Anticancer Activity of Metal Complexes: Involvement of Redox Processes

Titanium and Vanadium Complexes as Anticancer Agents

(2012) Irena Kostova   Anti-Cancer Agents in Medicinal Chemistry

Vitamin B12-Mediated Transport: A Potential Tool for Tumor Targeting of Antineoplastic Drugs and Imaging Agents

(2012) Yashwant Gupta et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA

(2011) Elisabeth Hedström et al.   CELL CYCLE

Peroxiredoxin 1 and its role in cell signaling

(2011) Carola A. Neumann et al.   CELL CYCLE

Intermolecular disulfide bond to modulate protein function as a redox-sensing switch

(2010) N. Nagahara   AMINO ACIDS

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

(2010) Ines Batinić-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular pathways for transport and efflux of ascorbate and dehydroascorbate

(2010) Alessandro Corti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

New dirhodium complex with activity towards colorectal cancer

(2010) Raquel F.M. Frade et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The metal-responsive transcription factor-1 protein is elevated in human tumors

(2010) Yihui Shi et al.   CANCER BIOLOGY & THERAPY

Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator

(2010) Seiko Ishida et al.   CANCER CELL

Vanadium in the detection, prevention and treatment of cancer: The in vivo evidence

(2010) Anupam Bishayee et al.   CANCER LETTERS

New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs

(2010) Alina Nemirovski et al.   CHEMICAL COMMUNICATIONS

Chemical Methods To Evaluate Antioxidant Ability

(2010) Zai-Qun Liu   CHEMICAL REVIEWS

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

(2010) L. Zitvogel et al.   CLINICAL CANCER RESEARCH

Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells

(2010) Amélie Rebillard et al.   EUROPEAN JOURNAL OF CANCER

A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo

(2010) Chad N. Hancock et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effect of metallothionein on oxidative stress-induced DNA damage

(2010) Natalie Chiaverini et al.   FREE RADICAL RESEARCH

Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

(2010) Shruti Singh et al.   FREE RADICAL RESEARCH

Hypoxia-activated prodrugs in cancer therapy: progress to the clinic

(2010) William A Denny   Future Oncology

Is Vanadate Reduced by Thiols under Biological Conditions? Changing the Redox Potential of V(V)/V(IV) by Complexation in Aqueous Solution

(2010) Debbie C. Crans et al.   INORGANIC CHEMISTRY

Arsenic trioxide induces endoplasmic reticulum stress-related events in neutrophils

(2010) François Binet et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

(2010) Petra Heffeter et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic study

(2010) Francesca Magherini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Vitamin B12 as a carrier for targeted platinum delivery: in vitro cytotoxicity and mechanistic studies

(2010) Pilar Ruiz-Sánchez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Metabolism and the leukemic stem cell: Figure 1.

(2010) Omar Abdel-Wahab et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Auranofin, a Gold(I)-Containing Antirheumatic Compound, Activates Keap1/Nrf2 Signaling via Rac1/iNOS Signal and Mitogen-Activated Protein Kinase Activation

(2010) Nam-Hoon Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Copper Transporters and the Cellular Pharmacology of the Platinum-Containing Cancer Drugs

(2010) S. B. Howell et al.   MOLECULAR PHARMACOLOGY

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Manganese Corroles Prevent Intracellular Nitration and Subsequent Death of Insulin-Producing Cells

(2009) Zoya Okun et al.   ACS Chemical Biology

Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen Species

(2009) Yuichiro Shimizu et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

(2009) Georg T. Wondrak   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

(2009) Andrew G. Cox et al.   BIOCHEMICAL JOURNAL

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase

(2009) Valentina Gandin et al.   BIOCHEMICAL PHARMACOLOGY

Effects of Polyamines on the DNA-Reactive Properties of Dimeric Mithramycin Complexed with Cobalt(II): Implications for Anticancer Therapy

(2009) Ming-Hon Hou et al.   BIOCHEMISTRY

Glutathione peroxidases in different stages of carcinogenesis

(2009) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Arsenite medicinal use, metabolism, pharmacokinetics and monitoring in human hair

(2009) I. Nicolis et al.   BIOCHIMIE

Unusual DNA binding modes for metal anticancer complexes

(2009) Ana M. Pizarro et al.   BIOCHIMIE

Vitamin C: update on physiology and pharmacology

(2009) J Mandl et al.   BRITISH JOURNAL OF PHARMACOLOGY

A pharmacokinetic and safety study of intravenous arsenic trioxide in adult cancer patients with renal impairment

(2009) Christopher J. Sweeney et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Genistein synergizes with arsenic trioxide to suppress human hepatocellular carcinoma

(2009) Hongchi Jiang et al.   CANCER SCIENCE

Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: Therapeutic potential for ovarian cancer

(2009) Ning Zhang et al.   CANCER SCIENCE

Apoptosis and glutathione: beyond an antioxidant

(2009) R Franco et al.   CELL DEATH AND DIFFERENTIATION

Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands

(2009) Elena Vergara et al.   ChemMedChem

A Phase I Clinical Trial of Darinaparsin in Patients with Refractory Solid Tumors

(2009) A. M. Tsimberidou et al.   CLINICAL CANCER RESEARCH

The tumor proteasome as a novel target for gold(III) complexes: Implications for breast cancer therapy

(2009) Vesna Milacic et al.   COORDINATION CHEMISTRY REVIEWS

Oral exposure to inorganic arsenic: evaluation of its carcinogenic and non-carcinogenic effects

(2009) Ulrike Schuhmacher–Wolz et al.   CRITICAL REVIEWS IN TOXICOLOGY

Ribonucleotide Reductase as One Important Target of [Tris(1,10- phenanthroline)lanthanum(III)] Trithiocyanate (KP772)

(2009) P. Heffeter et al.   CURRENT CANCER DRUG TARGETS

Metal Complexes, their Cellular Targets and Potential for Cancer Therapy

(2009) Di Chen et al.   CURRENT PHARMACEUTICAL DESIGN

The mechanism of action of platinum anticancer agents—what do we really know about it?

(2009) Dan Gibson   DALTON TRANSACTIONS

Toxic effects of hexaammine cobalt(III) chloride on liver and kidney in mice: Implication of oxidative stress

(2009) Amarjit S. Naura et al.   DRUG AND CHEMICAL TOXICOLOGY

Darinaparsin: a novel organic arsenical with promising anticancer activity

(2009) Koren K Mann et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

γ-Glutamyltransferase-dependent resistance to arsenic trioxide in melanoma cells and cellular sensitization by ascorbic acid

(2009) Chiara Giommarelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

(2009) Zahid N. Rabbani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of superoxide dismutase genes: Implications in disease

(2009) Lu Miao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma

(2009) Jennifer Wu et al.   INVESTIGATIONAL NEW DRUGS

MER1, a novel organic arsenic derivative, has potent PML-RARα- independent cytotoxic activity against leukemia cells

(2009) Mirna Golemovic et al.   INVESTIGATIONAL NEW DRUGS

Reactive Oxygen Species Are Not Required for an Arsenic Trioxide-induced Antioxidant Response or Apoptosis

(2009) Alejo A. Morales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes

(2009) Xia Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Terpyridine–platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1

(2009) Yan-Chung Lo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and Evaluation of Stable Bidentate Transition Metal Complexes of 1-(Chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as Hypoxia Selective Cytotoxins

(2009) Jared B. J. Milbank et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impact of Metal Coordination on Cytotoxicity of 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (Triapine) and Novel Insights into Terminal Dimethylation

(2009) Christian R. Kowol et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors

(2009) Yu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cardioprotection by Vanadium Compounds Targeting Akt-Mediated Signaling

(2009) Md. Shenuarin Bhuiyan et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Live Cell Cytotoxicity Studies: Documentation of the Interactions of Antitumor Active Dirhodium Compounds with Nuclear DNA

(2009) J. Dafhne Aguirre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line

(2009) S. M. Matulis et al.   MOLECULAR CANCER THERAPEUTICS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

