The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Stimulated Endothelial Cells via Activation of GPR41/43 and Inhibition of HDACs

Time and Concentration Dependent Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Induced Endothelial Activation

(2018) Meng Li et al.   Frontiers in Pharmacology

Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects

(2016) Florence Namour et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

(2016) Niek GJ Leus et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Activation of liver X receptor attenuates lysophosphatidylcholine-induced IL-8 expression in endothelial cellsviathe NF-κB pathway and SUMOylation

(2016) Xukun Bi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

Secreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor

(2016) Myoung Soo Park et al.   Scientific Reports

Histone deacetylases and atherosclerosis

(2015) Xia-xia Zheng et al.   ATHEROSCLEROSIS

Sargaquinoic Acid Inhibits TNF-α-Induced NF-κB Signaling, Thereby Contributing to Decreased Monocyte Adhesion to Human Umbilical Vein Endothelial Cells (HUVECs)

(2015) Wi-Gyeong Gwon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Impaired Vitamin D Signaling in Endothelial Cell Leads to an Enhanced Leukocyte-Endothelium Interplay: Implications for Atherosclerosis Development

(2015) Milica Bozic et al.   PLoS One

A Healthy Diet Is Associated with Less Endothelial Dysfunction and Less Low-Grade Inflammation over a 7-Year Period in Adults at Risk of Cardiovascular Disease

(2015) Bas CT van Bussel et al.   JOURNAL OF NUTRITION

Inflammation and Atherosclerosis

(2014) Joshua Hartman et al.   Cardiology in Review

Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes

(2014) Alessandra Puddu et al.   MEDIATORS OF INFLAMMATION

Histone deacetylases as targets for treatment of multiple diseases

(2013) Jinhua Tang et al.   CLINICAL SCIENCE

Soy protein inhibits inflammation-induced VCAM-1 and inflammatory cytokine induction by inhibiting the NF-κB and AKT signaling pathway in apolipoprotein E–deficient mice

(2013) Ramona L. Burris et al.   EUROPEAN JOURNAL OF NUTRITION

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry

(2013) Ruth E. Westenbroek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

GPR43/FFA2: physiopathological relevance and therapeutic prospects

(2013) Laure B. Bindels et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs

(2013) Melissa D. Cantley et al.   INFLAMMOPHARMACOLOGY

Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium

(2012) Beamon Agarwal et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Role of histone deacetylases in transcription factor regulation and cell cycle modulation in endothelial cells in response to disturbed flow

(2012) D.-Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

(2010) R. P. Hebbel et al.   BLOOD

Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

(2010) Kees Meijer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Apical TLR ligation of intestinal epithelial cells drives a Th1-polarized regulatory or inflammatory type effector response in vitro

(2010) Sander de Kivit et al.   IMMUNOBIOLOGY

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease

(2009) D. Pons et al.   EUROPEAN HEART JOURNAL

G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation

(2009) C. Sina et al.   JOURNAL OF IMMUNOLOGY

Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways

(2009) Michiko Aoyama et al.   NUTRITION

PROTECTIVE EFFECT OF SUBEROYLANILIDE HYDROXAMIC ACID AGAINST LPS-INDUCED SEPTIC SHOCK IN RODENTS

(2009) Yongqing Li et al.   SHOCK

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY