IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by Promoting Cytokine Release and STAT3 Activation

Perturbation of bulk and selective macroautophagy, abnormal UPR activation and their interplay pave the way to immune dysfunction, cancerogenesis and neurodegeneration in ageing

(2020) Mara Cirone   AGEING RESEARCH REVIEWS

KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression

(2020) Maria Saveria Gilardini Montani et al.   BRITISH JOURNAL OF CANCER

Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

(2020) Gabriella D’Orazi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of the ER-Induced UPR Pathway and the Efficacy of Its Inhibitors and Inducers in the Inhibition of Tumor Progression

(2019) Anna Walczak et al.   Oxidative Medicine and Cellular Longevity

Role of Endoplasmic Reticulum Stress in the Anticancer Activity of Natural Compounds

(2019) Patrizia Limonta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

(2019) Mara Cirone et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Computational STAT3 activity inference reveals its roles in the pancreatic tumor microenvironment

(2019) Evelien Schaafsma et al.   Scientific Reports

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis

(2018) Mara Cirone   Viruses-Basel

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

(2017) Marisa Granato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeting the unfolded protein response in cancer

(2017) Rani Ojha et al.   PHARMACOLOGICAL RESEARCH

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

(2017) L. Masuelli et al.   OncoImmunology

High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin and p38 MAPK

(2016) Maria Saveria Gilardini Montani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

(2016) Michaël Cerezo et al.   CANCER CELL

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

(2016) Ciara M Gallagher et al.   eLife

The activation of KSHV lytic cycle blocks autophagy in PEL cells

(2015) Marisa Granato et al.   Autophagy

Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells

(2015) Marisa Granato et al.   CANCER LETTERS

Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival

(2014) Chih-Hang Anthony Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation

(2014) G. P. Meares et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy regulates inflammation following oxidative injury in diabetes

(2013) Yang Wang et al.   Autophagy

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells

(2013) Marisa Granato et al.   PLoS One

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma

(2013) M Granato et al.   Cell Death & Disease

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy

(2013) A Garufi et al.   Cell Death & Disease

The role of endoplasmic reticulum stress in maintaining and targeting multiple myeloma: a double-edged sword of adaptation and apoptosis

(2013) Shai White-Gilbertson et al.   Frontiers in Genetics

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma

(2010) K. A. Sarosiek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma

(2009) P Gasperini et al.   LEUKEMIA