RIPK3 blockade attenuates kidney fibrosis in a folic acid model of renal injury

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation

(2019) Shu Li et al.   EXPERIMENTAL CELL RESEARCH

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model

(2018) Orestes Foresto-Neto et al.   LABORATORY INVESTIGATION

Fluorofenidone attenuates interleukin-1β production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction

(2018) Linfeng Zheng et al.   NEPHROLOGY

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

(2018) Hsiao-Huei Chen et al.   Neural Regeneration Research

FDA Approval Summary: Dabrafenib and Trametinib for the Treatment of Metastatic Non‐Small Cell Lung Cancers HarboringBRAF V600EMutations

(2018) Lauretta Odogwu et al.   ONCOLOGIST

Necroptosis in 3-chloro-1, 2-propanediol (3-MCPD)-dipalmitate-induced acute kidney injury in vivo and its repression by miR-223-3p

(2018) Guoren Huang et al.   TOXICOLOGY

Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1

(2018) Nai-jun Miao et al.   ACTA PHARMACOLOGICA SINICA

Mechanisms of RIPK3-induced inflammation

(2017) Inbar Shlomovitz et al.   IMMUNOLOGY AND CELL BIOLOGY

Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease

(2017) Steven G. Coca et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation

(2017) Shaofei Wang et al.   Cell Death & Disease

The intersection of cell death and inflammasome activation

(2016) James E. Vince et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration

(2016) Casimiro Gerarduzzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

(2016) Diego Martin-Sanchez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

RIPK3-Mediated Necroptosis and Apoptosis Contributes to Renal Tubular Cell Progressive Loss and Chronic Kidney Disease Progression in Rats

(2016) Yongjun Zhu et al.   PLoS One

Biomarkers of renal function, which and when?

(2015) Michael E. Wasung et al.   CLINICA CHIMICA ACTA

Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury

(2015) Alaa S. Awad et al.   KIDNEY INTERNATIONAL

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma

(2015) Francesco Spagnolo et al.   Oncotarget

Population pharmacokinetics of dabrafenib, a BRAF inhibitor: Effect of dose, time, covariates, and relationship with its metabolites

(2014) Daniele Ouellet et al.   JOURNAL OF CLINICAL PHARMACOLOGY

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

Nlrp3 Prevents Early Renal Interstitial Edema and Vascular Permeability in Unilateral Ureteral Obstruction

(2014) Wilco P. Pulskens et al.   PLoS One

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

(2014) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

(2014) J-X Li et al.   Cell Death & Disease

RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival

(2013) A. Lau et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concomitant Oral and Intravenous Pharmacokinetics of Dabrafenib, a BRAF Inhibitor, in Patients with BRAF V600 Mutation-Positive Solid Tumors

(2013) Cathrine L. Denton et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Macrophages promote polycystic kidney disease progression

(2013) Katherine I Swenson-Fields et al.   KIDNEY INTERNATIONAL

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Suppressed mitochondrial biogenesis in folic acid-induced acute kidney injury and early fibrosis

(2013) L. Jay Stallons et al.   TOXICOLOGY LETTERS

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Inflammasome-Independent NLRP3 Augments TGF-  Signaling in Kidney Epithelium

(2012) W. Wang et al.   JOURNAL OF IMMUNOLOGY

The role of EMT in renal fibrosis

(2011) Rosemarie M. Carew et al.   CELL AND TISSUE RESEARCH

Mortality from diabetic renal disease: a hidden epidemic

(2011) C. Rao et al.   EUROPEAN JOURNAL OF PUBLIC HEALTH

Fibroblasts and myofibroblasts in renal fibrosis

(2011) Soma Meran et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis

(2011) B. Buchholz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Morphometric and Visual Evaluation of Fibrosis in Renal Biopsies

(2010) A. B. Farris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanistic connection between inflammation and fibrosis

(2010) Soo Bong Lee et al.   KIDNEY INTERNATIONAL

Macrophages and Immunologic Inflammation of the Kidney

(2010) Jeremy S. Duffield   SEMINARS IN NEPHROLOGY