Cancer cells dysregulate PI3K/AKT/mTOR pathway activation to ensure their survival and proliferation: mimicking them is a smart strategy of gammaherpesviruses

IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by Promoting Cytokine Release and STAT3 Activation

(2021) Roberta Gonnella et al.   Biomedicines

NRF2 as a regulator of cell metabolism and inflammation in cancer

(2020) Feng He et al.   CARCINOGENESIS

KSHV dysregulates bulk macroautophagy, mitophagy and UPR to promote endothelial to mesenchymal transition and CCL2 release, key events in viral‐driven sarcomagenesis

(2020) Roberta Santarelli et al.   INTERNATIONAL JOURNAL OF CANCER

The Innovative Potential of Statins in Cancer: New Targets for New Therapies

(2020) Elisabetta Di Bello et al.   Frontiers in Chemistry

STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

(2020) Maria Anele Romeo et al.   Frontiers in Oncology

STAT3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation

(2019) Roberta Santarelli et al.   VIROLOGY

mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars

(2019) Gemma Sangüesa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR and Aging: An Old Fashioned Dress

(2019) Giovanni Stallone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

(2019) Mara Cirone et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization

(2019) Granato et al.   Biomolecules

Role of AKT and mTOR signaling pathways in the induction of epithelial-mesenchymal transition (EMT) process

(2019) Mostafa Karimi Roshan et al.   BIOCHIMIE

HSF1-Mediated Control of Cellular Energy Metabolism and mTORC1 Activation Drive Acute T-Cell Lymphoblastic Leukemia Progression

(2019) Binnur Eroglu et al.   MOLECULAR CANCER RESEARCH

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

(2019) Cedric Magaway et al.   Cells

mTORC1 pathway in DNA damage response

(2018) Yinxing Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease

(2018) Angela Jeong et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Role of mTOR in Glucose and Lipid Metabolism

(2018) Zhuo Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target

(2018) Ramona Schulz-Heddergott et al.   Cancers

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia

(2018) Oro Uchenunu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

p62/ SQSTM 1: ‘Jack of all trades’ in health and cancer

(2018) Pablo Sánchez‐Martín et al.   FEBS Journal

Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells

(2018) Dongqing Zuo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1

(2018) Marisa Granato et al.   Viruses-Basel

EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis

(2018) Mara Cirone   Viruses-Basel

Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells

(2017) Roberta Gonnella et al.   FREE RADICAL BIOLOGY AND MEDICINE

A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis

(2017) Pin Liu et al.   HEPATOLOGY

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

(2017) Masahiro Morita et al.   MOLECULAR CELL

KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression

(2016) R. Santarelli et al.   Autophagy

High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin and p38 MAPK

(2016) Maria Saveria Gilardini Montani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt’s lymphoma

(2016) Marisa Granato et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth

(2016) Kuo-Hui Su et al.   NATURE CELL BIOLOGY

mTORC1 and mTORC2 in cancer and the tumor microenvironment

(2016) L C Kim et al.   ONCOGENE

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

The activation of KSHV lytic cycle blocks autophagy in PEL cells

(2015) Marisa Granato et al.   Autophagy

Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells

(2015) Marisa Granato et al.   CANCER LETTERS

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

(2015) Sharadha Dayalan Naidu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside

(2015) XueQiao Liu et al.   VIROLOGY

mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading

(2014) Tony D. Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Epstein-Barr Virus Blocks the Autophagic Flux and Appropriates the Autophagic Machinery To Enhance Viral Replication

(2014) M. Granato et al.   JOURNAL OF VIROLOGY

mTOR Inhibition Potentiates HSP90 Inhibitor Activity via Cessation of HSP Synthesis

(2014) Jaime Acquaviva et al.   MOLECULAR CANCER RESEARCH

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

Transcriptional regulation of the stress response by mTOR

(2014) J. Aramburu et al.   Science Signaling

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

4-Hydroxytamoxifen Induces Autophagic Death through K-Ras Degradation

(2013) L. Kohli et al.   CANCER RESEARCH

The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma

(2013) M. Chatterjee et al.   HAEMATOLOGICA

mTOR signaling for biological control and cancer

(2013) Anya Alayev et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line

(2013) Roberta Gonnella et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Macropinocytosis supports cancer cell proliferation

(2013) Maria Trajkovska   NATURE CELL BIOLOGY

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells

(2013) Marisa Granato et al.   PLoS One

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy

(2013) A Garufi et al.   Cell Death & Disease

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

COX-2/PGE2: molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP

(2012) N Sharma-Walia et al.   Oncogenesis

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells

(2010) Alfredo Toschi et al.   CANCER LETTERS

Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma

(2010) Jing Chen et al.   Journal of Translational Medicine

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The Role of Myc-Induced Protein Synthesis in Cancer

(2009) D. Ruggero   CANCER RESEARCH

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL