Immunomodulatory roles of microbiota-derived short-chain fatty acids in bacterial infections

Bacterial biofilm in colorectal cancer: What is the real mechanism of action?

(2020) Rasoul Mirzaei et al.   MICROBIAL PATHOGENESIS

Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism

(2020) Rasoul Mirzaei et al.   IUBMB LIFE

Free Fatty Acid Receptors 2 and 3 as Microbial Metabolite Sensors to Shape Host Health: Pharmacophysiological View

(2020) Sidharth P. Mishra et al.   Biomedicines

Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice

(2019) Xiaoli Tian et al.   Frontiers in Microbiology

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

(2019) José Luís Fachi et al.   Cell Reports

Propionate Ameliorates Staphylococcus aureus Skin Infection by Attenuating Bacterial Growth

(2019) Soyoung Jeong et al.   Frontiers in Microbiology

Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine

(2019) Jin Sun You et al.   Microbiome

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2

(2019) José Luís Fachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

(2018) P. A. Gill et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease

(2018) Holm H. Uhlig et al.   Annual Review of Immunology

Butyricicoccus porcorum sp. nov., a butyrate-producing bacterium from swine intestinal tract

(2018) Julian Trachsel et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Microbiome, Immunomodulation, and the Neuronal System

(2018) Eric Marietta et al.   Neurotherapeutics

The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Stimulated Endothelial Cells via Activation of GPR41/43 and Inhibition of HDACs

(2018) Meng Li et al.   Frontiers in Pharmacology

Microbiota-accessible carbohydrates suppress Clostridium difficile infection in a murine model

(2018) Andrew J. Hryckowian et al.   Nature Microbiology

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

(2018) Guangxin Chen et al.   EBioMedicine

Metabolome analysis for investigating host-gut microbiota interactions

(2018) Michael X. Chen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens

(2018) Zhendong Li et al.   Frontiers in Cellular and Infection Microbiology

Role of Short Chain Fatty Acids in Controlling Tregs and Immunopathology During Mucosal Infection

(2018) Natarajan Bhaskaran et al.   Frontiers in Microbiology

Zinc-Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration

(2018) Wei Liu et al.   Advanced Science

Gut microbiome contributes to impairment of immunity in pulmonary tuberculosis patients by alteration of butyrate and propionate producers

(2017) Abhijit Maji et al.   ENVIRONMENTAL MICROBIOLOGY

The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System

(2017) Agatha Schwarz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Butyrate Supplementation at High Concentrations Alters Enteric Bacterial Communities and Reduces Intestinal Inflammation in Mice Infected with Citrobacter rodentium

(2017) Janelle A. Jiminez et al.   mSphere

The Human Microbiota in Health and Disease

(2017) Baohong Wang et al.   Engineering

Mechanisms of Pediatric Inflammatory Bowel Disease

(2016) Joanna M. Peloquin et al.   Annual Review of Immunology

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

(2016) Fabian Rivera-Chávez et al.   Cell Host & Microbe

Commensal-Specific CD4+ Cells From Patients With Crohn’s Disease Have a T-Helper 17 Inflammatory Profile

(2016) Elisabeth Calderón-Gómez et al.   GASTROENTEROLOGY

Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors

(2016) Jennifer L. Pluznick   KIDNEY INTERNATIONAL

Interactions between the microbiota and pathogenic bacteria in the gut

(2016) Andreas J. Bäumler et al.   NATURE

Epithelial glycosylation in gut homeostasis and inflammation

(2016) Yoshiyuki Goto et al.   NATURE IMMUNOLOGY

Short Chain Fatty Acids (SCFA) Reprogram Gene Expression in Human Malignant Epithelial and Lymphoid Cells

(2016) Lidiia Astakhova et al.   PLoS One

Functional Redundancy-Induced Stability of Gut Microbiota Subjected to Disturbance

(2016) Andrés Moya et al.   TRENDS IN MICROBIOLOGY

Effect of Bifidobacterium upon Clostridium difficile Growth and Toxicity When Co-cultured in Different Prebiotic Substrates

(2016) L. Valdés-Varela et al.   Frontiers in Microbiology

Diabetes Mellitus and Increased Tuberculosis Susceptibility: The Role of Short-Chain Fatty Acids

(2016) Ekta Lachmandas et al.   Journal of Diabetes Research

Review article: insights into colonic protein fermentation, its modulation and potential health implications

(2015) C. K. Yao et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing ofMycobacterium tuberculosisin human macrophages