A Novel Copper Chelate Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells

(2009) Shilpak Chatterjee et al.   PLoS One

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

(2009) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation

(2009) H. M. Alvarez et al.   SCIENCE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Ceruloplasmin/Transferrin System Is Related to Clinical Status in Acute Stroke

(2009) Claudia Altamura et al.   STROKE

Cisplatin impairs rat liver mitochondrial functions by inducing changes on membrane ion permeability: Prevention by thiol group protecting agents

(2009) José B.A. Custódio et al.   TOXICOLOGY

Protein S-glutathionylation: a regulatory device from bacteria to humans

(2009) Isabella Dalle-Donne et al.   TRENDS IN BIOCHEMICAL SCIENCES

Copper is taken up efficiently from albumin and α2-macroglobulin by cultured human cells by more than one mechanism

(2008) Mizue Moriya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis

(2008) Heejeong Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metal and Ligand Control of Sulfenate Reactivity: Arene Ruthenium Thiolato-Mono-S-Oxides

(2008) Holm Petzold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Phase II Trial of Tetrathiomolybdate After Surgery for Malignant Mesothelioma: Final Results

(2008) Harvey I. Pass et al.   ANNALS OF THORACIC SURGERY

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

(2008) Elizabeth L. Mackenzie et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

(2008) Detmar Beyersmann et al.   ARCHIVES OF TOXICOLOGY

Redox compartmentalization in eukaryotic cells

(2008) Young-Mi Go et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia

(2008) S Talbot et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism

(2008) Benjamin D. Bowling et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH

(2008) Yong Hwan Han et al.   CANCER LETTERS

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

Cisplatin Cytotoxicity: DNA and Plasma Membrane Targets

(2008) Amelie Rebillard et al.   CURRENT MEDICINAL CHEMISTRY

Resistance against novel anticancer metal compounds: Differences and similarities

(2008) P HEFFETER et al.   DRUG RESISTANCE UPDATES

Gold(I) complexes determine apoptosis with limited oxidative stress in Jurkat T cells

(2008) Maria Pia Rigobello et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity

(2008) Yolanda I. Chirino et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Methionine in proteins defends against oxidative stress

(2008) Shen Luo et al.   FASEB JOURNAL

Genistein selectively potentiates arsenic trioxide‐induced apoptosis in human leukemia cellsviareactive oxygen species generation and activation of reactive oxygen species‐inducible protein kinases (p38‐MAPK, AMPK)

(2008) Yolanda Sánchez et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolism of the Tumor Angiogenesis Inhibitor 4-(N-(S-Glutathionylacetyl)amino)phenylarsonous Acid

(2008) Pierre J. Dilda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role for GlutathioneS-Transferase π

(2008) Danyelle M. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular uptake and distribution of cobalt complexes of fluorescent ligands

(2008) Natsuho Yamamoto et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

(2008) Angela Casini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer Activity

(2008) Paul V. Bernhardt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity

(2008) M. Jiang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

(2008) V. Hellberg et al.   JNCI-Journal of the National Cancer Institute

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology

(2008) Nazzareno Ballatori et al.   MOLECULAR ASPECTS OF MEDICINE

Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy

(2008) Kathryn F. Tonissen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Catalytic organometallic anticancer complexes

(2008) S. J. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of metallothionein in oncogenesis and cancer prognosis

(2008) Mie Ø. Pedersen et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Insight into the reactive form of the anticancer agent iproplatin

(2007) Erika Volckova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intracellular labile iron

(2007) William Breuer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver

(2007) N. M. Martins et al.   JOURNAL OF APPLIED TOXICOLOGY

Glutathionato-S-Gold(III) complexes formed as intermediates in the reduction of auricyanide by glutathione

(2007) Philip M. Yangyuoru et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Dithiothreitol abrogates the effect of arsenic trioxide on normal rat liver mitochondria and human hepatocellular carcinoma cells

(2007) Manash K. Paul et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Electron-transfer activated metal-based anticancer drugs

(2006) Erwin Reisner et al.   INORGANICA CHIMICA ACTA