NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

Glial activation and inflammation along the Alzheimer’s disease continuum

(2019) Kaja Nordengen et al.   Journal of Neuroinflammation

Reactive astrocytes in Alzheimer’s disease: A double-edged sword

(2018) Heejung Chun et al.   NEUROSCIENCE RESEARCH

Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative

(2018) Victoria Navarro et al.   Frontiers in Aging Neuroscience

Expression Profiles of Cytokines in the Brains of Alzheimer's Disease (AD) Patients Compared to the Brains of Non-Demented Patients with and without Increasing AD Pathology

(2018) Kaori Morimoto et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid

(2017) Soraya Wilke Saliba et al.   Journal of Neuroinflammation

Astrocyte and Alzheimer’s disease

(2017) Zhiyou Cai et al.   JOURNAL OF NEUROLOGY

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Mechanisms of Alzheimer’s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors

(2017) Sayad Kocahan et al.   Clinical Psychopharmacology and Neuroscience

Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance

(2016) Xiao-dan Guo et al.   ACTA PHARMACOLOGICA SINICA

Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages

(2016) Michael L. Lehmann et al.   Journal of Neuroinflammation

Balancing the immune response in the brain: IL-10 and its regulation

(2016) Diogo Lobo-Silva et al.   Journal of Neuroinflammation

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

(2016) Dheeraj S. Roy et al.   NATURE

Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia

(2016) Y.L. Chen et al.   NEUROSCIENCE

Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms

(2016) Fan Su et al.   Neuroscience Bulletin

Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment

(2016) Paula Maria Quaglio Bellozi et al.   Scientific Reports

The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

(2016) Cong Zheng et al.   Translational Neurodegeneration

Glio-vascular changes during ageing in wild-type and Alzheimer׳s disease-like APP/PS1 mice

(2015) C.S. Janota et al.   BRAIN RESEARCH

Aβ42 oligomers selectively disrupt neuronal calcium release

(2015) Cristian Lazzari et al.   NEUROBIOLOGY OF AGING

The Effect of Aβ1-42 Oligomers on APP Processing and Aβ1-40 Generation in Cultured U-373 Astrocytes

(2015) Dimitar Ourdev et al.   Neurodegenerative Diseases

Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: Positive clue toward SAD

(2015) P. Moorthi et al.   NEUROSCIENCE

The Effects of Soluble A.β Oligomers on Neurodegeneration in Alzheimer's Disease

(2015) Jonathan Brouillette   CURRENT PHARMACEUTICAL DESIGN

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

(2015) Bipasha Mukherjee et al.   NEOPLASIA

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not  -Amyloid in Cognitively Normal Older Individuals

(2013) M. Wirth et al.   JOURNAL OF NEUROSCIENCE

Genetic mouse models of brain ageing and Alzheimer's disease

(2013) Andras Bilkei-Gorzo   PHARMACOLOGY & THERAPEUTICS

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine

(2012) C. Romberg et al.   BRAIN

Neuroinflammation, Neurodegeneration, and Depression

(2012) Laura L. Hurley et al.   NEUROTOXICITY RESEARCH

Thy1-hAPPLond/Swe+mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

(2012) Mehrdad Faizi et al.   Brain and Behavior

Whole Animal Perfusion Fixation for Rodents

(2012) Gregory J. Gage et al.   Jove-Journal of Visualized Experiments

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Design-based Stereology

(2010) Rogely Waite Boyce et al.   TOXICOLOGIC PATHOLOGY

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Involvement of phosphoinositide 3-kinase γ in the neuro-inflammatory response and cognitive impairments induced by β-amyloid 1–40 peptide in mice

(2009) Giselle F. Passos et al.   BRAIN BEHAVIOR AND IMMUNITY

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS