Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy

(2015) Yu Matsuzawa et al.   Autophagy

Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart

(2015) Alex Morrison et al.   FASEB JOURNAL

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Autophagy-related prognostic signature for breast cancer

(2015) Yunyan Gu et al.   MOLECULAR CARCINOGENESIS

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy

(2015) L R Gomes et al.   ONCOGENE

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

(2015) Fabio Valenti et al.   Oncotarget

Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity

(2014) Elodie Viry et al.   BIOCHEMICAL PHARMACOLOGY

The cytoplasmic side of p53's oncosuppressive activities

(2014) Anna Comel et al.   FEBS LETTERS

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients

(2013) F. Ganci et al.   ANNALS OF ONCOLOGY

p53 in breast cancer subtypes and new insights into response to chemotherapy

(2013) Philippe Bertheau et al.   BREAST

Dissecting the pathways that destabilize mutant p53: The proteasome or autophagy?

(2013) Sujata Choundhury et al.   CELL CYCLE

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Autophagy regulation and its role in cancer

(2013) Séverine Lorin et al.   SEMINARS IN CANCER BIOLOGY

ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

(2013) Dipak Maskey et al.   Nature Communications

Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis

(2012) Claudia Fiorini et al.   APOPTOSIS

The rebel angel: mutant p53 as the driving oncogene in breast cancer

(2012) D. Walerych et al.   CARCINOGENESIS

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop

(2012) Fabio Valenti et al.   CELL CYCLE

miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours

(2012) Francesca Biagioni et al.   EMBO Molecular Medicine

Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: Evidence from a systematic review and meta-analysis

(2012) Jiangbo Liu et al.   EUROPEAN JOURNAL OF CANCER

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells

(2012) Toran Sanli et al.   PLoS One

TP53 genomics predict higher clinical and pathologic tumor response in operable early-stage breast cancer treated with docetaxel-capecitabine ± trastuzumab

(2011) Stefan Glück et al.   BREAST CANCER RESEARCH AND TREATMENT

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

(2010) Perry Stambolsky et al.   CANCER CELL

The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes

(2010) Ahmed M. Elsharkawy et al.   JOURNAL OF HEPATOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma

(2009) E Drakos et al.   LEUKEMIA

Endoplasmic reticulum stress and autophagy as targets for cancer therapy

(2008) Axel H. Schönthal   CANCER LETTERS

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL