Article
Cell Biology
Elise Marechal, Anne Poliard, Kilian Henry, Mathias Moreno, Mathilde Legrix, Nicolas Macagno, Gregoire Mondielli, Teddy Fauquier, Anne Barlier, Heather C. Etchevers
Summary: Recurrent missense mutations of the PIK3CA oncogene are common drivers of human cancers. These mutations lead to constitutive activation of the p110 alpha subunit, resulting in a broad range of cancers and related disorders. Activation of PI3K signaling within endothelial cells causes vascular malformations, while neural crest cells and related lineages are affected in PIK3CA-related disorders. The study found that Pik3ca-mutant neural crest cells are associated with cephalic vascular anomalies, and constitutive Pik3ca activity affects the development of vascular connective tissues. Schwann cell precursors with PI3K activation are also linked to vascular and other tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Arianna Baggiolini, Scott J. Callahan, Emily Montal, Joshua M. Weiss, Tuan Trieu, Mohita M. Tagore, Sam E. Tischfield, Ryan M. Walsh, Shruthy Suresh, Yujie Fan, Nathaniel R. Campbell, Sarah C. Perlee, Nathalie Saurat, Miranda Hunter, Theresa Simon-Vermot, Ting-Hsiang Huang, Yilun Ma, Travis Hollmann, Satish K. Tickoo, Barry S. Taylor, Ekta Khurana, Richard P. Koche, Lorenz Studer, Richard M. White
Summary: The intrinsic transcriptional program present in the cell of origin plays a key role in the transforming ability of oncogenes like BRAF(V600E), with developmental chromatin factors mediating oncogenic competence and allowing for proper response to oncogenes.
Article
Neurosciences
Sheng Zhang, Yan Wang, Jie Xu, Bokyung Kim, Wenbin Deng, Fuzheng Guo
Summary: This study reveals the important role of HIF-alpha in developmental myelination, demonstrating its requirement in controlling OPC differentiation for efficient myelination. Contrary to previous beliefs, it was found that HIF-alpha's regulation of CNS myelination is independent of canonical Wnt signaling, and instead involves the HIF-alpha-Sox9 regulatory axis. This discovery represents a shift in understanding the mechanisms of HIF-alpha-regulated CNS myelination from a Wnt-dependent view to a Wnt-independent one.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Cell Biology
Bahare Shokouhian, Hamidreza Aboulkheyr Es, Babak Negahdari, Atena Tamimi, Maryam Shahdoust, Anastasia Shpichka, Peter Timashev, Moustapha Hassan, Massoud Vosough
Summary: Development is a complex process involving cell differentiation, and understanding the similarities in gene expression profiles between malignant and undifferentiated cells is crucial. Hepatocellular carcinoma (HCC) is a prevalent cancer with limited treatment options, and targeting common signaling pathways in liver development and HCC could provide a rational therapeutic approach.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Psychology, Educational
David C. Geary, Mary K. Hoard, Lara Nugent, Zehra E. Unal
Summary: This study found that boys and girls showed similar patterns of mathematical development from sixth to ninth grade, but spatial abilities were relatively more important for boys, while in-class attention was relatively more important for girls.
JOURNAL OF EDUCATIONAL PSYCHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chiara Mazziotta, Carmen Lanzillotti, Maria Rosa Iaquinta, Francesca Taraballi, Elena Torreggiani, John Charles Rotondo, Lucia Oton-Gonzalez, Elisa Mazzoni, Francesca Frontini, Ilaria Bononi, Monica De Mattei, Mauro Tognon, Fernanda Martini
Summary: MSCs are important source for bone regeneration and play a crucial role in osteogenic differentiation. MiRNAs regulate gene expression in osteogenic differentiation of MSCs and are involved in controlling important signaling pathways such as TGF-beta/BMP and Wnt/beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Kristijan Pazur, Ioannis Giannios, Mathias Lesche, Eva Rodriguez-Aznar, Anthony Gavalas
Summary: Hoxb1 plays different roles in neuromesodermal progenitors and hindbrain neural progenitors, promoting survival and specifying neural cell differentiation through regulation of Fgf signaling and synergistic interaction with shh. This highlights the potential of Hox genes in guiding cell specification and transplantation for neurodegenerative diseases.
Review
Plant Sciences
Cheng Jiang, Jiawei Wang, Hua-Ni Leng, Xiaqin Wang, Yijing Liu, Haiwen Lu, Meng-Zhu Lu, Jin Zhang
Summary: Developmental programmed cell death (dPCD) plays crucial roles in plant growth and development, especially in industrial production. Despite the identification of key regulators, the complex molecular networks controlling plant dPCD and its original triggers remain elusive.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Irene Blo, Simona Salati, Matteo Cadossi, Monica De Mattei
Summary: Mesenchymal stem cells play a crucial role in tissue engineering, but their therapeutic application is still debated; pulsed electromagnetic fields are used to enhance bone healing and protect joints, promoting osteogenic and chondrogenic differentiation of MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Elza Evren, Emma Ringqvist, Kumar Parijat Tripathi, Natalie Sleiers, Ines Co Rives, Arlisa Alisjahbana, Yu Gao, Dhifaf Sarhan, Tor Halle, Chiara Sorini, Rico Lepzien, Nicole Marquardt, Jakob Michaelsson, Anna Smed-Sorensen, Johan Botling, Mikael C. Karlsson, Eduardo J. Villablanca, Tim Willinger
Summary: This study investigates the development of lung macrophages from human hematopoiesis using a humanized mouse model. The results show that different types of blood monocytes generate macrophages in distinct anatomical niches in the lung. Additionally, single-cell RNA sequencing reveals intermediate differentiation stages in human lung macrophage development.
Review
Neurosciences
Yong-mei Zhang, Ying-bei Qi, Ya-nan Gao, Wen-gang Chen, Ting Zhou, Yi Zang, Jia Li
Summary: Astrocytes, comprising a large portion of cells in the central nervous system, play a crucial role in maintaining metabolic balance. Dysfunction in astrocyte metabolism has been identified as a major cause of neurological disorders including depression, Alzheimer's disease, and epilepsy. The metabolism of glucose, amino acids, and lipids in astrocytes has been implicated in the development of neurological diseases. This review provides an overview of the metabolic processes in astrocytes, focusing on glucose, fatty acid, and amino acid metabolism, and discusses their implications in neurological disorders.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Immunology
Jingyue Li, Mingjiu Zhao, Wenjun Luo, Jiaqi Huang, Bin Zhao, Zhiguang Zhou
Summary: Autoimmune diseases result from the immune system's failure to distinguish self-antigens from foreign ones. B lymphocytes play a crucial role in autoimmune disorders by producing autoantibodies and pro-inflammatory cytokines. Metabolic dysregulation in B cell function disrupts immune regulation and leads to autoimmune diseases. This review summarizes the latest research on metabolic reprogramming of B lymphocytes in autoimmune diseases, identifies key pathways and regulatory factors, and considers metabolic interventions as potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohammed A. Basar, David B. Beck, Achim Werner
Summary: Metazoan development from a one-cell zygote to a fully formed organism requires complex cellular differentiation and communication pathways. To coordinate these processes, embryos frequently encode signaling information with the small protein modifier ubiquitin, which is typically attached to lysine residues within substrates. DUBs, a class of similar to 100 human enzymes, critically regulate ubiquitin signaling and control many essential cellular functions and various aspects of human physiology and development. Recent genetic studies have identified mutations in several DUBs that cause developmental disorders.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
In-Young Jung, Robert L. Bartoszek, Andrew J. Rech, Sierra M. Collins, Soon-Keat Ooi, Erik F. Williams, Caitlin R. Hopkins, Vivek Narayan, Naomi B. Haas, Noelle V. Frey, Elizabeth O. Hexner, Donald L. Siegel, Gabriela Plesa, David L. Porter, Adrian Cantu, John K. Everett, Sonia Guedan, Shelley L. Berger, Frederic D. Bushman, Friederike Herbst, Joseph A. Friederike
Summary: CAR T cell therapy has shown potential in treating hematologic cancers but is limited in solid tumors. Chronic stimulation of CAR T cells propagates inhibitory type I interferon signaling, hindering antitumor function. Knocking out the EGR2 transcriptional regulator improves CAR T cell efficacy and blocks interferon-induced dysfunction. The gene signature of EGR2 is a biomarker for CAR T cell failure and patient survival. Modulating CAR T cell-intrinsic resistance is crucial for improving therapy outcomes.
Article
Biochemistry & Molecular Biology
Jeyoung Bang, Minguk Han, Tack-Jin Yoo, Lu Qiao, Jisu Jung, Jiwoon Na, Bradley A. Carlson, Vadim N. Gladyshev, Dolph L. Hatfield, Jin-Hong Kim, Lark Kyun Kim, Byeong Jae Lee
Summary: SEPHS1 deficiency causes a gradual increase in oxidative stress, which alters signaling pathways during gastrulation and ultimately leads to apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lewis D. Evans, Thomas Wassmer, Graham Fraser, James Smith, Michael Perkinton, Andrew Billinton, Frederick J. Livesey
Article
Cell Biology
Kei Miyamoto, Khoi T. Nguyen, George E. Allen, Jerome Jullien, Dinesh Kumar, Tomoki Otani, Charles R. Bradshaw, Frederick J. Livesey, Manolis Kellis, John B. Gurdon
Article
Cell & Tissue Engineering
Philip W. Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J. Livesey
Article
Cell & Tissue Engineering
Viola Volpato, James Smith, Cynthia Sandor, Janina S. Ried, Anna Baud, Adam Handel, Sarah E. Newey, Frank Wessely, Moustafa Attar, Emma Whiteley, Satyan Chintawar, An Verheyen, Thomas Barta, Majlinda Lako, Lyle Armstrong, Caroline Muschet, Anna Artati, Carlo Cusulin, Klaus Christensen, Christoph Patsch, Eshita Sharma, Jerome Nicod, Philip Brownjohn, Victoria Stubbs, Wendy E. Heywood, Paul Gissen, Roberta De Filippis, Katharina Janssen, Peter Reinhardt, Jerzy Adamski, Ines Royaux, Pieter J. Peeters, Georg C. Terstappen, Martin Graf, Frederick J. Livesey, Colin J. Akerman, Kevin Mills, Rory Bowden, George Nicholson, Caleb Webber, M. Zameel Cader, Viktor Lakics
Correction
Biotechnology & Applied Microbiology
Madeline A. Lancaster, Nina S. Corsini, Simone Wolfinger, E. Hilary Gustafson, Alex W. Phillips, Thomas R. Burkard, Tomoki Otani, Frederick J. Livesey, Juergen A. Knoblich
NATURE BIOTECHNOLOGY
(2018)
Article
Multidisciplinary Sciences
Raquel Real, Manuel Peter, Antonio Trabalza, Shabana Khan, Mark A. Smith, Joana Dopp, Samuel J. Barnes, Ayiba Momoh, Alessio Strano, Emanuela Volpi, Graham Knott, Frederick J. Livesey, Vincenzo De Paola
Article
Cell Biology
Christy O. Y. Hung, Frederick J. Livesey
Article
Cell Biology
Francesco Paonessa, Lewis D. Evans, Ravi Solanki, Delphine Larrieu, Selina Wray, John Hardy, Stephen P. Jackson, Frederick J. Livesey
Article
Multidisciplinary Sciences
Teresa G. Krieger, Carla M. Moran, Alberto Frangini, W. Edward Visser, Erik Schoenmakers, Francesco Muntoni, Chris A. Clark, David Gadian, Wui K. Chong, Adam Kuczynski, Mehul Dattani, Greta Lyons, Alexandra Efthymiadou, Faraneh Varga-Khadem, Benjamin D. Simons, Krishna Chatterjee, Frederick J. Livesey
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Neurosciences
Frances St George-Hyslop, Moritz Haneklaus, Toomas Kivisild, Frederick J. Livesey
Summary: Loss-of-function mutations in the CNTNAP2 gene contribute to the pathogenesis of neurodevelopmental disorders by causing complex changes in human cerebral cortex excitatory neuron development, resulting in aberrant neural network formation and function.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemical Research Methods
Sebastian Cachero, Marina Gkantia, Alexander S. Bates, Shahar Frechter, Laura Blackie, Amy McCarthy, Ben Sutcliffe, Alessio Strano, Yoshinori Aso, Gregory S. X. E. Jefferis
Article
Clinical Neurology
Daniel R. Whiten, Philip W. Brownjohn, Steven Moore, Suman De, Alessio Strano, Yukun Zuo, Moritz Haneklaus, David Klenerman, Frederick J. Livesey
BRAIN COMMUNICATIONS
(2020)