mTOR and Aging: An Old Fashioned Dress

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

(2018) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Disease or not, aging is easily treatable

(2018) Mikhail V. Blagosklonny   Aging-US

The Aging Cardiovascular System

(2017) Francesco Paneni et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Insights for Oxidative Stress and mTOR Signaling in Myocardial Ischemia/Reperfusion Injury under Diabetes

(2017) Dajun Zhao et al.   Oxidative Medicine and Cellular Longevity

Recognizing Degenerative Aging as a Treatable Medical Condition: Methodology and Policy

(2017) Ilia Stambler   Aging and Disease

Signaling Networks Determining Life Span

(2016) Celine E. Riera et al.   Annual Review of Biochemistry

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Aging of the immune system: Focus on inflammation and vaccination

(2016) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nuclear DNA damage signalling to mitochondria in ageing

(2016) Evandro Fei Fang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and Immune Senescence

(2016) Hanlin Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases

(2016) Valeria Conti et al.   Frontiers in Pharmacology

Validation of anti-aging drugs by treating age-related diseases

(2016) Mikhail V. Blagosklonny   Aging-US

The NADPH Oxidase Nox4 and Aging in the Heart

(2016) Tetsuro Ago et al.   Aging-US

mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors

(2016) Tingting Wu et al.   Scientific Reports

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes

(2015) Hae-Ok Byun et al.   BMB Reports

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

(2015) Stéphane Fourcade et al.   FREE RADICAL BIOLOGY AND MEDICINE

Klotho upregulation by rapamycin protects against vascular disease in CKD

(2015) Takayuki Hamano   KIDNEY INTERNATIONAL

NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis

(2015) Mariarosaria Santillo et al.   Frontiers in Physiology

Classifying aging as a disease in the context of ICD-11

(2015) Alex Zhavoronkov et al.   Frontiers in Genetics

It is time to classify biological aging as a disease

(2015) Sven Bulterijs et al.   Frontiers in Genetics

Should we treat aging as a disease? The consequences and dangers of miscategorisation

(2015) Richard G. A. Faragher   Frontiers in Genetics

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Geroconversion: irreversible step to cellular senescence

(2014) Mikhail V Blagosklonny   CELL CYCLE

Proinflammation of Aging Central Arteries: A Mini-Review

(2014) Mingyi Wang et al.   GERONTOLOGY

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

The Role of Klotho on Vascular Calcification and Endothelial Function in Chronic Kidney Disease

(2014) Marc G. Vervloet et al.   SEMINARS IN NEPHROLOGY

Characterization of novel markers of senescence and their prognostic potential in cancer

(2014) M Althubiti et al.   Cell Death & Disease

Natural CD8+CD122+ T Cells Are More Potent in Suppression of Allograft Rejection Than CD4+CD25+ Regulatory T Cells

(2013) Z. Dai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 -Dependent Glycolysis

(2013) G. Liu et al.   CANCER RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Infections in the Elderly

(2013) Hans Jürgen Heppner et al.   CRITICAL CARE CLINICS

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin induces ILT3 high ILT4 high dendritic cells promoting a new immunoregulatory pathway

(2013) Giovanni Stallone et al.   KIDNEY INTERNATIONAL

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Incidence and Risk of Treatment-Related Mortality with mTOR Inhibitors Everolimus and Temsirolimus in Cancer Patients: A Meta-Analysis

(2013) Wei-Xiang Qi et al.   PLoS One

Matched and mismatched metabolic fuels in lymphocyte function

(2013) Alfredo Caro-Maldonado et al.   SEMINARS IN IMMUNOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Kidney transplantation and the ageing immune system

(2012) Dianne McKay et al.   Nature Reviews Nephrology

Effects of Age and Heart Failure on Human Cardiac Stem Cell Function

(2011) Daniela Cesselli et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptional Control of Cellular Metabolism by mTOR Signaling

(2011) J. L. Yecies et al.   CANCER RESEARCH

mTOR signaling in protein homeostasis

(2011) Crystal S. Conn et al.   CELL CYCLE

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

Myeloid derived suppressor cells in transplantation

(2011) Jason R Lees et al.   CURRENT OPINION IN IMMUNOLOGY

Ischemic preconditioning: The role of mitochondria and aging

(2011) Andrew P. Wojtovich et al.   EXPERIMENTAL GERONTOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Physiologic Control of IDO Competence in Splenic Dendritic Cells

(2011) B. Baban et al.   JOURNAL OF IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

(2011) James B. Strait et al.   Heart Failure Clinics

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

Inflammation, aging, and cancer vaccines

(2010) Mauro Provinciali et al.   BIOGERONTOLOGY

The Biology of Aging and Frailty

(2010) Neal S. Fedarko   CLINICS IN GERIATRIC MEDICINE

CD8+ regulatory T cells in solid organ transplantation

(2010) Carole Guillonneau et al.   Current Opinion in Organ Transplantation

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Autophagy and amino acid homeostasis are required for chronological longevity inSaccharomyces cerevisiae

(2009) Ashley L. Alvers et al.   AGING CELL

Endotoxin-Induced Myeloid-Derived Suppressor Cells Inhibit Alloimmune Responses via Heme Oxygenase-1

(2009) V. De Wilde et al.   AMERICAN JOURNAL OF TRANSPLANTATION

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

(2009) David A. Guertin et al.   CANCER CELL

Impact of aging on cancer immunity and immunotherapy

(2009) Graham Pawelec et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Loss of cardioprotection with ageing

(2009) K. Boengler et al.   CARDIOVASCULAR RESEARCH

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

(2009) Regan M. Memmott et al.   CELLULAR SIGNALLING

Age-associated declines in immune system development and function: causes, consequences, and reversal

(2009) Kenneth Dorshkind et al.   CURRENT OPINION IN IMMUNOLOGY

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Common corruption of the mTOR signaling network in human tumors

(2009) S Menon et al.   ONCOGENE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy

(2008) C. Marcela Diaz-Montero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor Escape Mechanism Governed by Myeloid-Derived Suppressor Cells

(2008) S. Nagaraj et al.   CANCER RESEARCH

Telomere biology in heart failure

(2008) Liza S.M. Wong et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cancer Immunotherapy by Dendritic Cells

(2008) Cornelis J.M. Melief   IMMUNITY

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

(2008) Claudia Waskow et al.   NATURE IMMUNOLOGY

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

(2008) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Aging of the Immune System as a Prognostic Factor for Human Longevity

(2008) Anis Larbi et al.   PHYSIOLOGY

B Cell Immunosenescence in the Elderly and in Centenarians

(2008) Giuseppina Colonna-Romano et al.   REJUVENATION RESEARCH