The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

Blood flow mechanics in cardiovascular development

(2015) Francesco Boselli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endocardial Notch Signaling in Cardiac Development and Disease

(2015) Guillermo Luxán et al.   CIRCULATION RESEARCH

Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development

(2015) Emilie Heckel et al.   CURRENT BIOLOGY

Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish

(2015) L. A. Samsa et al.   DEVELOPMENT

Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation

(2015) D. Ye et al.   DEVELOPMENT

Myocardium and BMP signaling are required for endocardial differentiation

(2015) S. Palencia-Desai et al.   DEVELOPMENT

The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression

(2015) Zinan Zhou et al.   DEVELOPMENTAL CELL

Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins

(2015) Marc Renz et al.   DEVELOPMENTAL CELL

Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis

(2015) Karen Mendelson et al.   DEVELOPMENTAL DYNAMICS

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

(2015) Brian G. Coon et al.   JOURNAL OF CELL BIOLOGY

Regulation of tissue morphogenesis by endothelial cell-derived signals

(2015) Saravana K. Ramasamy et al.   TRENDS IN CELL BIOLOGY

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

(2015) Nicolas Baeyens et al.   eLife

Notch1 Is Pan-Endothelial at the Onset of Flow and Regulated by Flow

(2015) Espen D. Jahnsen et al.   PLoS One

klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes

(2015) Peter Novodvorsky et al.   PLoS One

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

(2014) Sandeep Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Myocardial contraction and hyaluronic acid mechanotransduction in epithelial-to-mesenchymal transformation of endocardial cells

(2014) Mary Kathryn Sewell-Loftin et al.   BIOMATERIALS

Intracardiac flow dynamics regulate atrioventricular valve morphogenesis

(2014) Stamatia Kalogirou et al.   CARDIOVASCULAR RESEARCH

Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction

(2014) M. Bressan et al.   DEVELOPMENT

High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation

(2014) D. W. Staudt et al.   DEVELOPMENT

Blood Flow and Bmp Signaling Control Endocardial Chamber Morphogenesis

(2014) Ann-Christin Dietrich et al.   DEVELOPMENTAL CELL

S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish

(2014) Hajime Fukui et al.   DEVELOPMENTAL CELL

Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion

(2014) Hui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

High-resolution reconstruction of the beating zebrafish heart

(2014) Michaela Mickoleit et al.   NATURE METHODS

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration

(2014) L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo formation of a distinct coronary vascular population in neonatal heart

(2014) X. Tian et al.   SCIENCE

Advances in understanding the mechanism of zebrafish heart regeneration

(2014) Kazu Kikuchi   Stem Cell Research

Endothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development

(2014) Jacky G. Goetz et al.   Cell Reports

Early patterning and specification of cardiac progenitors in gastrulating mesoderm

(2014) W Patrick Devine et al.   eLife

CCM proteins control endothelial  1 integrin dependent response to shear stress

(2014) Z. Macek Jilkova et al.   Biology Open

Congenital heart malformations induced by hemodynamic altering surgical interventions

(2014) Madeline Midgett et al.   Frontiers in Physiology

Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling

(2013) Oliver Watson et al.   CARDIOVASCULAR RESEARCH

Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner

(2013) Sunny Sun-Kin Chan et al.   Cell Stem Cell

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function

(2013) B. Guner-Ataman et al.   DEVELOPMENT

S1pr2/G 13 signaling controls myocardial migration by regulating endoderm convergence

(2013) D. Ye et al.   DEVELOPMENT

In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration

(2013) W.-Y. Choi et al.   DEVELOPMENT

tal1 regulates the formation of intercellular junctions and the maintenance of identity in the endocardium

(2013) Jennifer A. Schumacher et al.   DEVELOPMENTAL BIOLOGY

In vivo cardiac reprogramming contributes to zebrafish heart regeneration

(2013) Ruilin Zhang et al.   NATURE

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Krüppel-Like Factor 2 Is Required for Normal Mouse Cardiac Development

(2013) Aditi R. Chiplunkar et al.   PLoS One

Hyaluronan: A critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

(2013) Anne Karine Lagendijk et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Nfatc1 directs the endocardial progenitor cells to make heart valve primordium

(2013) Bingruo Wu et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The zebrafish as a model for complex tissue regeneration

(2013) Matthew Gemberling et al.   TRENDS IN GENETICS

Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21

(2013) Toshihiro Banjo et al.   Nature Communications

Haemogenic endocardium contributes to transient definitive haematopoiesis

(2013) Haruko Nakano et al.   Nature Communications

Cilia and coordination of signaling networks during heart development

(2013) Karen Koefoed et al.   Organogenesis

Uncovering the Molecular and Cellular Mechanisms of Heart Development Using the Zebrafish

(2012) David Staudt et al.   Annual Review of Genetics

Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium

(2012) Ben Van Handel et al.   CELL

Importance of Myocyte-Nonmyocyte Interactions in Cardiac Development and Disease

(2012) Ying Tian et al.   CIRCULATION RESEARCH

The Impact of Mechanical Forces in Heart Morphogenesis

(2012) Javier T. Granados-Riveron et al.   Circulation-Cardiovascular Genetics

Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway

(2012) Caitlin Collins et al.   CURRENT BIOLOGY

TGFβ and BMP signaling in cardiac cushion formation: Lessons from mice and chicken

(2012) Boudewijn P.T. Kruithof et al.   DIFFERENTIATION

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

TGF-  Signaling in Endothelial-to-Mesenchymal Transition: The Role of Shear Stress and Primary Cilia

(2012) P. ten Dijke et al.   Science Signaling

The Pathobiology of Arrhythmogenic Cardiomyopathy

(2011) Jeffrey E. Saffitz   Annual Review of Pathology-Mechanisms of Disease

The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development

(2011) Ryan R Poulsen et al.   BMC DEVELOPMENTAL BIOLOGY

Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity

(2011) Steffen Just et al.   CIRCULATION

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

(2011) Wei Wu et al.   CIRCULATION

MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production

(2011) Anne Karine Lagendijk et al.   CIRCULATION RESEARCH

Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition

(2011) Anastasia D. Egorova et al.   CIRCULATION RESEARCH

A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish

(2011) Jason E. Fish et al.   DEVELOPMENT

The heart endocardium is derived from vascular endothelial progenitors

(2011) M. Milgrom-Hoffman et al.   DEVELOPMENT

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development

(2011) K. A. Smith et al.   DEVELOPMENT

The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis

(2011) R. Totong et al.   DEVELOPMENT

Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function

(2011) S. Palencia-Desai et al.   DEVELOPMENT

Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo

(2011) X. Lou et al.   DEVELOPMENT

Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish

(2011) Savo Lazic et al.   DEVELOPMENTAL BIOLOGY

Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart

(2011) Yi-Fan Lin et al.   DEVELOPMENTAL BIOLOGY

Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish

(2011) Kuan Shen Wong et al.   DEVELOPMENTAL BIOLOGY

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

(2011) Bilge Yoruk et al.   DEVELOPMENTAL BIOLOGY

Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration

(2011) Kazu Kikuchi et al.   DEVELOPMENTAL CELL

Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells

(2011) Anastasia D. Egorova et al.   DEVELOPMENTAL DYNAMICS

Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish

(2011) Courtney Peshkovsky et al.   DEVELOPMENTAL DYNAMICS

Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity?

(2011) E. Oechslin et al.   EUROPEAN HEART JOURNAL

Latent TGF-β binding protein 3 identifies a second heart field in zebrafish

(2011) Yong Zhou et al.   NATURE

Tbx20, Smads, and the Atrioventricular Canal

(2011) Reena Singh et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Integrin Cytoplasmic Domain–Associated Protein-1 Attenuates Sprouting Angiogenesis

(2010) René Brütsch et al.   CIRCULATION RESEARCH

A dual role for ErbB2 signaling in cardiac trabeculation

(2010) J. Liu et al.   DEVELOPMENT

Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function

(2010) Z. V. Garavito-Aguilar et al.   DEVELOPMENT

The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis

(2010) D. C. Deacon et al.   DEVELOPMENT

Hemodynamic patterning of the avian atrioventricular valve

(2010) Huseyin C. Yalcin et al.   DEVELOPMENTAL DYNAMICS

CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

(2010) Xiangjian Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143

(2010) Kota Y. Miyasaka et al.   MECHANISMS OF DEVELOPMENT

The Effects of Hemodynamic Force on Embryonic Development

(2010) JAMES C. CULVER et al.   MICROCIRCULATION

MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis

(2010) Stefania Nicoli et al.   NATURE

Development of the Endocardium

(2010) Ian S. Harris et al.   PEDIATRIC CARDIOLOGY

Effect of Vascular Cadherin Knockdown on Zebrafish Vasculature during Development

(2010) Ian C. Mitchell et al.   PLoS One

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

(2010) Joycelyn Wüstehube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

PECAM-1 Is Necessary for Flow-Induced Vascular Remodeling

(2009) Zhongming Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heart Valve Development

(2009) Michelle D. Combs et al.   CIRCULATION RESEARCH

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

(2009) E. de Pater et al.   DEVELOPMENT

Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors

(2009) Andrew M. Misfeldt et al.   DEVELOPMENTAL BIOLOGY

Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

(2009) G. Boulday et al.   Disease Models & Mechanisms

Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway

(2009) Benjamin Kleaveland et al.   NATURE MEDICINE

Transcriptional Regulation of Heart Valve Progenitor Cells

(2009) Santanu Chakraborty et al.   PEDIATRIC CARDIOLOGY

Nkx2–5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo

(2009) Anwarul Ferdous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shaping Morphogen Gradients by Proteoglycans

(2009) D. Yan et al.   Cold Spring Harbor Perspectives in Biology

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart

(2009) Julien Vermot et al.   PLOS BIOLOGY

The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish

(2008) Nick Osborne et al.   CURRENT BIOLOGY

High-speed imaging of developing heart valves reveals interplay of morphogenesis and function

(2008) P. J. Scherz et al.   DEVELOPMENT

Origin and fate of cardiac mesenchyme

(2008) Brian S. Snarr et al.   DEVELOPMENTAL DYNAMICS

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish

(2008) Benjamin M. Hogan et al.   HUMAN MOLECULAR GENETICS

Cell lineage in mammalian craniofacial mesenchyme

(2008) Toshiyuki Yoshida et al.   MECHANISMS OF DEVELOPMENT

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE

The Endothelial Glycocalyx: A Mechano-Sensor and -Transducer

(2008) J. M. Tarbell et al.   Science Signaling