Auranofin: Repurposing an Old Drug for a Golden New Age

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

(2015) Xin Chen et al.   Oncotarget

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

(2015) Ningning Liu et al.   Oncotarget

Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia

(2014) W. Fiskus et al.   CANCER RESEARCH

Auranofin and related heterometallic gold(I)–thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains

(2014) Yozane Hokai et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst

(2014) Jocelyn M. Madeira et al.   JOURNAL OF NEUROIMMUNOLOGY

Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo

(2014) C Fan et al.   Cell Death & Disease

Auranofin Is Highly Efficacious against Toxoplasma gondii In Vitro and in an In Vivo Experimental Model of Acute Toxoplasmosis

(2014) Rosa M. Andrade et al.   PLoS Neglected Tropical Diseases

Treatment of Giardiasis: Current Status and Future Directions

(2014) Richard R. Watkins et al.   Current Infectious Disease Reports

Auranofin Is an Apoptosis-Simulating Agent with in Vitro and in Vivo Anti-leishmanial Activity

(2013) Elizabeth R. Sharlow et al.   ACS Chemical Biology

A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia

(2013) Noa Tejman-Yarden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel protective properties of auranofin: Inhibition of human astrocyte cytotoxic secretions and direct neuroprotection

(2013) J.M. Madeira et al.   LIFE SCIENCES

Drug Repurposing for Gastrointestinal Stromal Tumor

(2013) Z. Y. Pessetto et al.   MOLECULAR CANCER THERAPEUTICS

Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS

(2013) Iart Shytaj et al.   Retrovirology

A candidate anti-HIV reservoir compound, auranofin, exerts a selective ‘anti-memory’ effect by exploiting the baseline oxidative status of lymphocytes

(2013) B Chirullo et al.   Cell Death & Disease

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

(2011) Andrea Ilari et al.   AMINO ACIDS

Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition

(2011) Antonia Caroli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Selenium-Dependent Xanthine Dehydrogenase Triggers Biofilm Proliferation in Enterococcus faecalis through Oxidant Production

(2011) M. Srivastava et al.   JOURNAL OF BACTERIOLOGY

Inhibition of Selenium Metabolism in the Oral Pathogen Treponema denticola

(2009) S. Jackson-Rosario et al.   JOURNAL OF BACTERIOLOGY

Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au–Se adduct

(2009) Sarah Jackson-Rosario et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The FDA Critical Path Initiative and Its Influence on New Drug Development

(2008) Janet Woodcock et al.   Annual Review of Medicine

New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro : Mechanistic and pharmacological implications

(2008) Anna Rosa Sannella et al.   FEBS LETTERS

Platyhelminth Mitochondrial and Cytosolic Redox Homeostasis Is Controlled by a Single Thioredoxin Glutathione Reductase and Dependent on Selenium and Glutathione

(2008) Mariana Bonilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical pharmacology of gold

(2008) W. F. Kean et al.   INFLAMMOPHARMACOLOGY