NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

The Redox Code

(2015) Dean P. Jones et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

(2015) Kazufumi Hirano et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants in Translational Medicine

(2015) Harald H.H.W. Schmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications

(2015) Ana I. Casas et al.   ANTIOXIDANTS & REDOX SIGNALING

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models

(2015) Qingshan Wang et al.   BRAIN

The Concise Guide to PHARMACOLOGY 2015/16: Ligand-gated ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

Effects of inflammation on stem cells: together they strive?

(2015) C. Kizil et al.   EMBO REPORTS

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

(2015) Weihua Zhao et al.   EXPERIMENTAL NEUROLOGY

A subset of N-substituted phenothiazines inhibits NADPH oxidases

(2015) Tamara Seredenina et al.   FREE RADICAL BIOLOGY AND MEDICINE

The cysteine proteome

(2015) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Microglia on Neurogenesis

(2015) Kaoru Sato   GLIA

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Receptors, Ion Channels, and Signaling Mechanisms Underlying Microglial Dynamics

(2015) Christian Madry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effects of N-acetylcysteine amide on experimental focal penetrating brain injury in rats

(2015) Mattias Günther et al.   JOURNAL OF CLINICAL NEUROSCIENCE

P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

(2015) Tianfang Jiang et al.   NEUROBIOLOGY OF AGING

Activation of mGluR5 Attenuates Microglial Activation and Neuronal Apoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats

(2015) Zong-yong Zhang et al.   NEUROCHEMICAL RESEARCH

α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation

(2015) Shijun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase

(2015) Yang Li et al.   ACS Medicinal Chemistry Letters

Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis

(2015) Mariko Hara-Chikuma et al.   Nature Communications

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

(2015) Miguel Angel Burguillos et al.   Cell Reports

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

The interaction between microglia and neural stem/precursor cells

(2014) Peng Su et al.   BRAIN RESEARCH BULLETIN

Positive Allosteric Modulators (PAMs) of Metabotropic Glutamate Receptor 5 (mGluR5) Attenuate Microglial Activation

(2014) Fengtian Xue et al.   CNS & Neurological Disorders-Drug Targets

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

(2014) Qingshan Wang et al.   GLIA

NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases

(2014) Balázs Rada et al.   INFLAMMATION RESEARCH

High-throughput Assays for Superoxide and Hydrogen Peroxide

(2014) Jacek Zielonka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

Potent Anti-Inflammatory and Neuroprotective Effects of TGF- 1 Are Mediated through the Inhibition of ERK and p47phox-Ser345 Phosphorylation and Translocation in Microglia

(2014) L. Qian et al.   JOURNAL OF IMMUNOLOGY

Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells

(2014) Boonrat Chantong et al.   Journal of Neuroinflammation

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage

(2014) Zhao Yang et al.   MOLECULAR IMMUNOLOGY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

(2014) David J. Loane et al.   Neurotherapeutics

Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

(2014) Nilesh M. Agalave et al.   PAIN

Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles

(2014) Xiaoming Hu et al.   PROGRESS IN NEUROBIOLOGY

Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex

(2014) Benedetta Arnò et al.   Nature Communications

The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis

(2014) Silvia Sorce et al.   PLoS Pathogens

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2

(2013) Guadalupe Martel-Gallegos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

(2013) Gerd P. Bienert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Interaction of NADPH oxidase 1 with Toll-like receptor 2 induces migration of smooth muscle cells

(2013) Jee Hyun Lee et al.   CARDIOVASCULAR RESEARCH

The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex

(2013) Aurélia Lelli et al.   GLIA

The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis

(2013) S. Apolloni et al.   JOURNAL OF IMMUNOLOGY

The Tumor Suppressor p53 Fine-Tunes Reactive Oxygen Species Levels and Neurogenesis via PI3 Kinase Signaling

(2013) K. Forsberg et al.   JOURNAL OF NEUROSCIENCE

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Microglial Cells Are Involved in the Susceptibility of NADPH Oxidase Knockout Mice to 6-Hydroxy-Dopamine-Induced Neurodegeneration

(2013) Marina S. Hernandes et al.   PLoS One

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

Redox Biology on the rise

(2012) Johannes M. Herrmann et al.   BIOLOGICAL CHEMISTRY

Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase

(2012) Eun Sook Chung et al.   BRAIN RESEARCH

VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression

(2012) Erzsebet Kokovay et al.   Cell Stem Cell

TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

(2012) Shai Abutbul et al.   GLIA

Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx

(2012) Bettina Linnartz et al.   GLIA

Receptor Signaling Lymphocyte-activation Molecule Family 1 (Slamf1) Regulates Membrane Fusion and NADPH Oxidase 2 (NOX2) Activity by Recruiting a Beclin-1/Vps34/Ultraviolet Radiation Resistance-associated Gene (UVRAG) Complex

(2012) Chunyan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD11b/CD18 (Mac-1) Is a Novel Surface Receptor for Extracellular Double-Stranded RNA To Mediate Cellular Inflammatory Responses

(2012) H. Zhou et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Slamf8 Is a Negative Regulator of Nox2 Activity in Macrophages

(2012) G. Wang et al.   JOURNAL OF IMMUNOLOGY

Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions

(2012) Emma L. Mead et al.   JOURNAL OF NEUROCHEMISTRY

Nucleotides released from Aβ1-42-treated microglial cells increase cell migration and Aβ1-42 uptake through P2Y2 receptor activation

(2012) Hye Jung Kim et al.   JOURNAL OF NEUROCHEMISTRY

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91 phox subunit of NADPH oxidase

(2012) Qingshan Wang et al.   Journal of Neuroinflammation

NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury

(2012) W. Kallenborn-Gerhardt et al.   JOURNAL OF NEUROSCIENCE

Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/ -Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair

(2012) F. L'Episcopo et al.   JOURNAL OF NEUROSCIENCE

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

(2012) B. Linnartz et al.   JOURNAL OF NEUROSCIENCE

Attenuation of Microglial Activation with Minocycline Is Not Associated with Changes in Neurogenesis after Focal Traumatic Brain Injury in Adult Mice

(2012) Si Yun Ng et al.   JOURNAL OF NEUROTRAUMA

Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

(2012) David J. Loane et al.   JOURNAL OF NEUROTRAUMA

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes

(2012) J.V. Berger et al.   NEUROSCIENCE

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

(2012) Hui-Ming Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia

(2012) Yukiya Suzuki et al.   Scientific Reports

Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia

(2011) Yingqian Huo et al.   BMC NEUROSCIENCE

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

(2011) Vincent Jaquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke

(2011) Ursula Heldmann et al.   EXPERIMENTAL NEUROLOGY

Neuroglia, der lebende Nervenkitt

(2011) H. Kettenmann et al.   FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE

Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia

(2011) Youichirou Higashi et al.   GLIA

NADPH Oxidase Is Internalized by Clathrin-coated Pits and Localizes to a Rab27A/B GTPase-regulated Secretory Compartment in Activated Macrophages

(2011) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation

(2011) Gregory J. Gatto et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst

(2011) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Aspirin Protects Dopaminergic Neurons Against Lipopolysaccharide-Induced Neurotoxicity in Primary Midbrain Cultures

(2011) Fang Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Clozapine Protects Dopaminergic Neurons from Inflammation-Induced Damage by Inhibiting Microglial Overactivation

(2011) Xiaoming Hu et al.   Journal of Neuroimmune Pharmacology

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Effects of Edaravone, a Free Radical Scavenger, on Serum Levels of Inflammatory Biomarkers in Acute Brain Infarction

(2011) Kenji Isahaya et al.   Journal of Stroke & Cerebrovascular Diseases

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells

(2011) Guy C. Brown et al.   MITOCHONDRION

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

(2011) Olga V. Chechneva et al.   NEUROBIOLOGY OF DISEASE

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

(2010) K. E. Anderson et al.   BLOOD

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation

(2010) Yuxin Liu et al.   NEUROPHARMACOLOGY

Brain injury activates microglia that induce neural stem cell proliferation ex vivo and promote differentiation of neurosphere-derived cells into neurons and oligodendrocytes

(2010) T. Deierborg et al.   NEUROSCIENCE

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Key Role of CD36 in Toll-Like Receptor 2 Signaling in Cerebral Ischemia

(2010) Takato Abe et al.   STROKE

Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation

(2010) Yi Feng et al.   PLOS BIOLOGY

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

(2009) Jamel El-Benna et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

(2009) David J. Loane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase 2 Interaction with TLR2 Is Required for Efficient Innate Immune Responses to Mycobacteria via Cathelicidin Expression

(2009) C.-S. Yang et al.   JOURNAL OF IMMUNOLOGY

NOX4 Expression in Human Microglia Leads to Constitutive Generation of Reactive Oxygen Species and to Constitutive IL-6 Expression

(2009) Bin Li et al.   Journal of Innate Immunity

NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

(2009) H. Girouard et al.   JOURNAL OF NEUROSCIENCE

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Structural Insights into Nox4 and Nox2: Motifs Involved in Function and Cellular Localization

(2009) K. von Lohneysen et al.   MOLECULAR AND CELLULAR BIOLOGY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Identification of Structural Elements in Nox1 and Nox4 Controlling Localization and Activity

(2008) Ina Helmcke et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons

(2008) Wen Ji Yuan et al.   BMC NEUROSCIENCE

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar β amyloid peptide (1-42)-stimulated microglia

(2008) Ju Hyun Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases

(2008) Avik Roy et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia

(2008) Emanuele Cacci et al.   GLIA

Expression of Amyotrophic Lateral Sclerosis-linked SOD1 Mutant Increases the Neurotoxic Potential of Microglia via TLR2

(2008) Yang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases

(2008) Timothy J. Harrigan et al.   JOURNAL OF NEUROCHEMISTRY

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

(2008) S. Wakselman et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-β1-42

(2008) Juefei Zhou et al.   JOURNAL OF PINEAL RESEARCH

Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS

(2008) J. Rodriguez-Pallares et al.   NEUROBIOLOGY OF DISEASE

Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation

(2008) Yachen Li et al.   NEUROPHARMACOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling

(2007) Chul-Su Yang et al.   CELLULAR MICROBIOLOGY

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION