Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity

Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin

(2021) Shujuan Zhou et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Prospective Protective Effect of Ellagic Acid as a SIRT1 Activator in Iron Oxide Nanoparticle-Induced Renal Damage in Rats

(2020) Eman Taha Mohammed et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation

(2020) Sung Min Nam et al.   Biomolecules

Allicin Alleviates Lead-Induced Bone Loss by Preventing Oxidative Stress and Osteoclastogenesis Via SIRT1/FOXO1 Pathway in Mice

(2020) Dong Li et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity

(2020) Keum-Young So et al.   CELL BIOLOGY AND TOXICOLOGY

Arsenic Exposure and Compromised Protein Quality Control

(2020) Lok Ming Tam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels

(2020) Dandan Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sirtuin 3 is required for the protective effect of Resveratrol on Manganese‐induced disruption of mitochondrial biogenesis in primary cultured neurons

(2020) Qian Sun et al.   JOURNAL OF NEUROCHEMISTRY

The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

(2020) Jing Lu et al.   Frontiers in Pharmacology

Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1

(2020) Attalla Farag El-kott et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Manganese-induced Mitochondrial Dysfunction Is Not Detectable at Exposures Below the Acute Cytotoxic Threshold in Neuronal Cell Types

(2020) Emily B Warren et al.   TOXICOLOGICAL SCIENCES

miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload

(2020) Li Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Manganese-induced neurodegenerative diseases and possible therapeutic approaches

(2020) Airton C. Martins et al.   Expert Review of Neurotherapeutics

Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis

(2020) Rili Hao et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant Modulation of mTOR and Sirtuin Pathways in Age-Related Neurodegenerative Diseases

(2020) Asmaa Abdullah et al.   MOLECULAR NEUROBIOLOGY

Arsenic suppresses GDF1 expression via ROS-dependent downregulation of specificity protein 1

(2020) Xiaobo Gao et al.   ENVIRONMENTAL POLLUTION

The Roles of Mitochondrial SIRT4 in Cellular Metabolism

(2019) Zheying Min et al.   Frontiers in Endocrinology

Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function

(2019) Munehiro Kitada et al.   Frontiers in Endocrinology

Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells

(2019) Marco Clementino et al.   TOXICOLOGICAL SCIENCES

Overexpression of miR-138-5p suppresses MnCl2 -induced autophagy by targeting SIRT1 in SH-SY5Y cells

(2019) Junxiang Ma et al.   ENVIRONMENTAL TOXICOLOGY

Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells

(2019) Xin Chou et al.   ARCHIVES OF TOXICOLOGY

Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis

(2019) Surbhi Dogra et al.   Nanomedicine-Nanotechnology Biology and Medicine

Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles

(2019) Doumandji Zahra et al.   CELL BIOLOGY AND TOXICOLOGY

The role of different SIRT1-mediated signaling pathways in toxic injury

(2019) Zhihua Ren et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Metformin in contrast to berberine reversed arsenic‐induced oxidative stress in mitochondria from rat pancreas probably via Sirt3‐dependent pathway

(2019) Mansoureh Javadipour et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Resveratrol protects against cadmium chloride‐induced hippocampal neurotoxicity by inhibiting ER stress and GAAD 153 and activating sirtuin 1/AMPK/Akt

(2019) Ali A. Shati   ENVIRONMENTAL TOXICOLOGY

Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma

(2019) Ke Ma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats

(2019) Yue Zhao et al.   TOXICOLOGY LETTERS

Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity

(2019) Siwen Li et al.   CHEMOSPHERE

Exploring the kidney hazard of exposure to mercuric chloride in mice:Disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis

(2019) Siyu Li et al.   CHEMOSPHERE

Inhibition of Mitochondrial Fatty Acid Oxidation Contributes to Development of Nonalcoholic Fatty Liver Disease Induced by Environmental Cadmium Exposure

(2019) Xiwei He et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

(2019) Zhou Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

The Roles of Sirtuin Family Proteins in Cancer Progression

(2019) Erhu Zhao et al.   Cancers

The Role of Sirtuins in Antioxidant and Redox Signaling

(2018) Chandra K. Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

(2018) Surinder Kumar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water

(2018) Xiaoyan Du et al.   ENVIRONMENTAL POLLUTION

Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle

(2018) Alberto Zullo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead-induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways

(2018) Yi Zhang et al.   JOURNAL OF FOOD BIOCHEMISTRY

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

Methylmercury alters proliferation, migration, and antioxidant capacity in human HTR8/SV-neo trophoblast cells

(2018) Emily K. Tucker et al.   REPRODUCTIVE TOXICOLOGY

Role of arsenic exposure in adipose tissue dysfunction and its possible implication in diabetes pathophysiology

(2018) Kaviyarasi Renu et al.   TOXICOLOGY LETTERS

Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

(2018) Alice E. Kane et al.   CIRCULATION RESEARCH

Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells

(2018) Xinyuan Zhao et al.   TOXICOLOGY LETTERS

GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus

(2018) Fei Chen et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

(2018) Yijie Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis

(2018) Xinyuan Zhao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification

(2018) Mohsen Rezaei et al.   TOXICOLOGY LETTERS

Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway

(2018) Giusy Laudati et al.   NEUROTOXICOLOGY

Mitochondrial Biogenesis in Response to Chromium (VI) Toxicity in Human Liver Cells

(2017) Xiali Zhong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

(2017) Xiaoyan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrion: a central architect of copper homeostasis

(2017) Zakery N. Baker et al.   Metallomics

Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations

(2017) Lijie Zhang et al.   Frontiers in Physiology

The Substrate Specificity of Sirtuins

(2016) Poonam Bheda et al.   Annual Review of Biochemistry

Protective Effects of PGC-1α Against Lead-Induced Oxidative Stress and Energy Metabolism Dysfunction in Testis Sertoli Cells

(2016) Xi Liu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans

(2016) Chan-Wei Yu et al.   CHEMOSPHERE

The effect of lead exposure on expression of SIRT1 in the rat hippocampus

(2016) Chang Feng et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Copper toxicology, oxidative stress and inflammation using zebrafish as experimental model

(2016) Talita Carneiro Brandão Pereira et al.   JOURNAL OF APPLIED TOXICOLOGY

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The role of PGC-1α and MRP1 in lead-induced mitochondrial toxicity in testicular Sertoli cells

(2016) Zhen Li et al.   TOXICOLOGY

Sirtuins and nonalcoholic fatty liver disease

(2016) Fatiha Nassir et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity

(2016) Daqian Yang et al.   Scientific Reports

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

(2015) Huifeng Pi et al.   Autophagy

The chemical biology of sirtuins

(2015) Bing Chen et al.   CHEMICAL SOCIETY REVIEWS

Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells

(2015) Iwona Inkielewicz-Stepniak et al.   International Journal of Nanomedicine

Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload

(2015) Subhash K. Das et al.   LIVER INTERNATIONAL

Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway

(2015) Deep Raj Sharma et al.   NEUROTOXICOLOGY

Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway

(2015) Sasidharan Padmaja Divya et al.   TOXICOLOGICAL SCIENCES

NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells

(2015) Wei-Xia Duan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway

(2015) Apichaya Niyomchan et al.   TOXICOLOGY LETTERS

Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy

(2015) Subhash K. Das et al.   Scientific Reports

Changes in the expression of epigenetic factors during copper-induced apoptosis in PC12 cells

(2014) Yongkun Sun et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

Neurobehavioral changes in response to alterations in gene expression profiles in the brains of mice exposed to low and high levels of mercury vapor during postnatal development

(2014) Minoru Yoshida et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake

(2014) Zhenguo Liu et al.   Neural Regeneration Research

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1

(2014) S M Jeong et al.   ONCOGENE

Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures

(2014) Vernat Exil et al.   PLoS One

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro

(2014) Pan Guo et al.   TOXICOLOGICAL SCIENCES

Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes

(2014) Katharine J. Herbert et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabeticdb/dbMice by Inhibition of Hepatic Gluconeogenesis

(2014) Young-Sun Lee et al.   Journal of Diabetes Research

Sirtuin 6: a review of biological effects and potential therapeutic properties

(2013) Jade M. Beauharnois et al.   Molecular BioSystems

Low level methylmercury enhances CNTF-evoked STAT3 signaling and glial differentiation in cultured cortical progenitor cells

(2013) Nathan J. Jebbett et al.   NEUROTOXICOLOGY

Effects of manganese and arsenic species on the level of energy related nucleotides in human cells

(2012) Julia Bornhorst et al.   Metallomics

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Responses of Human Lung Epithelial Cells to the Toxicity of Copper Oxide Nanoparticles Inferred from Whole Genome Expression Analysis

(2011) Nobutaka Hanagata et al.   ACS Nano

Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1

(2009) Lei Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-κB-mediated induction of XIAP, cIAP2, BCL-XL and survivin

(2009) Majid Momeny et al.   MEDICAL ONCOLOGY