) Y-C Shen et al.   BRITISH JOURNAL OF CANCER

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

From tumor cell metabolism to tumor immune escape

(2012) Martin Villalba et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

(2012) Swen Hoelder et al.   Molecular Oncology

Cancer stem cells and drug resistance: the potential of nanomedicine

(2012) Serguei Vinogradov et al.   Nanomedicine

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Multiple Metabolic Alterations Exist in Mutant PI3K Cancers, but Only Glucose Is Essential as a Nutrient Source

(2012) Rebecca Foster et al.   PLoS One

Metabolic Stress in Autophagy and Cell Death Pathways

(2012) B. J. Altman et al.   Cold Spring Harbor Perspectives in Biology

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs

(2011) Hiroko Onozuka et al.   CANCER SCIENCE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

A Warburg shakeup

(2011) Catherine Goodman   Nature Chemical Biology

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

(2010) Saroj P. Mathupala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxidative phosphorylation in cancer cells

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression

(2010) Rodrigo Diaz-Ruiz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

(2010) Hua-shan Shi et al.   CANCER SCIENCE

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Effects of the HIV Protease Inhibitor Ritonavir on GLUT4 Knock-out Mice

(2010) Arpita Kalla Vyas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model

(2010) Wenhao Guo et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

(2009) Marie-José Blouin et al.   CANCER LETTERS

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

(2009) S. Saito et al.   CANCER RESEARCH

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

(2009) Yuri Kim et al.   CURRENT MOLECULAR MEDICINE

Upregulation of glycolytic enzymes in proteins secreted from human colon cancer cells with 5-fluorouracil resistance

(2009) Young-Kyoung Shin et al.   ELECTROPHORESIS

A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines

(2009) E. Martinez-Balibrea et al.   MOLECULAR CANCER THERAPEUTICS

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

(2008) Carolyn L. Buller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator

(2007) Ji-Hwan Hwang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro

(2007) Amy M. Kleman et al.   JOURNAL OF NEUROSCIENCE METHODS