The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?

Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics

(2020) Luke Cassidy et al.   COMPLEMENTARY THERAPIES IN MEDICINE

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Small RNAs in eucaryotes: new clues for amplifying microRNA benefits

(2020) Bernardetta Ledda et al.   Cell and Bioscience

PNU282987 inhibits amyloid‑β aggregation by upregulating astrocytic endogenous αB‑crystallin and HSP‑70 via regulation of the α7AChR, PI3K/Akt/HSF‑1 signaling axis

(2020) Zhenkui Ren et al.   Molecular Medicine Reports

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway

(2020) Shih-Chang Fu et al.   TOXICOLOGY IN VITRO

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho

(2019) Lixia Ye et al.   EXPERIMENTAL NEUROLOGY

Emerging Signal Regulating Potential of Genistein Against Alzheimer’s Disease: A Promising Molecule of Interest

(2019) Md. Sahab Uddin et al.   Frontiers in Cell and Developmental Biology

NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

(2019) Paula Maria Quaglio Bellozi et al.   Frontiers in Pharmacology

Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases

(2019) Alain Couvineau et al.   Frontiers in Endocrinology

Melatonin protects against Aβ-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway

(2018) Yue Zhao et al.   BIOFACTORS

Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxins 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer’s Disease

(2018) Shohreh Majd et al.   Current Alzheimer Research

The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

(2018) Ratan V. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Harpagoside Rescues the Memory Impairments in Chronic Cerebral Hypoperfusion Rats by Inhibiting PTEN Activity

(2018) Chen Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells

(2018) Hae Seong Song et al.   PHYTOMEDICINE

Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway

(2018) Shanshan Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytic α7 Nicotinic Receptor Activation Inhibits Amyloid-β Aggregation by Upregulating Endogenous αB-crystallin through the PI3K/Akt Signaling Pathway

(2018) Zhenkui Ren et al.   Current Alzheimer Research

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

High salt diet impairs memory-related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expression

(2017) Qian Ge et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-β1–42 in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K/Akt/Nrf2 Pathway

(2017) Yang Hui et al.   NEUROCHEMICAL RESEARCH

Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus

(2017) Xiaoyu Song et al.   PHYSIOLOGY & BEHAVIOR

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models

(2017) Kazuo Umezawa et al.   Human Cell

Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells

(2017) et al.   Nutrients

GSK-3 Inhibitors: A Ray of Hope for the Treatment of Alzheimer's Disease?

(2017) Ana Martinez et al.   JOURNAL OF ALZHEIMERS DISEASE

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Dihydrocapsaicin Attenuates Blood Brain Barrier and Cerebral Damage in Focal Cerebral Ischemia/Reperfusion via Oxidative Stress and Inflammatory

(2017) Adchara Janyou et al.   Scientific Reports

Inverse relationship between Alzheimer’s disease and cancer, and other factors contributing to Alzheimer’s disease: a systematic review

(2016) Ovais Shafi   BMC Neurology

β-asarone improves learning and memory and reduces Acetyl Cholinesterase and Beta-amyloid 42 levels in APP/PS1 transgenic mice by regulating Beclin-1-dependent autophagy

(2016) Minzhen Deng et al.   BRAIN RESEARCH

NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

(2016) J Haslund-Vinding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

Neuregulin-1 attenuates cognitive function impairments in a transgenic mouse model of Alzheimer’s disease

(2016) J Ryu et al.   Cell Death & Disease

Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment

(2016) Paula Maria Quaglio Bellozi et al.   Scientific Reports

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

Insulin resistance predicts brain amyloid deposition in late middle-aged adults

(2015) Auriel A. Willette et al.   Alzheimers & Dementia

Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update

(2015) Melissa A. Bradley-Whitman et al.   ARCHIVES OF TOXICOLOGY

The Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral Infarction

(2015) Seong-Ho Koh et al.   Journal of Clinical Neurology

Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease

(2015) Yuqi Zeng et al.   JOURNAL OF NEUROCHEMISTRY

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

(2014) Anna Mietelska-Porowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C. elegans

(2014) Yuli Volovik et al.   Cell Reports

Environmental factors and unhealthy lifestyle influence oxidative stress in humans—an overview

(2013) G. Smilin Bell Aseervatham et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Amyloid-  Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3  in Primary Cultured Hippocampal Neurons