(2015) Rokeya Sultana Rekha et al.   Autophagy

Frenemies: Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions

(2015) Elizabeth A. Cameron et al.   Cell Host & Microbe

Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth

(2015) Peyman Ghorbani et al.   EUROPEAN RESPIRATORY JOURNAL

Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial

(2015) Craig H Moskowitz et al.   LANCET

A comprehensive repertoire of prokaryotic species identified in human beings

(2015) Perrine Hugon et al.   LANCET INFECTIOUS DISEASES

Erratum: HDAC inhibitors still need a home run, despite recent approval

(2015) Malini Guha   NATURE REVIEWS DRUG DISCOVERY

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

(2015) Angélica T. Vieira et al.   Arthritis & Rheumatology

From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology

(2014) Niranjana Natarajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

(2014) Casey M. Theriot et al.   Nature Communications

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

(2014) Richard Brad Jones et al.   PLoS Pathogens

Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells

(2014) Mariagrazia Valentini et al.   Journal of Immunology Research

Contributions of Colonic Short-Chain Fatty Acid Receptors in Energy Homeostasis

(2014) Atsukazu Kuwahara   Frontiers in Endocrinology

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

(2013) Laura Wrzosek et al.   BMC BIOLOGY

Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection

(2013) Mark J. Koenigsknecht et al.   CURRENT OPINION IN GASTROENTEROLOGY

Resident commensals shaping immunity

(2013) Deniz Erturk-Hasdemir et al.   CURRENT OPINION IN IMMUNOLOGY

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Intestinal Dysbiosis and Depletion of Butyrogenic Bacteria in Clostridium difficile Infection and Nosocomial Diarrhea

(2013) V. C. Antharam et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells

(2013) Quan Liu et al.   Journal of Inflammation-London

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor  

(2013) S. Alex et al.   MOLECULAR AND CELLULAR BIOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Control of pathogens and pathobionts by the gut microbiota

(2013) Nobuhiko Kamada et al.   NATURE IMMUNOLOGY

Epithelial Cell Proliferation Arrest Induced by Lactate and Acetate from Lactobacillus casei and Bifidobacterium breve

(2013) Takahiro Matsuki et al.   PLoS One

Dietary choice affects Shiga toxin-producingEscherichia coli(STEC) O157:H7 colonization and disease

(2013) Steven D. Zumbrun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Regulatory T Cells and Immune Tolerance in the Intestine

(2013) O. J. Harrison et al.   Cold Spring Harbor Perspectives in Biology

Balancing osteoblast functions and bacterial adhesion on functionalized titanium surfaces

(2012) Koon Gee Neoh et al.   BIOMATERIALS

The microbiome as a human organ

(2012) F. Baquero et al.   CLINICAL MICROBIOLOGY AND INFECTION

Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non–Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy

(2012) Samir E. Witta et al.   JOURNAL OF CLINICAL ONCOLOGY

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases: Figure 1

(2011) Alexander J.P. Edwards et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses

(2011) Dan R. Littman et al.   Cell Host & Microbe

Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity

(2011) Caspar Ohnmacht et al.   CELLULAR MICROBIOLOGY

Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells

(2011) Ulf H Beier et al.   CURRENT OPINION IN IMMUNOLOGY

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial

(2011) Anas Younes et al.   LANCET ONCOLOGY

Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia hasin vitrobut limited clinical activity

(2011) Steven Lane et al.   LEUKEMIA & LYMPHOMA

The role of IL-10 in immune regulation during M. tuberculosis infection

(2011) P S Redford et al.   Mucosal Immunology

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

(2011) Roberto Berni Canani   WORLD JOURNAL OF GASTROENTEROLOGY

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Biology of Clostridium difficile: Implications for Epidemiology and Diagnosis

(2010) Carroll Karen C. et al.   Annual Review of Microbiology

From the gut to the peripheral tissues: the multiple effects of butyrate

(2010) P. Guilloteau et al.   NUTRITION RESEARCH REVIEWS

Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation

(2009) Jérôme Lugrin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation

(2008) Stephen W. Ragsdale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Butyrate protects Caco-2 cells from Campylobacter jejuni invasion and translocation

(2008) Kim Van Deun et al.   BRITISH JOURNAL OF NUTRITION

Innate immune recognition of the indigenous microbial flora

(2008) S Rakoff-Nahoum et al.   Mucosal Immunology

Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

(2008) Makoto Usami et al.   NUTRITION RESEARCH