Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

Combination Therapy of Chloroquine and C2-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells

(2019) Han-Lin Chou et al.   Cancers

The relationship between autophagy and the immune system and its applications for tumor immunotherapy

(2019) Guan-Min Jiang et al.   Molecular Cancer

Autophagy inhibition enhances PD-L1 expression in gastric cancer

(2019) Xiaojuan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer

(2019) Yuanliang Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression

(2019) Gabriella D’Orazi et al.   Cancers

Autophagy dysfunctions associated with cancer cells and their therapeutic implications

(2019) Aurelian Udristioiu et al.   BIOMEDICINE & PHARMACOTHERAPY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review

(2018) Jiang Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The autophagic network and cancer

(2018) Marissa D. Rybstein et al.   NATURE CELL BIOLOGY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

(2018) Mija Marinković et al.   Oxidative Medicine and Cellular Longevity

Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target

(2018) Ramona Schulz-Heddergott et al.   Cancers

EBV up-regulates PD-L1 on the surface of primary monocytes by increasing ROS and activating TLR signaling and STAT3

(2018) Maria Saveria Gilardini Montani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

The Roles of Autophagy in Cancer

(2018) Chul Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress

(2018) Maria Anele Romeo et al.   JOURNAL OF GENERAL VIROLOGY

UCP2 inhibition induces ROS/Akt/mTOR axis: Role of GAPDH nuclear translocation in genipin/everolimus anticancer synergism

(2017) Ilaria Dando et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

(2017) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

(2017) Marisa Granato et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

(2017) Marisa Granato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

(2017) Peng Liao et al.   MOLECULAR CELL

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation

(2017) Eunhee Kim et al.   PLoS Genetics

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

(2017) T Avril et al.   Oncogenesis

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

(2017) L. Masuelli et al.   OncoImmunology

Autophagy in Cancer Therapy

(2017) Simone Fulda   Frontiers in Oncology

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

(2017) Sharadha Dayalan Naidu et al.   Scientific Reports

Autophagy induction for the treatment of cancer

(2016) Federico Pietrocola et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression

(2016) R. Santarelli et al.   Autophagy

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt’s lymphoma

(2016) Marisa Granato et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Defective Autophagy Initiates Malignant Transformation

(2016) Lorenzo Galluzzi et al.   MOLECULAR CELL

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

(2016) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

PGE2 induced in and released by dying cells functions as an inhibitory DAMP

(2016) Sho Hangai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis

(2016) Atsushi Masui et al.   PLoS One

Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells

(2015) Thomas Condamine et al.   Annual Review of Medicine

Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells

(2015) Marisa Granato et al.   CANCER LETTERS

Heat Shock Factor 1 in Protein Homeostasis and Oncogenic Signal Integration

(2015) T. Home et al.   CANCER RESEARCH

Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

(2015) Kristin J. Lastwika et al.   CANCER RESEARCH

The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant

(2015) Kobe Reynders et al.   CANCER TREATMENT REVIEWS

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Zn(II)-curc targets p53 in thyroid cancer cells

(2015) ALESSIA GARUFI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells

(2015) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells

(2015) J M Bailey et al.   ONCOGENE

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

(2015) Sharadha Dayalan Naidu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications

(2015) S Baldari et al.   Cell Death & Disease

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Chloroquine-Enhanced Efficacy of Cisplatin in the Treatment of Hypopharyngeal Carcinoma in Xenograft Mice

(2015) Xing-guo Zhao et al.   PLoS One

High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity

(2014) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A gain-of-function mutant p53–HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress

(2014) D Li et al.   Cell Death & Disease

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

(2013) Yidan Wang et al.   Autophagy

4-Hydroxytamoxifen Induces Autophagic Death through K-Ras Degradation

(2013) L. Kohli et al.   CANCER RESEARCH

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Dendritic cells treated with chloroquine modulate experimental autoimmune encephalomyelitis

(2013) Rodolfo Thomé et al.   IMMUNOLOGY AND CELL BIOLOGY

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells

(2013) Marisa Granato et al.   PLoS One

Dendritic Cells: Master Regulators of the Immune Response

(2013) I. Mellman   Cancer Immunology Research

Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death

(2012) Isabelle Martins et al.   Autophagy

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation

(2012) Jisu Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91

(2012) Mara Cirone et al.   PLoS One

Targeting COX-2/PGE2 Pathway in HIPK2 Knockdown Cancer Cells: Impact on Dendritic Cell Maturation

(2012) Alessia Garufi et al.   PLoS One

Activation of dendritic cells by tumor cell death

(2012) Mara Cirone et al.   OncoImmunology

Colon tumour cells increase PGE2 by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation

(2011) H. R. Roberts et al.   CARCINOGENESIS

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Tumor Stress Inside Out: Cell-Extrinsic Effects of the Unfolded Protein Response in Tumor Cells Modulate the Immunological Landscape of the Tumor Microenvironment

(2011) N. R. Mahadevan et al.   JOURNAL OF IMMUNOLOGY

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

(2010) P. Isakson et al.   BLOOD

Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

(2010) Jie Li et al.   EUROPEAN JOURNAL OF CANCER

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL