Article
Immunology
Kongwei Guo, Yanxing Shang, Zhao Wang, Yu Li, Jinliang Chen, Baofeng Zhu, Dongmei Zhang, Jianrong Chen
Summary: BRG1 plays a key role in apoptosis and oxidative damage, but its role in the pathophysiology of ischemic stroke is unclear. We found that BRG1 expression was increased during cerebral ischemia and reperfusion, particularly in activated microglia. Modulating BRG1 expression levels significantly affected microglial activation and the expression of antioxidant and pro-oxidant proteins after ischemic stroke. Our findings suggest that BRG1 protects against brain ischemia/reperfusion injury by reducing oxidative damage through the KEAP1-NRF2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Meijuan Yin, Zhenyi Liu, Jing Wang, Weijuan Gao
Summary: The aim of this study was to investigate the molecular mechanism of Buyang Huanwu Decoction (BYHWD) in attenuating cerebral ischemia-reperfusion (I/R) oxidative damage by activating the PKC epsilon/Nrf2/HO-1 pathway. The results showed that BYHWD improved neural function, reduced neuronal damage, inhibited ROS production, decreased MDA and 8-OHdG levels, increased SOD and GSH-PX activity, and restored mitochondrial membrane potential. BYHWD activated the expression of Nrf2 and PKC epsilon, promoted Nrf2 translocation, and enhanced HO-1 expression. Therefore, BYHWD attenuates oxidative damage and reduces brain I/R injury by activating the PKC epsilon/Nrf2/HO-1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Wenya Bai, Siying Huo, Guilin Zhou, Junjie Li, Yuan Yang, Jianlin Shao
Summary: This study investigated the potential of Biliverdin to alleviate cerebral ischemia reperfusion injury (CIRI) by inhibiting pyroptosis. Biliverdin was found to significantly alleviate CIRI both in vivo and in vitro by activating the Nrf2/A20/eEF1A2 axis, which in turn inhibited the NF-KB pathway. The findings of this study provide insights into novel therapeutic targets for the treatment of CIRI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Xia Liu, Miao Ren, Anqi Zhang, Changshun Huang, Junlu Wang
Summary: This study investigated the potential role of ciprofol in cerebral ischemia-reperfusion injury (CIRI) and found that it can alleviate neurological deficits and reduce damage through the Nrf2-xCT-GPX4 signaling pathway.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Cardiac & Cardiovascular Systems
Ibolya Rutkai, Ivan Merdzo, Sanjay Wunnava, Catherine McNulty, Partha K. Chandra, Prasad Katakam, David W. Busija
Summary: Differences in mitochondrial characteristics, including morphology, respiration, and calcium sparks activity, between male and female rats may contribute to sex differences in protective and repair mechanisms in response to transient ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Plant Sciences
Qingwen Hu, Tianrui Zuo, Ling Deng, Sha Chen, Shengwei Liu, JingDong Liu, Xuan Wang, Xiaomei Fan, Zhi Dong
Summary: This study suggests that ferroptosis plays a critical role in the pathogenesis of acute ischemic stroke. β-Caryophyllene (BCP) has neuroprotective effects by regulating ferroptosis and activating the NRF2/HO-1 signaling pathway to improve cerebral ischemia injury.
Article
Pharmacology & Pharmacy
Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Tao
Summary: Stroke is a major cause of death, with oxidative stress playing a key role. Celastrol has strong antioxidant properties, but its effect on oxidative reactions in cerebral ischemic-reperfusion injury (CIRI) is unclear. This study aimed to investigate the impact of celastrol on oxidative damage during CIRI and the underlying mechanisms. The findings revealed that celastrol reduced oxidative injury in CIRI by upregulating Nrf2. Celastrol directly bound to Nedd4, releasing Nrf2 in astrocytes, thus inhibiting Nrf2 degradation and reducing astrocytic ROS production. Celastrol also rescued neurons from damage and apoptosis by inhibiting oxidative stress and astrocyte activation.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Lingfeng Wang, Ying Guo, Jiayi Ye, Zeyue Pan, Peihao Hu, Xiaoming Zhong, Fengmei Qiu, Danni Zhang, Zhen Huang
Summary: The study demonstrated that piceatannol has a protective effect against CIRI by increasing cell viability, reducing oxidative stress, alleviating neurological deficits and cerebral infarction damage. This protective effect is achieved through enhancing antioxidant enzyme activities and modulating gene expression related to oxidative stress response.
NEUROCHEMICAL RESEARCH
(2021)
Article
Cell Biology
Guoxing You, Linbo Zheng, Yuanyuan Zhang, Yuting Zhang, Yupeng Wang, Wenjie Guo, Hao Liu, Philipovich Tatiana, Kulchitsky Vladimir, Jie Zan
Summary: This study investigated the protective mechanism of TANG against cerebral ischemia/reperfusion (I/R) injury. The results showed that TANG could alleviate brain injury and inhibit neuronal pyroptosis induced by I/R both in vivo and in vitro. Furthermore, TANG inhibited the activation of neuronal AIM2 inflammasome via regulating NRF2. Therefore, TANG may be a potential therapeutic agent for cerebral I/R injury.
Article
Biochemistry & Molecular Biology
Lei Chen, Jie Huang, Zi-Meng Yao, Xiao-Rong Sun, Xu-Hui Tong, Miao Hu, Ying Zhang, Shu-Ying Dong
Summary: In this study, it was found that procyanidins (PCs), as organic antioxidants, can suppress oxidative stress, exhibit anti-apoptotic properties, and chelate metal ions. Pre-administration of PCs for 7 days enhanced nerve function and reduced cerebellar infarct volume in a mouse model of cerebral ischemia/reperfusion injury (CIRI). Furthermore, PCs were able to promote mitochondrial ferroptosis and alter the expression of proteins associated with ferroptosis, ultimately inhibiting this form of cell death.
Article
Medicine, Research & Experimental
Xiaoyang Lan, Yumin Xu
Summary: Lidocaine, a local anesthetic, has been shown to exhibit neuroprotective effects against neuronal damage induced by OGD/R through the activation of the Wnt/beta-catenin signaling pathway, leading to reduced apoptosis in cortical neurons.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ilaria Dettori, Lisa Gaviano, Filippo Ugolini, Daniele Lana, Irene Bulli, Giada Magni, Francesca Rossi, Maria Grazia Giovannini, Felicita Pedata
Summary: This study demonstrates that stimulation of A(2B) receptors can attenuate neuroinflammation that develops after ischemia, indicating that A(2B) receptors may be a new interesting pharmacological target for protecting against degeneration following brain ischemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tao Huang, Junping Yin, Song'e Ren, Xuling Zhang
Summary: The role of KLF4 in CI/R injury and the Nrf2/Trx1 pathway as a downstream pathway of KLF4 in protecting blood-brain barrier after CI/R were investigated. In vivo and in vitro models were established to evaluate the protective role of KLF4 on CI/R and the effect on blood-brain barrier permeability. The results showed that KLF4 exerted a neuroprotective effect through the upregulation of the Nrf2/Trx1 pathway.
Article
Plant Sciences
Yan She, Le Shao, Keyan Jiao, Ruiting Sun, Ting Lang, Hongping Long, Yinghong Tang, Wei Zhang, Changsong Ding, Changqing Deng
Summary: This study demonstrated for the first time that glycosides inhibited neuronal pyroptosis by regulating the Nrf2-mediated antioxidant stress pathway, thereby exerting brain protection during cerebral ischemia-reperfusion. This study improved understanding of the pharmacodynamics and mechanism of BYHWD and provided a Traditional Chinese Medicine (TCM) treatment strategy for cerebral ischemia-reperfusion.
Article
Plant Sciences
Ying Guo, Mingjiang Mao, Qiuying Li, Xiahui Yu, Liping Zhou
Summary: The combination of Ginkgo flavonoids and ginkgolides showed a significant protective effect in reducing cerebral ischaemia-reperfusion injury. This effect may be achieved by activating the PI3K/Akt/Nrf2 signaling pathway and promoting multicomponent interactions in vivo.
