From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: Study in juvenile diabetic rat

(2014) S. Khan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Short-Chain Fatty Acids from Periodontal Pathogens Suppress Histone Deacetylases, EZH2, and SUV39H1 To Promote Kaposi's Sarcoma-Associated Herpesvirus Replication

(2014) X. Yu et al.   JOURNAL OF VIROLOGY

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Chemosensory Functions for Pulmonary Neuroendocrine Cells

(2013) Xiaoling Gu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival

(2013) S. Elangovan et al.   CANCER RESEARCH

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Epithelia of the ovine and bovine forestomach express basolateral maxi-anion channels permeable to the anions of short-chain fatty acids

(2013) Maria I. Georgi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Urea in Intestinal Barrier Dysfunction and Disruption of Epithelial Tight Junction in Chronic Kidney Disease

(2012) Nosratola D. Vaziri et al.   AMERICAN JOURNAL OF NEPHROLOGY

A novel nutrient sensing mechanism underlies substrate-induced regulation of monocarboxylate transporter-1

(2012) Alip Borthakur et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver

(2012) L B Bindels et al.   BRITISH JOURNAL OF CANCER

CKD impairs barrier function and alters microbial flora of the intestine

(2012) Nosratola D. Vaziri   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Butyrate-induced GPR41 Activation Inhibits Histone Acetylation and Cell Growth

(2012) Jin Wu et al.   Journal of Genetics and Genomics

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Immune Disorders and Its Correlation with Gut Microbiome

(2012) Ji-Sun Hwang et al.   Immune Network

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans

(2011) Reiner Jumpertz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Inhibitors of Histone Deacetylases

(2011) Kelly Huber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Butyrate-Induced Apoptosis in HCT116 Colorectal Cancer Cells Includes Induction of a Cell Stress Response

(2011) Kim Y. C. Fung et al.   JOURNAL OF PROTEOME RESEARCH

Expression and Distribution of the Sweet Taste Receptor Isoforms T1R2 and T1R3 in Human and Rat Bladders

(2011) Ruth A. Elliott et al.   JOURNAL OF UROLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

The intestinal microbiota and chronic disorders of the gut

(2011) Andrew W. DuPont et al.   Nature Reviews Gastroenterology & Hepatology

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

(2010) Claire Barbier de La Serre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea

(2010) Henry J. Binder   Annual Review of Physiology

Histone acetylation: Where to go and how to get there

(2010) Vicki E. MacDonald et al.   Epigenetics

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases

(2010) Nagendra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

(2010) Deepak A Deshpande et al.   NATURE MEDICINE

Expression of short-chain fatty acid receptor GPR41 in the human colon

(2009) Hideaki Tazoe et al.   BIOMEDICAL RESEARCH-TOKYO

MOR23 Promotes Muscle Regeneration and Regulates Cell Adhesion and Migration

(2009) Christine A. Griffin et al.   DEVELOPMENTAL CELL

Sequence Polymorphisms Provide a Common Consensus Sequence for GPR41 and GPR42

(2009) Chen W. Liaw et al.   DNA AND CELL BIOLOGY

Colonic Gene Expression in Conventional and Germ-Free Mice with a Focus on the Butyrate Receptor GPR109A and the Butyrate Transporter SLC5A8

(2009) Gail A. Cresci et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Proteomic Analysis of Butyrate Effects and Loss of Butyrate Sensitivity in HT29 Colorectal Cancer Cells

(2009) Kim Y. C. Fung et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways

(2009) Michiko Aoyama et al.   NUTRITION

Functional expression of the olfactory signaling system in the kidney

(2009) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3

(2008) Muthusamy Thangaraju et al.   BIOCHEMICAL JOURNAL

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Lactaturia and Loss of Sodium-dependent Lactate Uptake in the Colon of SLC5A8-deficient Mice

(2008) Henning Frank et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate

(2008) Rafiqul Islam et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-chain fatty acid signaling pathways in bovine mammary epithelial cells

(2008) Tomo Yonezawa et al.   REGULATORY PEPTIDES