(2013) H. Decker et al.   JOURNAL OF NEUROSCIENCE

Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both  -Amyloid Production and Clearance

(2013) Z. Zhu et al.   JOURNAL OF NEUROSCIENCE

Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

(2013) Chong Wang et al.   MOLECULAR NEUROBIOLOGY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation

(2013) Yue Wang et al.   PHYTOMEDICINE

Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

(2013) Ida Annunziata et al.   Nature Communications

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

mTOR inhibitors in cancer therapy

(2012) Yekaterina Y. Zaytseva et al.   CANCER LETTERS

Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer

(2012) Bhupendra Singh et al.   CARCINOGENESIS

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Does Lithium Prevent Alzheimerʼs Disease?

(2012) Orestes V. Forlenza et al.   DRUGS & AGING

Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies

(2012) D. Mahadevan et al.   EUROPEAN JOURNAL OF CANCER

Glycogen synthase kinase-3β regulates anti-inflammatory property of fluoxetine

(2012) Hui-Chen Su et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hypolipidemic Activity in Sprague-Dawley Rats and Constituents of a Novel Natural Vegetable Oil from Cornus Wilsoniana Fruits

(2012) Jie Fu et al.   JOURNAL OF FOOD SCIENCE

The Early Activation of PI3K Strongly Enhances the Resistance of Cortical Neurons to Hypoxic Injury via the Activation of Downstream Targets of the PI3K Pathway and the Normalization of the Levels of PARP Activity, ATP, and NAD+

(2012) Min Young Noh et al.   MOLECULAR NEUROBIOLOGY

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

Genistein Inhibits Aβ25–35 –Induced Neurotoxicity in PC12 Cells via PKC Signaling Pathway

(2012) Sijing Luo et al.   NEUROCHEMICAL RESEARCH

Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-κB activation in a cerebral ischemia mouse model

(2012) Yisong Qian et al.   NEUROCHEMISTRY INTERNATIONAL

Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation

(2011) Sarah L. Shammas et al.   BIOPHYSICAL JOURNAL

Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics and neuronal synaptic damage in neurodegenerative diseases

(2011) T Nakamura et al.   CELL DEATH AND DIFFERENTIATION

α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes

(2011) Kévin Ragot et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway

(2011) Di Wang et al.   JOURNAL OF BIOSCIENCES

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

(2011) Hemachander Capiralla et al.   JOURNAL OF NEUROCHEMISTRY

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling

(2011) J C Garza et al.   MOLECULAR PSYCHIATRY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

An Active Fraction of Achyranthes bidentata Polypeptides Prevents Apoptosis Induced by Serum Deprivation in SH-SY5Y Cells Through Activation of PI3K/Akt/Gsk3β Pathways

(2011) Yuntian Shen et al.   NEUROCHEMICAL RESEARCH

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y

(2011) N. Xiong et al.   NEUROSCIENCE

Amyloid-β Production: Major Link Between Oxidative Stress and BACE1

(2011) Elena Tamagno et al.   NEUROTOXICITY RESEARCH

Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation

(2011) H Je et al.   Molecular Brain

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway

(2010) G.D. Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: Possible pharmacological strategies

(2010) Tomohiro Nakamura et al.   CELL CALCIUM

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

(2010) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR

(2010) Atsushi Sato et al.   NEUROSCIENCE LETTERS

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

Dissecting the role of mTOR: Lessons from mTOR inhibitors

(2009) Ryan J.O. Dowling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chemically Inducible Inactivation of Protein Synthesis in Genetically Targeted Neurons

(2009) H.-S. Je et al.   JOURNAL OF NEUROSCIENCE

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Chaperone signalling complexes in Alzheimer's disease

(2008) John Koren et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Thematic Review Series: Sphingolipids.Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease—a review,

(2008) Toshio Ariga et al.   JOURNAL OF LIPID RESEARCH

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

(2008) Elisabete Ferreiro et al.   NEUROBIOLOGY OF DISEASE

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Lithium down-regulates tau in cultured cortical neurons: A possible mechanism of neuroprotection

(2008) A. Rametti et al.   NEUROSCIENCE LETTERS

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

(2008) Young-Joon Surh et al.   PLANTA MEDICA

Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3

(2007) Seong-Ho Koh et al.   BRAIN RESEARCH

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia

(2007) Guizhi Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING