The gut microbiota, bacterial metabolites and colorectal cancer

Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells

(2014) Antoaneta Belcheva et al.   CELL

Microbes, Microbiota, and Colon Cancer

(2014) Cynthia L. Sears et al.   Cell Host & Microbe

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

(2014) Nicole Reichardt et al.   ISME Journal

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans

(2013) Junhai Ou et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma

(2013) Hui-Min Chen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid

(2013) Ferenc Májer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

(2013) Aleksandar D. Kostic et al.   Cell Host & Microbe

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Toxicity of Polyamines and Their Metabolic Products

(2013) Anthony E. Pegg   CHEMICAL RESEARCH IN TOXICOLOGY

Colonic bacterial metabolites and human health

(2013) Wendy R Russell et al.   CURRENT OPINION IN MICROBIOLOGY

Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

(2013) Vadivel Ganapathy et al.   CURRENT OPINION IN PHARMACOLOGY

Polyamines: Emerging players in bacteria–host interactions

(2013) Maria Letizia Di Martino et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice

(2013) A Marcobal et al.   ISME Journal

Impact of Polyphenols and Polyphenol-Rich Dietary Sources on Gut Microbiota Composition

(2013) Usune Etxeberria et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Contribution of the 7β-hydroxysteroid dehydrogenase fromRuminococcus gnavusN53 to ursodeoxycholic acid formation in the human colon

(2013) Ja-Young Lee et al.   JOURNAL OF LIPID RESEARCH

Benefits of polyphenols on gut microbiota and implications in human health

(2013) Fernando Cardona et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein

(2013) Wendy R. Russell et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

(2013) Thomas Secher et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

The Gut Microbiome Modulates Colon Tumorigenesis

(2013) J. P. Zackular et al.   mBio

Co-occurrence of anaerobic bacteria in colorectal carcinomas

(2013) René L Warren et al.   Microbiome

A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate

(2012) Kim Y. C. Fung et al.   BRITISH JOURNAL OF NUTRITION

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

(2012) Hachung Chung et al.   CELL

Phylogenetic distribution of genes encoding β-glucuronidase activity in human colonic bacteria and the impact of diet on faecal glycosidase activities

(2012) Freda M. McIntosh et al.   ENVIRONMENTAL MICROBIOLOGY

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

(2012) Nina Sanapareddy et al.   ISME Journal

The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic–anoxic interphases

(2012) M Tanweer Khan et al.   ISME Journal

Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis

(2012) Matthew D. Neal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IBD—what role do Proteobacteria play?

(2012) Indrani Mukhopadhya et al.   Nature Reviews Gastroenterology & Hepatology

Contributions of the microbial hydrogen economy to colonic homeostasis

(2012) Franck Carbonero et al.   Nature Reviews Gastroenterology & Hepatology

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

(2012) Harold Tjalsma et al.   NATURE REVIEWS MICROBIOLOGY

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Butyrate Produced by Commensal Bacteria Potentiates Phorbol Esters Induced AP-1 Response in Human Intestinal Epithelial Cells

(2012) Malgorzata Nepelska et al.   PLoS One

Modulation of Protein Fermentation Does Not Affect Fecal Water Toxicity: A Randomized Cross-Over Study in Healthy Subjects

(2012) Karen Windey et al.   PLoS One

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Intestinal redox biology and oxidative stress

(2012) Magdalena L. Circu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Bile acids in the colon, from healthy to cytotoxic molecules

(2012) Juan I. Barrasa et al.   TOXICOLOGY IN VITRO

N-nitroso compounds and cancer incidence: the European Prospective Investigation into Cancer and Nutrition (EPIC)–Norfolk Study

(2011) Yet Hua Loh et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health

(2011) Wendy R Russell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

(2011) A. D. Kostic et al.   GENOME RESEARCH

Colitis-associated cancer: the dark side of inflammatory bowel disease

(2011) S. Danese et al.   GUT

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Abundance and diversity of mucosa-associated hydrogenotrophic microbes in the healthy human colon

(2011) Gerardo M Nava et al.   ISME Journal

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

Alternative Spermidine Biosynthetic Route Is Critical for Growth ofCampylobacter jejuniand Is the Dominant Polyamine Pathway in Human Gut Microbiota

(2011) Colin C. Hanfrey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and characterization of two bile acid coenzyme A transferases fromClostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium

(2011) Jason M. Ridlon et al.   JOURNAL OF LIPID RESEARCH

Fecal Butyrate Levels Vary Widely among Individuals but Are Usually Increased by a Diet High in Resistant Starch

(2011) Alexandra L. McOrist et al.   JOURNAL OF NUTRITION

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

(2011) John Burn et al.   LANCET

Relevance of protein fermentation to gut health

(2011) Karen Windey et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Association Between Low Colonic Short-Chain Fatty Acids and High Bile Acids in High Colon Cancer Risk Populations

(2011) Junhai Ou et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The Inflammatory Microenvironment in Colorectal Neoplasia

(2011) Mairi H. McLean et al.   PLoS One

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

(2011) A. C. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant secondary metabolites and gut health: the case for phenolic acids

(2011) Wendy Russell et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Genomic Insights into Syntrophy: The Paradigm for Anaerobic Metabolic Cooperation

(2010) Jessica R. Sieber et al.   Annual Review of Microbiology

Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction

(2010) A. J. Wilson et al.   CANCER RESEARCH

Dietary constituents of broccoli and other cruciferous vegetables: Implications for prevention and therapy of cancer

(2010) Ingrid Herr et al.   CANCER TREATMENT REVIEWS

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Expression of the antimicrobial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice

(2010) Yuhei Inaba et al.   INFLAMMATORY BOWEL DISEASES

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

(2010) Alan W Walker et al.   ISME Journal

Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation

(2010) Michelle L. Sleeth et al.   NUTRITION RESEARCH REVIEWS

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Enterotoxigenic Bacteroides fragilis: a Rogue among Symbiotes

(2009) C. L. Sears   CLINICAL MICROBIOLOGY REVIEWS

Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene

(2009) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Lactate has the potential to promote hydrogen sulphide formation in the human colon

(2009) Perrine Marquet et al.   FEMS MICROBIOLOGY LETTERS

Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

(2009) Petra Louis et al.   FEMS MICROBIOLOGY LETTERS

Exploring the link between microorganisms and oral cancer: A systematic review of the literature

(2009) Samuel J. Hooper et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models

(2009) Mar Larrosa et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Bile acids as endogenous etiologic agents in gastrointestinal cancer

(2009) Harris Bernstein et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of high-amylose maize starch and butyrylated high-amylose maize starch on azoxymethane-induced intestinal cancer in rats

(2008) J. M. Clarke et al.   CARCINOGENESIS

Lactaturia and Loss of Sodium-dependent Lactate Uptake in the Colon of SLC5A8-deficient Mice

(2008) Henning Frank et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

(2008) Sonia Ramos   MOLECULAR NUTRITION & FOOD RESEARCH

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation

(2008) Caitlin O'Mahony et al.   PLoS Pathogens